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Items: 9

1.

Ultraconserved Enhancers Are Required for Normal Development [Drop-seq]

(Submitter supplied) Non-coding ultraconserved regions showing hundreds of consecutive bases of perfect evolutionary sequence conservation across mammalian genomes have intrigued biologists in the decade since they were first described. While many of these sequences are known to represent distant-acting enhancers, initial deletion studies in mice showed that their loss had no obvious impact on viability or fertility. To explore the discrepancy between extraordinary evolutionary constraint and an apparent lack of phenotypes when deleted in vivo, we used genome editing to create an expanded series of knockout mice lacking individual or combinations of ultraconserved brain enhancers near the essential neuronal transcription factor Arx. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL22245
6 Samples
Download data: TXT
Series
Accession:
GSE100384
ID:
200100384
2.

Illumina HiSeq 2500 (Homo sapiens; Mus musculus)

Organism:
Homo sapiens; Mus musculus
48 Series
2132 Samples
Download data
Platform
Accession:
GPL22245
ID:
100022245
3.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
4.

hs122-GFP (1)

Organism:
Mus musculus; Homo sapiens
Source name:
embryonic forebrain and 293T/17 cells
Platform:
GPL22245
Series:
GSE100384 GSE100394
Download data
Sample
Accession:
GSM2679969
ID:
302679969
5.

hs122-GFP (2)

Organism:
Homo sapiens; Mus musculus
Source name:
embryonic forebrain and 293T/17 cells
Platform:
GPL22245
Series:
GSE100384 GSE100394
Download data
Sample
Accession:
GSM2679968
ID:
302679968
6.

hs123-mCherry

Organism:
Mus musculus; Homo sapiens
Source name:
embryonic forebrain and 293T/17 cells
Platform:
GPL22245
Series:
GSE100384 GSE100394
Download data
Sample
Accession:
GSM2679967
ID:
302679967
7.

hs121-mCherry

Organism:
Homo sapiens; Mus musculus
Source name:
embryonic forebrain and 293T/17 cells
Platform:
GPL22245
Series:
GSE100384 GSE100394
Download data
Sample
Accession:
GSM2679966
ID:
302679966
8.

hs119-GFP

Organism:
Homo sapiens; Mus musculus
Source name:
embryonic forebrain and 293T/17 cells
Platform:
GPL22245
Series:
GSE100384 GSE100394
Download data
Sample
Accession:
GSM2679965
ID:
302679965
9.

hs122-GFP Bulk Control

Organism:
Mus musculus
Source name:
embryonic forebrain
Platform:
GPL17021
Series:
GSE100384 GSE100394
Download data
Sample
Accession:
GSM2825929
ID:
302825929
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Supplemental Content

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