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Items: 1 to 20 of 25087

1.

Age-related blood transcriptional regulators affect disease progression in pediatric multiple sclerosis

(Submitter supplied) The more aggressive clinical disease course of Pediatric Onset Multiple Sclerosis(POMS) as compared to Adult Onset Multiple Sclerosis(AOMS) during the first year disease is supported by higher inflammatory potential promoted by transcriptional level of age-associated genes and transcription factors involved in Cell Cycle, B Cell proliferation and senescent mechanisms. Herein, we compared the blood mononuclear cell transcriptome of POMS and AOMS patients during first year disease. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
59 Samples
Download data: CEL
Series
Accession:
GSE203241
ID:
200203241
2.

Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity

(Submitter supplied) Background: Chaperon-mediated autophagy (CMA) has taken on a new emphasis in cancer biology. However, the roles of CMA in hypoxic tumours are poorly understood. We investigated the anti-tumour effects of the natural product ManA through the activation of CMA in tumour progression under hypoxia. Methods: The effect of ManA on CMA activation was assessed in mouse xenograft models and cells. The gene expressions of HIF-1α, HSP90AA1, and transcription factor EB (TFEB) were analysed using The Cancer Genome Atlas (TCGA) datasets to assess the clinical relevance of CMA. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
12 Samples
Download data: CEL
Series
Accession:
GSE110768
ID:
200110768
3.

PDGFRβ signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL20301 GPL24676 GPL571
107 Samples
Download data: BEDGRAPH, CEL, NARROWPEAK
Series
Accession:
GSE239409
ID:
200239409
4.

PDGFRβ signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis [microarray]

(Submitter supplied) Unsupervised clustering of desmoid tumors and normal mesenchymal tissues was performed using henes associated with HIF1 activity. This accurately distiguished neoplastic tissues from normal controls The study sought to identify genes differentially expressed in desmoid-type fibromatosis as opposed to normal mesenchymal tissues. We noted that beta-catenin, the central driver in desmoid-type fibromatosis, appeared to regulate HIF1 signaling in in vitro studies. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
85 Samples
Download data: CEL
Series
Accession:
GSE237692
ID:
200237692
5.

Normalization of Large Scale Transcriptome Data Using Heuristic Methods

(Submitter supplied) We introduce AI method for addressing batch effect of genetic data The method does not rely on any assumptions regarding the distribution and the behavior of data elements. Hence, it does not introduce any new biases in the process of correcting for batch effect. It strictly maintains the integrity of measurements within the original batches.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
216 Samples
Download data: CEL
Series
Accession:
GSE189788
ID:
200189788
6.

The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus [array]

(Submitter supplied) The autoimmune disease lupus erythematosus (lupus) is characterized in part by photosensitivity, where patients can develop inflammatory skin lesions with even ambient ultraviolet radiation (UVR) exposure. Evidence points to a role for type I interferon (IFN-I) in photosensitivity, but mechanistic understanding remains limited. We have shown that photosensitivity in lupus models is at least in part attributable to Langerhans cell (LC) dysfunction. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL571
14 Samples
Download data: CEL, TXT
Series
Accession:
GSE227329
ID:
200227329
7.

The transcriptional response to MESH1 silencing

(Submitter supplied) All organisms are exposed to various stresses, necessitating adaptive strategies for survival and homeostasis. In bacteria, the main stress-coping mechanism is stringent response triggered by the accumulation of the “alarmone” (p)ppGpp to trigger proliferation arrest and transcriptional reprogramming. Mammalian genomes encode MESH1  —the homologue of the (p)ppGpp hydrolase SpoT, with unknown function. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
12 Samples
Download data: CEL
Series
Accession:
GSE135358
ID:
200135358
8.

TAZ overexpression partially rescued the transcriptomic reprogramming triggered by MESH1 silencing

(Submitter supplied) TAZ is an important transcriptional co-activator involved in the HIPPO pathway that regulates cell growth, tumorigenesis and organ development and can play as a key mediator in other signaling pathways, such as MESH1-regulated pathways. MESH1 is the human ortholog of spoT that regulates sringent response in bacteria. MESH1 silencing inhibits cell proliferation and triggers a genome-wide transcriptional reprogramming as how spoT works in bacteria, among which TAZ is significantly down-regulated. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
12 Samples
Download data: CEL
Series
Accession:
GSE135346
ID:
200135346
9.

Gene expression in donor kidney biopsies prior to kidney transplantation

(Submitter supplied) Donor organ shortage, growing waiting lists and organ discard rates are key problems in kidney transplantation. Donor organ quality is a critical factor determining post-transplant graft outcomes. However, organ quality is difficult to predict. Balancing the use of marginal donors without affecting outcomes is a main issue in the transplant field. The decision of acceptance of a kidney organ for transplantation is mainly based on donor organ biopsy findings, even though there are recognized limitations. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
192 Samples
Download data: CEL
Series
Accession:
GSE147451
ID:
200147451
10.

Expression data of Glioma Stem Cells sorted for CD133 and PDPN expression

(Submitter supplied) Expression data of Glioma Stem Cells sorted for CD133 and PDPN expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
14 Samples
Download data: CEL
Series
Accession:
GSE202221
ID:
200202221
11.

