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Items: 13

1.

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development [Bisulfite-seq]

(Submitter supplied) The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis. Yet, how it is established remains elusive. Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. Deficiency in Setd2 leads to extensive alterations of the oocyte epigenome, including the loss of H3K36me3, failure in establishing the correct DNA methylome, invasion of H3K4me3 and H3K27me3 into former H3K36me3 territories and aberrant acquisition of H3K4me3 at imprinting control regions instead of DNA methylation. more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL21273
11 Samples
Download data
Series
Accession:
GSE112833
ID:
200112833
2.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
3.

MethylC_FGO_Setd2_KO_5mC_rep2

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3494197
ID:
303494197
4.

MethylC_GO_P7_Setd2_KO_5mC_rep2

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3494196
ID:
303494196
5.

MethylC_GO_P7_Setd2_KO_5mC_rep1

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3494195
ID:
303494195
6.

MethylC_GO_P7_Setd2_Con_5mC

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3494194
ID:
303494194
7.

MethylC_FGO_Setd2_KO_5mC_rep1

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3084614
ID:
303084614
8.

MethylC_FGO_Setd2_Con_5mC_rep2

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3084613
ID:
303084613
9.

MethylC_FGO_Setd2_Con_5mC_rep1

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3084612
ID:
303084612
10.

MethylC_FGO_Dnmt3l_KO_5mC_rep2

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3084611
ID:
303084611
11.

MethylC_FGO_Dnmt3l_KO_5mC_rep1

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3084610
ID:
303084610
12.

MethylC_FGO_Dnmt3l_Con_5mC_rep2

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3084609
ID:
303084609
13.

MethylC_FGO_Dnmt3l_Con_5mC_rep1

Organism:
Mus musculus
Source name:
oocyte
Platform:
GPL21273
Series:
GSE112833 GSE112835
Download data
Sample
Accession:
GSM3084608
ID:
303084608
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Supplemental Content

db=gds|term=GSE112833[Accession]|query=1|qty=2|blobid=MCID_6649f5e23844a3792a4f716a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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