GPL33271[RGSE] - GEO DataSets

Select item 2002737511.

Pseudomonas aeruginosa controls both Caenorhabdtitis elegans attraction and pathogenesis by regulating nitrogen assimilation

(Submitter supplied) Detecting chemical signals is important for identifying food sources and avoiding harmful agents. Like many animals, C. elegans use olfaction to chemotax towards their main food source, bacteria. However, little is known about the bacterial compounds governing C. elegans attraction to bacteria and the physiological importance of these compounds to bacteria. Here, we address these questions by investigating the function of a small RNA, P11, in the pathogen, Pseudomonas aeruginosa, that was previously shown to mediate learned pathogen avoidance. more...

Organism:: Pseudomonas aeruginosa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33271
9 Samples

Download data: XLSX

Series

Accession:: GSE273751

ID:: 200273751

Select item 2002678622.

Pseudomonas aeruginosa Activates Quorum Sensing, Antioxidant Enzymes and Type VI Secretion in Response to Oxidative Stress to Initiate Biofilm Formation and Wound Chronicity

(Submitter supplied) Pseudomonas aeruginosa (PA) is an opportunistic pathogen frequently isolated from cutaneous chronic wounds. How PA, in the presence of oxidative stress (OS), colonizes chronic wounds and forms a biofilm is still unknown. The purpose of this study is to investigate the changes in gene expression seen when PA is challenged with the high levels of OS present in chronic wounds. We used a biofilm-forming PA strain isolated from the chronic wounds of our murine model (RPA) and performed a qPCR to obtain gene expression patterns as RPA developed a biofilm in vitro in the presence of high levels of OS, and then compared the findings in vivo, in our mouse model of chronic wounds. more...

Organism:: Pseudomonas aeruginosa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33271
18 Samples

Download data: TXT

Series

Accession:: GSE267862

ID:: 200267862

PubMed Full text in PMC Similar studies

Select item 2002494833.

Antibacterial activities of the algal bromophenol methylrhodomelol against Pseudomonas aeruginosa

(Submitter supplied) Methylrhodomelol (1) is a bromophenol from the red alga Vertebrata lanosa (L.) T.A.Christensen that has been associated with antimicrobial properties. Aim of the current study was therefore, to assess the antimicrobial potential of this compound in more detail against the gram-negative pathogen Pseudomonas aeruginosa. 1 exerted weak bacteriostatic activity against different strains when grown in minimal medium, whereas other phenolics were inactive. more...

Organism:: Pseudomonas aeruginosa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33271
6 Samples

Download data: TXT

Series

Accession:: GSE249483

ID:: 200249483

PubMed Similar studies

Select item 2002498624.

A novel inhibitor of P. aeruginosa folate metabolism exploits metabolic differences for narrow-spectrum antibiotic targeting

(Submitter supplied) Pseudomonas aeruginosa is a leading cause of hospital acquired infections for which the development of new antibiotics is urgently needed. Unlike most enteric bacteria, P. aeruginosa lacks thymidine kinase and thymidine phosphorylase activity, and thus cannot scavenge exogenous thymine. An appealing strategy to selectively target P. aeruginosa while leaving the healthy microbiome largely intact would thus be to disrupt thymidine synthesis while providing exogenous thymine. more...

Organism:: Pseudomonas aeruginosa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33271
3 Samples

Download data: XLSX

Series

Accession:: GSE249862

ID:: 200249862

PubMed Full text in PMC Similar studies

Select item 2002277725.

PhrS pulse expression RNA-seq

(Submitter supplied) A key challenge for understanding the role(s) played by short, non-coding RNAs (sRNAs) in bacteria is identifying the mRNA targets regulated by the sRNAs. Because the Hfq protein mediates the interactions between many sRNAs and the corresponding target mRNAs, one apporach to identify the mRNA targets of sRNAs is to capture sRNA:mRNA interactions occuring on Hfq by exposing cells to UV-irradiation, which forms cross-links between nucleic acids and proteins. more...