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Items: 11

1.

Downregulation of Uhrf1 activity by TGF-β signaling controls Foxp3 methylation and iTreg cell differentiation

(Submitter supplied) Foxp3+ regulatory T cells (Treg cells) are essential for immune system homeostasis and suppression of excessive immune responses. Both TGF-β signaling and epigenetic modifications are important in the regulation of Foxp3 induction, but whether TGF-β signaling participates in the epigenetic regulation of Foxp3 has not been fully clarified. Here, we show that Uhrf1, which is induced by TCR stimulation and regulated by TGF-β signaling, controls Foxp3 methylation and iTreg cell differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL21273 GPL24247
8 Samples
Download data: TXT
Series
Accession:
GSE128480
ID:
200128480
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
4.

RNA Seq-KO T cells-3

Organism:
Mus musculus
Source name:
lymph nodes
Platform:
GPL24247
Series:
GSE128480
Download data
Sample
Accession:
GSM3962938
ID:
303962938
5.

RNA Seq-KO T cells-2

Organism:
Mus musculus
Source name:
lymph nodes
Platform:
GPL24247
Series:
GSE128480
Download data
Sample
Accession:
GSM3962937
ID:
303962937
6.

RNA Seq-WT T cells-3

Organism:
Mus musculus
Source name:
lymph nodes
Platform:
GPL24247
Series:
GSE128480
Download data
Sample
Accession:
GSM3962936
ID:
303962936
7.

RNA Seq-WT T cells-2

Organism:
Mus musculus
Source name:
lymph nodes
Platform:
GPL24247
Series:
GSE128480
Download data
Sample
Accession:
GSM3962935
ID:
303962935
8.

RNA Seq-KO T cells

Organism:
Mus musculus
Source name:
CD4+ T cells
Platform:
GPL24247
Series:
GSE128480
Download data
Sample
Accession:
GSM3676895
ID:
303676895
9.

RNA Seq-WT T cells

Organism:
Mus musculus
Source name:
CD4+ T cells
Platform:
GPL24247
Series:
GSE128480
Download data
Sample
Accession:
GSM3676894
ID:
303676894
10.

WGBS-KO T cells

Organism:
Mus musculus
Source name:
CD4+ T cells
Platform:
GPL21273
Series:
GSE128480
Download data: TXT
Sample
Accession:
GSM3684263
ID:
303684263
11.

WGBS-WT T cells

Organism:
Mus musculus
Source name:
CD4+ T cells
Platform:
GPL21273
Series:
GSE128480
Download data: TXT
Sample
Accession:
GSM3684262
ID:
303684262
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Supplemental Content

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