MESH1 knockdown triggers proliferation arrest through TAZ repression

(Submitter supplied) All organisms are constantly exposed to various stresses, necessitating adaptive strategies for survival. In bacteria, the main stress-coping mechanism is the stringent response triggered by the accumulation of “alarmone” (p)ppGpp to arrest proliferation and reprogram transcriptome. While mammalian genomes encode MESH1—the homolog of the (p)ppGpp hydrolase SpoT, current knowledge about its function remains limited. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
9 Samples
Download data: CEL
Series
Accession:
GSE147062
ID:
200147062
12.

Gene expression profiles of MCF7 cells treated with NB001

(Submitter supplied) Type 1 adenylyl cyclase (ADCY1) is a main enzyme to produce cyclic AMP (cAMP) upon activation of G-protein coupled receptors and increase of intracellular calcium. It regulates cAMP signaling and in turn affects physiological functions including neural plasticity, cognition, motor function, cell survival, and neuropathic pain. We used microarrays to determine the effect of a known ADCY1 inhibitor NB001 on gene transcription.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
4 Samples
Download data: CEL
Series
Accession:
GSE198111
ID:
200198111
13.

Expression profile of MESH1 and ATF4 silencing RCC4 cells

(Submitter supplied) MESH1 encodes for Metazoan SpoT Homolog 1, which is a homologue of bacterial SpoT that mediates bacterial stringent response. In human cells, we found that MESH1-silencing induces an extensive transcriptional response in clear cell carcinoma cell line RCC4 that partially overlap with mammalian cell integrated stress response (ISR), which ATF4 up-regulation is an essential branch of the response. In this study, the goal is to elucidate the role of ATF4 up-regulation in MESH1-silencing transcriptional response.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
12 Samples
Download data: CEL
Series
Accession:
GSE114128
ID:
200114128
14.

An integrated transcriptomic approach to identify molecular markers of calcineurin inhibitor nephrotoxicity in pediatric kidney transplant recipients

(Submitter supplied) Calcineurin inhibitor nephrotoxicity (CNIT) has been associated with the development of chronic renal allograft dysfunction and decreased graft survival. This study evaluated 37 formalin-fixed paraffin-embedded biopsies from pediatric kidney transplant recipients using gene expression profiling. Oxidative phosphorylation and mitochondrial dysfunction were the top molecular pathways as-sociated with overexpressed genes in CNIT samples. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
37 Samples
Download data: CEL
Series
Accession:
GSE174020
ID:
200174020
15.

Expression data for post-bifurcation internal carotid atheroma

(Submitter supplied) There are regional differences in plaque morphology and mechanistic differences between areas upstream and downstream of the lipid core. Transcript expression profiles were determined for post-bifurcation carotid plaques to identify genes differentially expressed between symptomatic and asymptomatic patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
18 Samples
Download data: CEL
Series
Accession:
GSE111782
ID:
200111782
16.

Transcriptomic characterization of the delayed wound healing response in a diabetic skin humanized mice model

(Submitter supplied) Previously, we developed a new model of diabetes-induced wound healing impairment in skin-humanized mice models that faithfully recapitulates the major histo-physiological features of such skin repair-deficient condition. Aiming to dissect the molecular mechanisms responsible for the delayed wound closure, global gene expression studies were performed.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
26 Samples
Download data: CEL, CHP
Series
Accession:
GSE147890
ID:
200147890
17.

Effect of Age on Severity and Recovery of Acute Multiple Sclerosis Attack

(Submitter supplied) Pediatric MS patients suffer from severe first and second relapse but better recovery explained by difference in age-restricted transcriptional profiles associated with antigen-presentation and B-cell activation Herein, we compared the blood mononuclear cell transcriptome of pediatric and adult MS patients with recovery (PDMS-rec, ADMS-rec) and without recovery (PDMS-norec, ADMS-norec) 6 months after relapse. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
85 Samples
Download data: CEL
Series
Accession:
GSE146383
ID:
200146383
18.

Co-Morbid Multiple Sclerosis and Psoriasis: Clinical Outcomes and Gene Expression

(Submitter supplied) Psoriasis was found to ameliorate multiple sclerosis (MS) outcomes when it MS onset. However, the molecular basis for this observation remains unclear. Herein, we compared the blood mononuclear cell transcriptome of psoriasis and MS comorbide (P/MS) patients with that of patients with either psoriasis or MS to understand the clinical observation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL96 GPL571
55 Samples
Download data: CEL, XLS, XLSX
Series
Accession:
GSE141804
ID:
200141804
19.

Network preservation reveals shared and unique biological processes associated with chronic alcohol abuse in the NAc and PFC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; synthetic construct
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16384 GPL571
70 Samples
Download data: CEL
Series
Accession:
GSE161999
ID:
200161999
20.

Network preservation reveals shared and unique biological processes associated with chronic alcohol abuse in the NAc and PFC [mRNA]

(Submitter supplied) Chronic alcohol abuse has been linked to the disruption of executive function and allostatic conditioning of reward response dysregulation in the mesocorticolimbic pathway (MCL). Here, we analyzed genome-wide mRNA and miRNA expression from matched cases with alcohol dependence (AD) and controls (n=35) via gene network analysis to identify unique and shared biological processes dysregulated in the prefrontal cortex (PFC) and nucleus accumbens (NAc). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
35 Samples
Download data: CEL
Series
Accession:
GSE161986
ID:
200161986
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