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Items: 15

1.

Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen

(Submitter supplied) Acetaminophen (APAP) is a commonly used analgesic responsible for more than half of acute liver failure cases. Identification of previously unknown genetic risk factors would provide mechanistic insights and novel therapeutic targets for APAP-induced liver injury. This study used a genome-wide CRISPR-Cas9 screen to evaluate genes that are protective against, or cause susceptibility to, APAP-induced liver injury. more...
Organism:
Escherichia coli; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL20045 GPL18460
12 Samples
Download data: TXT
Series
Accession:
GSE112463
ID:
200112463
2.

Illumina HiSeq 1500 (Escherichia coli)

Organism:
Escherichia coli
3 Series
87 Samples
Download data
Platform
Accession:
GPL20045
ID:
100020045
3.

Illumina HiSeq 1500 (Homo sapiens)

Platform
Accession:
GPL18460
ID:
100018460
4.

Plasmid_rep2

Organism:
Escherichia coli
Source name:
GeCKOv2 plasmid library
Platform:
GPL20045
Series:
GSE112463
Download data
Sample
Accession:
GSM3070502
ID:
303070502
5.

Plasmid_rep1

Organism:
Escherichia coli
Source name:
GeCKOv2 plasmid library
Platform:
GPL20045
Series:
GSE112463
Download data
Sample
Accession:
GSM3070501
ID:
303070501
6.

T4d_rep2

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070512
ID:
303070512
7.

T4d_rep1

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070511
ID:
303070511
8.

T24h_rep2

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070510
ID:
303070510
9.

T24h_rep1

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070509
ID:
303070509
10.

T12h

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070508
ID:
303070508
11.

T6h

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070507
ID:
303070507
12.

T3h

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070506
ID:
303070506
13.

T30min

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070505
ID:
303070505
14.

T0_rep2

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070504
ID:
303070504
15.

T0_rep1

Organism:
Homo sapiens
Source name:
HuH7 human hepatocarcinoma cell line
Platform:
GPL18460
Series:
GSE112463
Download data
Sample
Accession:
GSM3070503
ID:
303070503
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Supplemental Content

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