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Items: 1 to 20 of 12253

1.

Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset

(Submitter supplied) In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal maturation. However, the degree of cellular similarity across anthropoid foveas and the molecular underpinnings of foveal maturation remain unclear. Here, we used high throughput single cell RNA sequencing (scRNA-seq) to profile retinal cells of the common marmoset (Callithrix jacchus), an early divergent in anthropoid evolution from humans, apes, and macaques. more...
Organism:
Callithrix jacchus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL28240 GPL21580
24 Samples
Download data: BED, MTX, TSV
Series
Accession:
GSE249004
ID:
200249004
2.

Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate motor cortex [marmoset]

(Submitter supplied) Sequence divergence of cis-regulatory elements drives species-specific traits, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains to be elucidated. We investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset, and mouse with single-cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome, and chromosomal conformation profiles from a total of over 180,000 cells. more...
Organism:
Callithrix jacchus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL28240
5995 Samples
Download data: TSV
Series
Accession:
GSE241339
ID:
200241339
3.

Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate motor cortex

(Submitter supplied) Sequence divergence of cis-regulatory elements drives species-specific traits, but how this manifests in the evolution of neocortex at the molecular and cellular level remains to be elucidated. We investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset, and mouse with single cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome and chromosomal conformation profiles from a total of over 180,000 cells. more...
Organism:
Mus musculus; Callithrix jacchus; Macaca mulatta; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
5 related Platforms
46 Samples
Download data: MTX, TSV
Series
Accession:
GSE229169
ID:
200229169
4.

Evolution of neuronal cell classes and types in the vertebrate retina

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mustela putorius furo; Bos taurus; Anolis sagrei; Ictidomys tridecemlineatus; Homo sapiens; Sus scrofa domesticus; Rhabdomys pumilio; Danio rerio; Didelphis marsupialis; Peromyscus maniculatus; Tupaia chinensis; Callithrix jacchus; Ovis aries
Type:
Expression profiling by high throughput sequencing
13 related Platforms
118 Samples
Download data
Series
Accession:
GSE237215
ID:
200237215
5.

Evolution of neuronal cell classes and types in the vertebrate retina [Marmoset]

(Submitter supplied) The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs (Baden et al., 2020). One might expect that retinal cell types evolved to accommodate these varied needs, but this has not been systematically studied. Here, we generated and integrated single-cell transcriptomic atlases of the retina from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a teleost fish, a bird, a reptile and a lamprey. more...
Organism:
Callithrix jacchus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28240
8 Samples
Download data: CSV
Series
Accession:
GSE237206
ID:
200237206
6.

Microenvironment Impacts the Molecular Architecture and Interactivity of Resident Cells in Marmoset Brain

(Submitter supplied) We sought to define and compare the diversity of cells across many brain areas, including various white matter (WM) regions, the volume and complexity of which is limited in mouse brain. We employed magnetic resonance (MR) image-guided sampling and snRNA-seq to survey the transcriptome at cellular resolution. Tissue types included WM (frontal, parietal, temporal), corpus callosum (anterior, posterior), optic tract, cerebral cortex (frontal, parietal, temporal, occipital, cingulate), caudate, hippocampus, lateral geniculate nucleus, cerebellum, thalamus, midbrain, pons, and cervical spinal cord. more...
Organism:
Callithrix jacchus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL28240 GPL26566 GPL18020
42 Samples
Download data: CSV, RDATA
Series
Accession:
GSE165578
ID:
200165578
7.

scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

(Submitter supplied) Adeno-associated virus (AAV)-mediated gene therapies are rapidly advancing to the clinic, and AAV engineering has resulted in vectors with increased ability to deliver therapeutic genes. Although the choice of vector is critical, quantitative comparison of AAVs, especially in large animals, remains challenging. Here, we developed an efficient single-cell AAV engineering pipeline (scAAVengr) to simultaneously quantify and rank efficiency of competing AAV vectors across all cell types in the same animal. more...
Organism:
Callithrix jacchus; Macaca fascicularis; Mus musculus
Type:
Expression profiling by high throughput sequencing
5 related Platforms
147 Samples
Download data: CSV, MTX, TSV, TXT
Series
Accession:
GSE161645
ID:
200161645
8.

