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Items: 1 to 20 of 1477

1.

Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response Against Influenza Virus

(Submitter supplied) Antibodies display antigen-binding loops comprised of a hypervariable CDRH3 and V gene-encoded CDRs, where the latter may harbor gene-endowed or ‘public’ targeting solutions. To test this, we generated transgenic mice containing human CDRH3 diversity but simultaneously constrained to individual human immunoglobulin VH genes, including IGHV1-69, which shows biased usage in human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of Group 1 influenza A viruses. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16417
1475 Samples
Download data: TXT
Series
Accession:
GSE135761
ID:
200135761
2.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
3.

BCR35__S0086_S86

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029131
ID:
304029131
4.

BCR35__S0085_S85

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029130
ID:
304029130
5.

BCR35__S0084_S84

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029129
ID:
304029129
6.

BCR35__S0083_S83

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029128
ID:
304029128
7.

BCR35__S0081_S81

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029127
ID:
304029127
8.

BCR35__S0077_S77

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029126
ID:
304029126
9.

BCR35__S0075_S75

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029125
ID:
304029125
10.

BCR35__S0072_S72

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029124
ID:
304029124
11.

BCR35__S0071_S71

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029123
ID:
304029123
12.

BCR35__S0070_S70

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029122
ID:
304029122
13.

BCR35__S0069_S69

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029121
ID:
304029121
14.

BCR35__S0065_S65

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029120
ID:
304029120
15.

BCR35__S0064_S64

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029119
ID:
304029119
16.

BCR35__S0062_S62

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029118
ID:
304029118
17.

BCR35__S0061_S61

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029117
ID:
304029117
18.

BCR35__S0057_S57

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029116
ID:
304029116
19.

BCR35__S0050_S50

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029115
ID:
304029115
20.

BCR35__S0049_S49

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Adoptive Transfer_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4029114
ID:
304029114
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