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Items: 6

1.

Senescence rather than apoptosis of alveolar progenitor cells drives pulmonary fibrosis (mouse scRNAseq)

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a fatal form of interstitial lung disease associated with progressive scarring of lung tissue and declining pulmonary function in aging individuals. Here we employ data mining and single cell RNA sequencing (scRNAseq) to define candidate drivers of AT2 senescence in IPF lung tissue. We show that AT2 cells isolated from IPF lung tissue exhibit characteristic features of cellular senescence and reduced abundance of Sin3a, critical determinant of endodermal progenitor cell maintenance in the developing lung. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: H5
Series
Accession:
GSE132910
ID:
200132910
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

Epithelial cells, Sin3a-LOF_6wk

Organism:
Mus musculus
Source name:
mouse lung
Platform:
GPL24247
Series:
GSE132910 GSE132915
Download data: H5
Sample
Accession:
GSM3896272
ID:
303896272
4.

Epithelial cells, Sin3a-LOF_4wk

Organism:
Mus musculus
Source name:
mouse lung
Platform:
GPL24247
Series:
GSE132910 GSE132915
Download data: H5
Sample
Accession:
GSM3896271
ID:
303896271
5.

Epithelial cells, control_6wk

Organism:
Mus musculus
Source name:
mouse lung
Platform:
GPL24247
Series:
GSE132910 GSE132915
Download data: H5
Sample
Accession:
GSM3896270
ID:
303896270
6.

Epithelial cells, control_4wk

Organism:
Mus musculus
Source name:
mouse lung
Platform:
GPL24247
Series:
GSE132910 GSE132915
Download data: H5
Sample
Accession:
GSM3896269
ID:
303896269
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Supplemental Content

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