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Items: 7

1.

Point mutations in the PDX1 transactivation domain impair human β-cell development and function (ChIP-Seq)

(Submitter supplied) Missense mutations in coding region of PDX1 predispose to type-2 diabetes mellitus as well as cause MODY through largely unexplored mechanisms. Here, we screened a large cohort of subjects with increased risk for diabetes and identified two subjects with impaired glucose tolerance carrying heterozygous missense mutations in the PDX1 coding region leading to single amino acid exchanges (P33T, C18R) in its transactivation domain. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18460
5 Samples
Download data: BED
Series
Accession:
GSE125768
ID:
200125768
2.

Illumina HiSeq 1500 (Homo sapiens)

Platform
Accession:
GPL18460
ID:
100018460
3.

P33T-PP_PDX1_Lane2_CTTGTA

Organism:
Homo sapiens
Source name:
PDX1P33T/+ iPS derived pancreatic precursor cells
Platform:
GPL18460
Series:
GSE125768 GSE125770
Download data
Sample
Accession:
GSM3581648
ID:
303581648
4.

P33T-PP_PDX1_Lane1_CTTGTA

Organism:
Homo sapiens
Source name:
PDX1P33T/+ iPS derived pancreatic precursor cells
Platform:
GPL18460
Series:
GSE125768 GSE125770
Download data
Sample
Accession:
GSM3581647
ID:
303581647
5.

P33T-PP_H3K27ac_Lane3_TAGCTT

Organism:
Homo sapiens
Source name:
PDX1P33T/+ iPS derived pancreatic precursor cells
Platform:
GPL18460
Series:
GSE125768 GSE125770
Download data
Sample
Accession:
GSM3581646
ID:
303581646
6.

P33T-PP_H3K27ac_Lane2_TAGCTT

Organism:
Homo sapiens
Source name:
PDX1P33T/+ iPS derived pancreatic precursor cells
Platform:
GPL18460
Series:
GSE125768 GSE125770
Download data
Sample
Accession:
GSM3581645
ID:
303581645
7.

P33T-PP_H3K27ac_Lane1_TAGCTT

Organism:
Homo sapiens
Source name:
PDX1P33T/+ iPS derived pancreatic precursor cells
Platform:
GPL18460
Series:
GSE125768 GSE125770
Download data
Sample
Accession:
GSM3581644
ID:
303581644
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Supplemental Content

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