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Items: 13

1.

Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

(Submitter supplied) Obesity, a prevalent condition in adults and children, impairs bone marrow (BM) function. However, the underlying mechanisms are unclear. Here we show that obese mice exhibit poor emergency immune responses in a toll-like receptor 4 (TLR4)-dependent manner. Canonical myeloid genes (Csf1r, Spi1, Runx1) are enhanced, and lymphoid genes (Flt3, Tcf3, Ebf1) are reduced. Using adoptive transfer and mixed BM chimera approaches we demonstrate that myeloid>lymphoid bias arises after six weeks of high fat diet and depends on precursor cell-autonomous TLR4. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
Platform:
GPL24518
11 Samples
Download data: RCC, XLSX
Series
Accession:
GSE109269
ID:
200109269

Analyze with GEO2R

2.

NanoString nCounter custom lympho-myeloid gene set (150)

(Submitter supplied) See manufacturer's website http://www.nanostring.com
Organism:
Homo sapiens
1 Series
11 Samples
Download data
Platform
Accession:
GPL24518
ID:
100024518

3.

HFD 2 LKSneg

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936331
ID:
302936331

4.

HFD 1 LKSneg

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936330
ID:
302936330

5.

NCD 3 LKSneg

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936329
ID:
302936329

6.

NCD 2 LKSneg

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936328
ID:
302936328

7.

NCD 1 LKSneg

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936327
ID:
302936327

8.

HFD 3 CLP

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936326
ID:
302936326

9.

HFD 2 CLP

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936325
ID:
302936325

10.

HFD 1 CLP

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936324
ID:
302936324

11.

NCD 3 CLP

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936323
ID:
302936323

12.

NCD 2 CLP

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936322
ID:
302936322

13.

NCD 1 CLP

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24518
Series:
GSE109269
Download data: RCC
Sample
Accession:
GSM2936321
ID:
302936321

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