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Items: 11

1.

Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis

(Submitter supplied) CBX4, a component of polycomb repressive complex 1 (PRC1), plays important roles in the maintenance of cell identity and organ development through epigenetic silencing. However, whether CBX4 regulates the homeostasis of human stem cells remains unclear. Here, we demonstrate that CBX4 counteracts human mesenchymal stem cell (hMSC) aging via the maintenance of nucleolar homeostasis. CBX4 protein is decreased in aged hMSCs, and targeted CBX4 knockout in young hMSCs results in destabilized nucleolar heterochromatin, increased ribosome biogenesis and protein translation, and accelerated cellular senescence. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
9 Samples
Download data: TSV
Series
Accession:
GSE125320
ID:
200125320

SRA Run Selector

2.

HiSeq X Ten (Mus musculus)

Organism:
Mus musculus
1865 Series
40491 Samples
Download data
Platform
Accession:
GPL21273
ID:
100021273

3.

OA model_Lentiviruses expressing CBX4 rep3

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568923
ID:
303568923

SRA Run Selector

4.

OA model_Lentiviruses expressing CBX4 rep2

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568922
ID:
303568922

SRA Run Selector

5.

OA model_Lentiviruses expressing CBX4 rep1

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568921
ID:
303568921

SRA Run Selector

6.

OA model_Lentiviruses expressing Luc rep3

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568920
ID:
303568920

SRA Run Selector

7.

OA model_Lentiviruses expressing Luc rep2

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568919
ID:
303568919

SRA Run Selector

8.

OA model_Lentiviruses expressing Luc rep1

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568918
ID:
303568918

SRA Run Selector

9.

OA model_Non surgery rep3

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568917
ID:
303568917

SRA Run Selector

10.

OA model_Non surgery rep2

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568916
ID:
303568916

SRA Run Selector

11.

OA model_Non surgery rep1

Organism:
Mus musculus
Source name:
knee joints
Platform:
GPL21273
Series:
GSE125320
Download data: TSV
Sample
Accession:
GSM3568915
ID:
303568915

SRA Run Selector

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db=gds|term=GSE125320[Accession]|query=1|qty=2|blobid=MCID_67899480f5211606909eb2c6|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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