Epigenetic landscape of Mammalian Brain M1 by Single Nucleus Methylation Sequencing [MM_M1_2]

(Submitter supplied) Illustrating the cellular architecture of the mammalian brain is critical to understanding its diverse functions and complex animal behaviors. Single nucleus methylation sequencing was applied to M1 regions of human and mouse brains. we identified distinct cell clusters and formed them in a hierarchical taxonomy. These clusters include known primary brain cell types and possible sub-types. We use these data to identify the epigenomic characteristics and to define specific regulatory elements for each cell cluster.
Organism:
Callithrix jacchus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL28240
3043 Samples
Download data: TSV
Series
Accession:
GSE146633
ID:
200146633
9.

Epigenetic landscape of Mammalian Brain M1 by Single Nucleus Methylation Sequencing [MM_M1]

(Submitter supplied) Illustrating the cellular architecture of the mammalian brain is critical to understanding its diverse functions and complex animal behaviors. Single nucleus methylation sequencing was applied to M1 regions of human and mouse brains. we identified distinct cell clusters and formed them in a hierarchical taxonomy. These clusters include known primary brain cell types and possible sub-types. We use these data to identify the epigenomic characteristics and to define specific regulatory elements for each cell cluster.
Organism:
Callithrix jacchus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL28240
3047 Samples
Download data: TSV
Series
Accession:
GSE146608
ID:
200146608
10.

Innovations in primate interneuron repertoire

(Submitter supplied) We report single-nucleus transcriptomes from brain regions in 5 species: mice: Frontal Cortex, V1, Hippocampus, Striatum; common marmoset: 7 neocortical regions, Hippocampus, Striatum (Nucleus Accumbens, Caudate, Putamen); rhesus macaque: Prefrontal Cortex, V1; human: Prefrontal Cortex, V1, Striatum (Caudate); ferret: Prefrontal Cortex, V1, Striatum
Organism:
Callithrix jacchus; Macaca mulatta; Homo sapiens; Mustela putorius furo; Mus musculus
Type:
Expression profiling by high throughput sequencing
8 related Platforms
123 Samples
Download data: TXT
Series
Accession:
GSE151761
ID:
200151761
11.

Illumina NovaSeq 6000 (Callithrix jacchus)

Organism:
Callithrix jacchus
10 Series
12242 Samples
Download data
Platform
Accession:
GPL28240
ID:
100028240
12.

Neonate3, periphery, rep2

Organism:
Callithrix jacchus
Source name:
Retina
Platform:
GPL28240
Series:
GSE249004
Download data: BED, MTX, TSV
Sample
Accession:
GSM8155301
ID:
308155301
13.

Neonate3, periphery, rep1

Organism:
Callithrix jacchus
Source name:
Retina
Platform:
GPL28240
Series:
GSE249004
Download data: BED, MTX, TSV
Sample
Accession:
GSM8155300
ID:
308155300
14.

Neonate3, fovea, rep2

Organism:
Callithrix jacchus
Source name:
Retina
Platform:
GPL28240
Series:
GSE249004
Download data: BED, MTX, TSV
Sample
Accession:
GSM8155299
ID:
308155299
15.

Neonate3, fovea, rep1

Organism:
Callithrix jacchus
Source name:
Retina
Platform:
GPL28240
Series:
GSE249004
Download data: BED, MTX, TSV
Sample
Accession:
GSM8155298
ID:
308155298
16.

Adult3, periphery, NeuN

Organism:
Callithrix jacchus
Source name:
Retina
Platform:
GPL28240
Series:
GSE249004
Download data: MTX, TSV
Sample
Accession:
GSM8155297
ID:
308155297
17.

CEMBA3C_MarmosetM1_R2_P8-6-E22-P24

Organism:
Callithrix jacchus
Source name:
Marmoset_M1C
Platform:
GPL28240
Series:
GSE241339
Download data: TSV
Sample
Accession:
GSM7727457
ID:
307727457
18.

CEMBA3C_MarmosetM1_R2_P8-6-E22-P23

Organism:
Callithrix jacchus
Source name:
Marmoset_M1C
Platform:
GPL28240
Series:
GSE241339
Download data: TSV
Sample
Accession:
GSM7727456
ID:
307727456
19.

CEMBA3C_MarmosetM1_R2_P8-6-E22-P12

Organism:
Callithrix jacchus
Source name:
Marmoset_M1C
Platform:
GPL28240
Series:
GSE241339
Download data: TSV
Sample
Accession:
GSM7727455
ID:
307727455
20.

CEMBA3C_MarmosetM1_R2_P8-6-E22-P11

Organism:
Callithrix jacchus
Source name:
Marmoset_M1C
Platform:
GPL28240
Series:
GSE241339
Download data: TSV
Sample
Accession:
GSM7727454
ID:
307727454
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