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Items: 1 to 20 of 36

1.

Hi-C to Identify Interactions between Distant Genomic Loci due to BRD4-NUT-mediated Megadomain Formation

(Submitter supplied) Delineating how chromosomes fold at length scales beyond one megabase remains obscure relative to smaller-scale folding into TADs, loops, and nucleosomes. We find that rather than simply unfolding chromatin, histone hyperacetylation results in interactions between distant genomic loci separated by tens to hundreds of megabases, even in the absence of transcription. These hyperacetylated “megadomains” are formed by the BRD4-NUT fusion oncoprotein, interact both within and between chromosomes, and form a specific nuclear subcompartment that has elevated gene activity with respect to other subcompartments. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL24676 GPL20795 GPL15520
32 Samples
Download data: BED, BEDPE, BW, HIC
Series
Accession:
GSE133163
ID:
200133163
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

HiSeq X Ten (Homo sapiens)

Platform
Accession:
GPL20795
ID:
100020795
4.

Illumina MiSeq (Homo sapiens)

Platform
Accession:
GPL15520
ID:
100015520
5.

TC-797_washout_replicate1 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL20795
Series:
GSE133163 GSE133165
Download data: HIC
Sample
Accession:
GSM3901277
ID:
303901277
6.

TC-797_MZ1_replicate1 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL20795
Series:
GSE133163 GSE133165
Download data: HIC
Sample
Accession:
GSM3901275
ID:
303901275
7.

TC-797_DMSO_replicate1 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL20795
Series:
GSE133163 GSE133165
Download data: HIC
Sample
Accession:
GSM3901273
ID:
303901273
8.

293TRex_induced_replicate2 (HiC)

Organism:
Homo sapiens
Source name:
293TRex-Flag-BRD4-NUT-HA cultured cells
Platform:
GPL20795
Series:
GSE133163 GSE133165
Download data: HIC
Sample
Accession:
GSM3901272
ID:
303901272
9.

293TRex_induced_replicate1 (HiC)

Organism:
Homo sapiens
Source name:
293TRex-Flag-BRD4-NUT-HA cultured cells
Platform:
GPL20795
Series:
GSE133163 GSE133165
Download data: HIC
Sample
Accession:
GSM3901271
ID:
303901271
10.

293TRex_uninduced_replicate2 (HiC)

Organism:
Homo sapiens
Source name:
293TRex-Flag-BRD4-NUT-HA cultured cells
Platform:
GPL20795
Series:
GSE133163 GSE133165
Download data: HIC
Sample
Accession:
GSM3901270
ID:
303901270
11.

293TRex_uninduced_replicate1 (HiC)

Organism:
Homo sapiens
Source name:
293TRex-Flag-BRD4-NUT-HA cultured cells
Platform:
GPL20795
Series:
GSE133163 GSE133165
Download data: HIC
Sample
Accession:
GSM3901269
ID:
303901269
12.

TC-797_Triptolide_input_replicate2 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM4134935
ID:
304134935
13.

TC-797_Triptolide_input_replicate1 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM4134934
ID:
304134934
14.

TC-797_input_replicate6 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM4134933
ID:
304134933
15.

TC-797_input_replicate5 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM4134932
ID:
304134932
16.

TC-797_input_replicate4 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM4134931
ID:
304134931
17.

TC-797_input_replicate3 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM4134930
ID:
304134930
18.

TC-797_washout_input_replicate2 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM3901288
ID:
303901288
19.

TC-797_washout_input_replicate1 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM3901287
ID:
303901287
20.

TC-797_MZ1_input_replicate2 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM3901286
ID:
303901286
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