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Items: 1 to 20 of 78

1.

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

(Submitter supplied) We found in this study through targeted CRISPR-Cas9 screening of RBPs that disrupting YTHDF2-dependent degradation of its target transcripts triggers apoptosis of MYC-dependent cancer cells and tumors. Enhanced CLIP (eCLIP), m6A-sequencing (m6A-seq) and YTHDF2 knockdown followed by RNA-seq analysis of YTHDF2-m6A-mRNA interactions revealed extensive associations with mRNAs encoding MAPK pathway genes that when stabilized, induce epithelial-to-mesenchymal transition and stress-induced apoptosis. more...
Organism:
synthetic construct; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL20301 GPL24676 GPL21616
74 Samples
Download data: BED, BED12, BW, TXT
Series
Accession:
GSE137258
ID:
200137258
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

Illumina HiSeq 4000 (synthetic construct)

Organism:
synthetic construct
35 Series
6714 Samples
Download data
Platform
Accession:
GPL21616
ID:
100021616
4.

Illumina HiSeq 4000 (Homo sapiens)

Platform
Accession:
GPL20301
ID:
100020301
5.

MYC_HMEC_SHY2_rep2 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4795205
ID:
304795205
6.

MYC_HMEC_SHY2_rep1 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4795204
ID:
304795204
7.

MYC_HMEC_SHY1_rep2 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4795203
ID:
304795203
8.

MYC_HMEC_SHY1_rep1 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4795202
ID:
304795202
9.

MYC_HMEC_TAM_SHY1_rep2 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4074039
ID:
304074039
10.

MYC_HMEC_TAM_SHY1_rep1 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4074038
ID:
304074038
11.

MYC_HMEC_TAM_SHY2_rep2 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4074037
ID:
304074037
12.

MYC_HMEC_TAM_SHY2_rep1 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4074036
ID:
304074036
13.

MYC_HMEC_TAM_NTC_rep2 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4074035
ID:
304074035
14.

MYC_HMEC_TAM_NTC_rep1 [RNA-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data
Sample
Accession:
GSM4074034
ID:
304074034
15.

SKBR3_INPUT_rep2 [m6A-seq]

Organism:
Homo sapiens
Source name:
SKBR3
Platform:
GPL20301
Series:
GSE137258
Download data: BW
Sample
Accession:
GSM4074033
ID:
304074033
16.

SKBR3_M6A_rep2 [m6A-seq]

Organism:
Homo sapiens
Source name:
SKBR3
Platform:
GPL20301
Series:
GSE137258
Download data: BW
Sample
Accession:
GSM4074032
ID:
304074032
17.

SKBR3_INPUT_rep1 [m6A-seq]

Organism:
Homo sapiens
Source name:
SKBR3
Platform:
GPL20301
Series:
GSE137258
Download data: BW
Sample
Accession:
GSM4074031
ID:
304074031
18.

SKBR3_M6A_rep1 [m6A-seq]

Organism:
Homo sapiens
Source name:
SKBR3
Platform:
GPL20301
Series:
GSE137258
Download data: BW
Sample
Accession:
GSM4074030
ID:
304074030
19.

MCF7_INPUT_rep2 [m6A-seq]

Organism:
Homo sapiens
Source name:
MCF-7
Platform:
GPL20301
Series:
GSE137258
Download data: BW
Sample
Accession:
GSM4074029
ID:
304074029
20.

MCF7_M6A_rep2 [m6A-seq]

Organism:
Homo sapiens
Source name:
MCF-7
Platform:
GPL20301
Series:
GSE137258
Download data: BW
Sample
Accession:
GSM4074028
ID:
304074028
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Supplemental Content

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