GEO DataSets

(Submitter supplied) The majority of breast tumours express oestrogen receptor (ER) and receive endocrine therapy (ET) as standard care. Despite its efficacy, ~40% of women relapse with endocrine therapy-resistant (ETR) disease. A global transcription analysis and subsequent integrative approaches of ETR cells showed a deregulated node between miR-23b-3p and the amino acids transporter SLC6A14. Mechanistic analysis supports a model in which such deregulation impairs amino acids metabolism in the ETR cells with subsequent activation of autophagy and enhanced aspartate and glutamate import mediated by the SLC1A2 transporter. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14550

9 Samples

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(Submitter supplied) SurePrint G3 Human GE 8x60K Microarray *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL13607. Protocol: see manufacturer's web site at http://www.agilent.com/

Organism:

Homo sapiens

382 Series

1 Related Platform

8114 Samples

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