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Items: 8

1.

Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma [RNA-seq]

(Submitter supplied) Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer, with no effective treatment available. Identification of new anti-ATC drugs represents an urgent need. In this study, we find that ATC cells are highly sensitive to THZ531, a potent inhibitor of the transcriptional cyclin-dependent kinase (CDK), CDK12. Cell-based assays demonstrate that CDK12 inhibition significantly impedes cell cycle progression, induces apoptotic cell death, and impairs colony formation in ATC cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE137697
ID:
200137697
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

CAL-62_400 nM THZ531 rep2

Organism:
Homo sapiens
Source name:
CAL-62_400 nM THZ531
Platform:
GPL24676
Series:
GSE137697 GSE137698
Download data: TXT
Sample
Accession:
GSM4085085
ID:
304085085
4.

CAL-62_400 nM THZ531 rep1

Organism:
Homo sapiens
Source name:
CAL-62_400 nM THZ531
Platform:
GPL24676
Series:
GSE137697 GSE137698
Download data: TXT
Sample
Accession:
GSM4085084
ID:
304085084
5.

CAL-62_100 nM THZ531 rep2

Organism:
Homo sapiens
Source name:
CAL-62_100 nM THZ531
Platform:
GPL24676
Series:
GSE137697 GSE137698
Download data: TXT
Sample
Accession:
GSM4085083
ID:
304085083
6.

CAL-62_100 nM THZ531 rep1

Organism:
Homo sapiens
Source name:
CAL-62_100 nM THZ531
Platform:
GPL24676
Series:
GSE137697 GSE137698
Download data: TXT
Sample
Accession:
GSM4085082
ID:
304085082
7.

CAL-62_DMSO rep2

Organism:
Homo sapiens
Source name:
CAL-62_DMSO
Platform:
GPL24676
Series:
GSE137697 GSE137698
Download data: TXT
Sample
Accession:
GSM4085081
ID:
304085081
8.

CAL-62_DMSO rep1

Organism:
Homo sapiens
Source name:
CAL-62_DMSO
Platform:
GPL24676
Series:
GSE137697 GSE137698
Download data: TXT
Sample
Accession:
GSM4085080
ID:
304085080
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Supplemental Content

db=gds|term=GSE137697[Accession]|query=1|qty=2|blobid=MCID_6669d2e7ac4a2c105084dba4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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