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Items: 1 to 20 of 11332

1.

Glucocorticoid and Mineralocorticoid Receptor Signaling have Sex-dependent and Independent Effects in Mouse Hippocampus

(Submitter supplied) Many stress-related neuropsychiatric disorders display pronounced sex differences in their frequency and clinical symptoms. Glucocorticoids are primary stress hormones that have been implicated in the development of these disorders but whether they contribute to the observed sex bias is poorly understood. Glucocorticoids signal through two closely related nuclear receptors, the glucocorticoid (GR) and mineralocorticoid receptor (MR), that are both expressed at high levels in the hippocampus. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
31 Samples
Download data: TXT
Series
Accession:
GSE240873
ID:
200240873
2.

Glucocorticoid receptor signaling in adipose tissue

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
32 Samples
Download data: TXT
Series
Accession:
GSE241653
ID:
200241653
3.

Glucocorticoid receptor signaling in adipose tissue II

(Submitter supplied) Comparison of differences in gene expression in white and brown adipose tissues in the presence and absence of glucocorticoid receptor expression.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
16 Samples
Download data: TXT
Series
Accession:
GSE241652
ID:
200241652
4.

Glucocorticoid receptor signaling in adipose tissue I

(Submitter supplied) Comparison of differences in gene expression in white and brown adipose tissues in the presence and absence of glucocorticoid receptor expression.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
16 Samples
Download data: TXT
Series
Accession:
GSE241651
ID:
200241651
5.

Differential gene expression in Gaddβ KO mice treated with diethylnitrosamine and phenobarbital

(Submitter supplied) To find Gadd45β dependent gene regulation in mouse hepatocellular carcinoma induced by diethylnitorsamine + phenobarbital
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
16 Samples
Download data: TXT
Series
Accession:
GSE231793
ID:
200231793
6.

Genome activity during the emergence of mouse embryonic totipotency

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
55 Samples
Download data: GPR
Series
Accession:
GSE64650
ID:
200064650
7.

Genome activity during the emergence of mouse embryonic totipotency (time course)

(Submitter supplied) Fertilization transforms sperm and egg into a totipotent embryo but the underlying mechanisms are unknown. We here report that gene expression initiates during the gamete-to-embryo transition in mouse embryos. Meiotic exit induced by sperm entry enhances a transcriptionally-permissive epigenetic landscape. Time-course analysis of single embryos revealed a succession of genome-wide transcription 'ripples' initiating within 2 hours. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
24 Samples
Download data: GPR
Series
Accession:
GSE64649
ID:
200064649
8.

Genome activity during the emergence of mouse embryonic totipotency (morpholino)

(Submitter supplied) Fertilization transforms sperm and egg into a totipotent embryo but the underlying mechanisms are unknown. We here report that gene expression initiates during the gamete-to-embryo transition in mouse embryos. Meiotic exit induced by sperm entry enhances a transcriptionally-permissive epigenetic landscape. Time-course analysis of single embryos revealed a succession of genome-wide transcription 'ripples' initiating within 2 hours. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
31 Samples
Download data: GPR
Series
Accession:
GSE64648
ID:
200064648
9.

Transcriptome profiling of left ventricles from Wildtype and KDM5B knockout mice

(Submitter supplied) Myocardial fibrosis is the most common pathological feather of adverse ventricular remodeling, and persistent fibrotic extension decreases myocardial compliance, promotes the development of heart failure. Epigenetics has been considered to play a potent regulatory role in the development of excessive myocardial fibrosis. Although, the explicit mechanism of epigenetic regulation in myocardial fibrosis still needs to be fully elucidated.Transcriptome microarray analysis was used to screen differentially expressed genes in myocardial tissues from KDM5B KO and littermate control WT mice at day 7 after MI operation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
4 Samples
Download data: TXT
Series
Accession:
GSE197223
ID:
200197223
10.

Neuronal activity stimulates astrocyte proliferation through NMDA receptor-dependent induction of Prostaglandin-Endoperoxide Synthase 2

(Submitter supplied) Gene expression analysisis of NR2A and NR2B containing NMDA receptors after treatment with AP5, NVP-AAM077 and Ro25-6981
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
20 Samples
Download data: TXT
Series
Accession:
GSE89802
ID:
200089802
11.

Ethanol and its nonoxidative metabolites promote acute liver injury by inducing ER stress, adipocyte death and lipolysis

(Submitter supplied) We gave mice either a 5g/kg ethanol (EtOH) gavage, a 7g/kg EtOH gavage, or an isocaloric maltose gavage (equivalent to 5g/kg EtOH) in the morning and sacrificed mice 9h later. Microarray analyses were performed on liver tissue from these mice to determine genes and pathways contributing to acute ethanol-induced liver injury. Lipid metabolism-associated genes were found to be dysregulated in both the 5g/kg and 7g/kg groups, with the majority of changes occuring in the 7g/kg group. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
10 Samples
Download data: TXT
Series
Accession:
GSE214778
ID:
200214778
12.

