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Items: 1 to 20 of 35

1.

Mutant Kras co-opts a progenitor-derived enhancer network to initiate pancreatic tumorigenesis [ChIP-seq]

(Submitter supplied) Oncogenes are highly specific in the cells they can transform, although the molecular basis for this is poorly understood. Inflammation often promotes tumorigenesis, and in the pancreas it promotes cellular plasticity and accelerates Kras-driven neoplasia. We demonstrate that plasticity is coupled to the emergence of transient progenitor cells that are readily transformed by KrasG12D. The progenitor state is linked to coordinate upregulation of proliferation genes through chromatin opening at nearby lineage-specific enhancers. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21273
33 Samples
Download data: BW
Series
Accession:
GSE134233
ID:
200134233
2.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
3.

Foxa2-OE_Junb_and_Fosl1+KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443874
ID:
304443874
4.

Foxa2-OE_Junb_and_Fosl1-KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443873
ID:
304443873
5.

Foxa2-OE_Vector+KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443872
ID:
304443872
6.

Foxa2-OE_Vector-KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443871
ID:
304443871
7.

Klf5-OE_Junb_and_Fosl1+KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443870
ID:
304443870
8.

Klf5-OE_Junb_and_Fosl1-KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443869
ID:
304443869
9.

Klf5-OE_Vector+KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443868
ID:
304443868
10.

Klf5-OE_Vector-KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443867
ID:
304443867
11.

Input_KP_H3K27ac+KrasG12D_ChIP_MK-2206 2HCl_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data
Sample
Accession:
GSM4443866
ID:
304443866
12.

KP_H3K27ac+KrasG12D_ChIP_DMSO_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443865
ID:
304443865
13.

KP_H3K27ac+KrasG12D_ChIP_MK-2206 2HCl_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443864
ID:
304443864
14.

KP_H3K27ac+KrasG12D_ChIP_Refametinib_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443863
ID:
304443863
15.

KP_H3K27ac+KrasG12D_ChIP_PD0325901_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443862
ID:
304443862
16.

KPCS_H3K27ac+KrasG12D_ChIP_DMSO_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443861
ID:
304443861
17.

KPCS_H3K27ac+KrasG12D_ChIP_MK-2206 2HCl_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443860
ID:
304443860
18.

KPCS_H3K27ac+KrasG12D_ChIP_Refametinib_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443859
ID:
304443859
19.

KPCS_H3K27ac+KrasG12D_ChIP_PD0325901_treatment

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM4443858
ID:
304443858
20.

Klf5+KrasG12D_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM3940115
ID:
303940115
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