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Items: 6

1.

Acc1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis [RNA-seq]

(Submitter supplied) Immunological memory is central to adaptive immunity and protection from disease. Changing metabolic demands as antigen-specific T cells transition from effector to memory have been well documented, but the cell-specific pathways and molecules that govern this transition are poorly defined. ACC1 is a rate-limiting enzym in fatty acid biosynthesis. We show that genetic deletion of ACC1 enhanced the formation of CD4+ T cell memory, and that inhibition of ACC1 function enhanced memory T cell formation during parasite infection in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
4 Samples
Download data: TXT
Series
Accession:
GSE120667
ID:
200120667
2.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
3.

CCR7loCD137hi-2_ RNA

Organism:
Mus musculus
Source name:
Sorted subpopulation (CCR7loCD137hi) of five-day cultured Th1 cells.
Platform:
GPL18480
Series:
GSE120667 GSE122863
Download data: TXT
Sample
Accession:
GSM3408032
ID:
303408032
4.

CCR7hiCD137lo-2_ RNA

Organism:
Mus musculus
Source name:
Sorted subpopulation (CCR7hiCD137lo) of five-day cultured Th1 cells.
Platform:
GPL18480
Series:
GSE120667 GSE122863
Download data: TXT
Sample
Accession:
GSM3408031
ID:
303408031
5.

CCR7loCD137hi-1_ RNA

Organism:
Mus musculus
Source name:
Sorted subpopulation (CCR7loCD137hi) of five-day cultured Th1 cells.
Platform:
GPL18480
Series:
GSE120667 GSE122863
Download data: TXT
Sample
Accession:
GSM3408030
ID:
303408030
6.

CCR7hiCD137lo-1_ RNA

Organism:
Mus musculus
Source name:
Sorted subpopulation (CCR7hiCD137lo) of five-day cultured Th1 cells.
Platform:
GPL18480
Series:
GSE120667 GSE122863
Download data: TXT
Sample
Accession:
GSM3408029
ID:
303408029
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Supplemental Content

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