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Items: 10

1.

Inhibition of O-GlcNAc transferase renders prostate cancer cells dependent on CDK9

(Submitter supplied) O-GlcNAc transferase (OGT) is a nutrient-sensitive glycosyltransferase that is overexpressed in prostate cancer, the most common cancer in males. We recently developed specific and potent inhibitor targeting this enzyme, and here we report a synthetic lethality screen using this compound. Our screen identified pan-cyclin-dependent kinase (CDK) inhibitor AT7519 as lethal in combination with OGT inhibition. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
8 Samples
Download data: TXT
2.

Illumina HiSeq 3000 (Homo sapiens)

Platform
Accession:
GPL21290
ID:
100021290
3.

LnCaP_Combination_Replicate2

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261828
ID:
303261828
4.

LnCaP_Combination_Replicate1

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261827
ID:
303261827
5.

LnCaP_AT7519_Replicate2

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261826
ID:
303261826
6.

LnCaP_AT7519_Replicate1

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261825
ID:
303261825
7.

LnCaP_OSMI2_Replicate2

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261824
ID:
303261824
8.

LnCaP_OSMI2_Replicate1

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261823
ID:
303261823
9.

LnCaP_Control_Replicate2

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261822
ID:
303261822
10.

LnCaP_Control_Replicate1

Organism:
Homo sapiens
Source name:
LnCaP Cell Line
Platform:
GPL21290
Series:
GSE116778
Download data
Sample
Accession:
GSM3261821
ID:
303261821
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Supplemental Content

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