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Items: 7

1.

Neonatal imprinting of mesenteric lymph node stroma modulates tolerogenic properties of dendritic cells [scRNA-seq]

(Submitter supplied) Gut-draining mesenteric lymph nodes (mLNs) play a key role in peripheral tolerance towards food and commensal antigens by providing an optimal microenvironment for efficient de novo induction of Foxp3+ regulatory T cells (Tregs). We recently identified mLN stromal cells as critical cellular players in this process and demonstrated that their tolerogenic properties are imprinted by microbiota. Here, we show that this imprinting process already takes place in the neonatal phase and renders the mLN stromal cell compartment resistant to inflammatory perturbations later in life. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL24247
4 Samples
Download data: CSV, H5, TXT
Series
Accession:
GSE106489
ID:
200106489
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

L1700567

Organism:
Mus musculus
Source name:
mLN-SPF
Platform:
GPL19057
Series:
GSE106489 GSE116633
Download data: CSV, H5
Sample
Accession:
GSM2838917
ID:
302838917
5.

L1700566

Organism:
Mus musculus
Source name:
pLN-SPF
Platform:
GPL19057
Series:
GSE106489 GSE116633
Download data: CSV, H5
Sample
Accession:
GSM2838916
ID:
302838916
6.

B6

Organism:
Mus musculus
Source name:
mLN-SPF
Platform:
GPL24247
Series:
GSE106489 GSE116633
Download data: CSV, H5
Sample
Accession:
GSM3162137
ID:
303162137
7.

B5

Organism:
Mus musculus
Source name:
pLN-SPF
Platform:
GPL24247
Series:
GSE106489 GSE116633
Download data: CSV, H5
Sample
Accession:
GSM3162136
ID:
303162136
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Supplemental Content

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