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Items: 8

1.

A recurrently amplified long noncoding RNA in colorectal cancer regulates p53 protein stability through GRWD1/RPL11/MDM2 axis [RNA-seq]

(Submitter supplied) By integrating genome-wide copy number alteration, RNA-seq and proteomics data from 589 colorectal cancer (CRC) patients, we revealed that chromosome 8q24.21 amplification is negatively correlated with p53 protein stability. Using siRNA and CRISPR activation screening, we pinpointed a novel long noncoding gene (PiHL, P53 inHibiting LncRNA) from 8q24.21 as a p53 negative regulator. PiHL is drastically upregulated in CRC and is an independent predictor of CRC poor prognosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
6 Samples
Download data: XLS
2.

Illumina HiSeq 3000 (Homo sapiens)

Platform
Accession:
GPL21290
ID:
100021290
3.

siRNA-PiHL_rep3

Organism:
Homo sapiens
Source name:
Colon cancer
Platform:
GPL21290
Series:
GSE124526
Download data
Sample
Accession:
GSM3535854
ID:
303535854
4.

siRNA-PiHL_rep2

Organism:
Homo sapiens
Source name:
Colon cancer
Platform:
GPL21290
Series:
GSE124526
Download data
Sample
Accession:
GSM3535853
ID:
303535853
5.

siRNA-PiHL_rep1

Organism:
Homo sapiens
Source name:
Colon cancer
Platform:
GPL21290
Series:
GSE124526
Download data
Sample
Accession:
GSM3535852
ID:
303535852
6.

siRNA-NC_rep3

Organism:
Homo sapiens
Source name:
Colon cancer
Platform:
GPL21290
Series:
GSE124526
Download data
Sample
Accession:
GSM3535851
ID:
303535851
7.

siRNA-NC_rep2

Organism:
Homo sapiens
Source name:
Colon cancer
Platform:
GPL21290
Series:
GSE124526
Download data
Sample
Accession:
GSM3535850
ID:
303535850
8.

siRNA-NC_rep1

Organism:
Homo sapiens
Source name:
Colon cancer
Platform:
GPL21290
Series:
GSE124526
Download data
Sample
Accession:
GSM3535849
ID:
303535849
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Supplemental Content

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