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Items: 1 to 20 of 136

1.

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

(Submitter supplied) Adaptation of the islet β-cell insulin secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we show that nutrient cues adapt insulin secretion by modulating chromatin state and transcription of genes regulating β-cell nutrient sensing and metabolism. Feeding stimulates histone acetylation at sites occupied by the chromatin-modifying enzyme Lsd1 in islets. more...
Organism:
Homo sapiens; Mus; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
131 Samples
Download data: BEDGRAPH, DIFF, TXT
Series
Accession:
GSE134901
ID:
200134901
2.

Illumina NovaSeq 6000 (Mus)

Platform
Accession:
GPL31136
ID:
100031136
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

Illumina HiSeq 4000 (Mus musculus)

Platform
Accession:
GPL21103
ID:
100021103
5.

Illumina HiSeq 4000 (Homo sapiens)

Platform
Accession:
GPL20301
ID:
100020301
6.

mm_islets_LsdKIWk3_H3K27ac_ChIPseq_3

Organism:
Mus
Source name:
Pancreatic islets
Platform:
GPL31136
Series:
GSE134901
Download data
Sample
Accession:
GSM6407349
ID:
306407349
7.

mm_islets_LsdKIWk3_H3K27ac_ChIPseq_2

Organism:
Mus
Source name:
Pancreatic islets
Platform:
GPL31136
Series:
GSE134901
Download data
Sample
Accession:
GSM6407348
ID:
306407348
8.

mm_islets_LsdKIWk3_H3K27ac_ChIPseq_1

Organism:
Mus
Source name:
Pancreatic islets
Platform:
GPL31136
Series:
GSE134901
Download data
Sample
Accession:
GSM6407347
ID:
306407347
9.

mm_islets_CtrlforLsdKI_H3K27ac_ChIPseq_2

Organism:
Mus
Source name:
Pancreatic islets
Platform:
GPL31136
Series:
GSE134901
Download data
Sample
Accession:
GSM6407346
ID:
306407346
10.

mm_islets_CtrlforLsdKI_H3K27ac_ChIPseq_1

Organism:
Mus
Source name:
Pancreatic islets
Platform:
GPL31136
Series:
GSE134901
Download data
Sample
Accession:
GSM6407345
ID:
306407345
11.

mm_islets_dbdb_H3K4me1_ChIPseq_C

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978653
ID:
303978653
12.

mm_islets_dbdb_H3K4me1_ChIPseq_A

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978652
ID:
303978652
13.

mm_islets_dbhet_H3K4me1_ChIPseq_E

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978651
ID:
303978651
14.

mm_islets_dbhet_H3K4me1_ChIPseq_B

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978650
ID:
303978650
15.

mm_islets_dbdb_input_ChIPseq_C

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978649
ID:
303978649
16.

mm_islets_dbdb_input_ChIPseq_A

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978648
ID:
303978648
17.

mm_islets_dbhet_input_ChIPseq_E

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978647
ID:
303978647
18.

mm_islets_dbhet_input_ChIPseq_B

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978646
ID:
303978646
19.

mm_islets_dbdb_H3K27Ac_ChIPseq_B

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978645
ID:
303978645
20.

mm_islets_dbdb_H3K27Ac_ChIPseq_A

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978644
ID:
303978644
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