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Items: 3

1.

Genetic dissection of the α-globin super-enhancer in vivo [RNA-seq]

(Submitter supplied) Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enhancers. These super-enhancers have been proposed to manifest higher-order properties important in development and disease. Here we report a comprehensive functional dissection of one of the strongest putative super-enhancers in erythroid cells. By generating a series of mouse models, deleting each of the five regulatory elements of the α-globin super-enhancer individually and in informative combinations, we demonstrate that each constituent enhancer seems to act independently and in an additive fashion with respect to hematological phenotype, gene expression, chromatin structure and chromosome conformation, without clear evidence of synergistic or higher-order effects. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
1 Sample
Download data: BW
Series
Accession:
GSE108457
ID:
200108457
2.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
3.

Mouse wild type erythroid cells replicate 1

Organism:
Mus musculus
Source name:
Erythroid cells
Platform:
GPL13112
Series:
GSE108457
Download data: BW
Sample
Accession:
GSM2898780
ID:
302898780
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Supplemental Content

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