Gene expression signature of DHTKD1 gene knock-out spinal cord

(Submitter supplied) We employed whole genome microarray expression profiling as a discovery platform to identify gene expression changes after DHTKD1 knock-out RNAs of spinal cords of 8-weeks-old wild-type (n=3) and DHTKD1 knock-out mice (n=3) were used to identify gene expression.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
6 Samples
Download data: TXT
Series
Accession:
GSE81735
ID:
200081735
13.

Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury

(Submitter supplied) We altered the NIAAA (Gao Binge Model) of 8 week chronic plus binge ethanol (E8G1) to have 3 total ethanol gavages (5 g/kg; 1 every 24h) of ethanol after 8 weeks of chronic ethanol feeding (E8G3) to determine how the liver responds to chronic plus consecutive binge ethanol. Surprisingly, E8G3 treatment induced lower levels of liver injury, steatosis, inflammation, and fibrosis as compared to mice after E8G1 treatment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
5 Samples
Download data: TXT
Series
Accession:
GSE212755
ID:
200212755
14.

IκBζ-deficient epidermis mediates systemic autoimmune inflammation via skin dysbiosis.

(Submitter supplied) Skin microbiota affect systemic inflammation through mechanisms that have not been completely elucidated. We previously demonstrated that keratinocyte-specific IκBζ-deficient mice spontaneously develop autoimmune inflammation resembling human Sjögren syndrome. In this study, we examined how IκBζ-deficient epidermis dictates systemic autoimmune inflammation onset. To examine if IκBζ-deficient keratinocytes are susceptible to apoptotic stimuli in a steady state, we performed microarray analysis of untreated murine back epidermis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
2 Samples
Download data: TXT
Series
Accession:
GSE165515
ID:
200165515
15.

An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Mustela putorius furo
Type:
Expression profiling by array
Platforms:
GPL7202 GPL32337
112 Samples
Download data: TXT
Series
Accession:
GSE205841
ID:
200205841
16.

An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets [mouse]

(Submitter supplied) Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pandemics as well as from viruses adapted to a variety of animals including poultry, pigs, and horses. Vaccines that broadly protect against all such IAVs, so-called “universal” influenza vaccines, do not currently exist, but are urgently needed. Here, we demonstrated that an inactivated, multivalent whole virus vaccine, delivered intramuscularly or intranasally, was broadly protective against challenges with multiple IAV hemagglutinin and neuraminidase subtypes in both mice and ferrets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
72 Samples
Download data: TXT
Series
Accession:
GSE205839
ID:
200205839
17.

Metabolic disorder and gut microbiota feature in high energy diet

(Submitter supplied) To study dynamic and diversied impacts of fat and sugar.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
9 Samples
Download data: TXT
Series
Accession:
GSE206601
ID:
200206601
18.

Altered transcriptional responses in the lungs of aged mice after influenza infection

(Submitter supplied) This study used transcriptomic analysis to evaluate how aging specifically affects the functional host response to influenza in the mouse lung. Adult (12-16 weeks) and aged (72-76 weeks) female BALB/c mice were infected with influenza (A/Puerto Rico/8/34 (H1N1) (A/PR8)) intranasally (instilled with 50 μl of PBS containing 50-100 pfu PR8). Lungs were processed for RNA expression analysis via Agilent microarray at various time points. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
34 Samples
Download data: TXT, XLSX
Series
Accession:
GSE197596
ID:
200197596
19.

Skin transcriptomics predict outcome after ionizing radiation exposure with potential dosimetric applications in a mouse model

(Submitter supplied) Increased use of nuclear reactors and radioactive materials for energy production and proliferation of nuclear weaponry increases risk of radiation exposure or nuclear accidents. Development of radiation countermeasures for the diagnosis, prognosis, and radiation treatment are trailing behind, and knowledge of the deleterious radiation effects on health and responses to exposure at the molecular, cellular, and systems biology level are still not fully understood. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
82 Samples
Download data: TXT
Series
Accession:
GSE185149
ID:
200185149
20.

Kinetics of M-CSF cultured and LPS stimulated WT and miR-155 KO Macrophages.

(Submitter supplied) Analysis of the transcriptome pattern of miR-155 deficient Bone marrow-derived macrophages (BMMΦ) in both steady-state and inflammatory conditions after 6-, 12- and 24 h, in comparison to their WT counterparts.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
16 Samples
Download data: TXT
Series
Accession:
GSE40029
ID:
200040029
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