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Items: 1 to 20 of 684

1.

A CpG island-encoded mechanism protects genes from premature transcription termination [SET1_TTseq]

(Submitter supplied) Transcription must be highly controlled to regulate gene expression and development. However, our understanding of the molecular mechanisms that influence transcription and how these are coordinated in cells to ensure normal gene expression remains rudimentary. Here, we reveal that actively transcribed CpG island-associated gene promoters recruit SET1 chromatin modifying complexes to enable gene expression. more...
Organism:
Drosophila melanogaster; Mus musculus
Type:
Other
Platform:
GPL25537
18 Samples
Download data: BW, CSV
Series
Accession:
GSE199804
ID:
200199804
2.

A CpG island-encoded mechanism protects genes from premature transcription termination [SET1_RNAseq]

(Submitter supplied) Transcription must be highly controlled to regulate gene expression and development. However, our understanding of the molecular mechanisms that influence transcription and how these are coordinated in cells to ensure normal gene expression remains rudimentary. Here, we reveal that actively transcribed CpG island-associated gene promoters recruit SET1 chromatin modifying complexes to enable gene expression. more...
Organism:
Drosophila melanogaster; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25537
46 Samples
Download data: BW, CSV
Series
Accession:
GSE199803
ID:
200199803
3.

A CpG island-encoded mechanism protects genes from premature transcription termination [SET1_ChIPseq]

(Submitter supplied) Transcription must be highly controlled to regulate gene expression and development. However, our understanding of the molecular mechanisms that influence transcription and how these are coordinated in cells to ensure normal gene expression remains rudimentary. Here, we reveal that actively transcribed CpG island-associated gene promoters recruit SET1 chromatin modifying complexes to enable gene expression. more...
Organism:
Drosophila melanogaster; Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19415 GPL25537 GPL19057
60 Samples
Download data: BED, BW, CSV
Series
Accession:
GSE199801
ID:
200199801
4.

A CpG island-encoded mechanism protects genes from premature transcription termination

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Drosophila melanogaster; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other
Platforms:
GPL19415 GPL19057 GPL25537
124 Samples
Download data
Series
Accession:
GSE199805
ID:
200199805
5.

H3K4 Methylation in β-cells prevents transcriptional downregulation and variance associated with type 2 diabetes.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL25537 GPL19057
30 Samples
Download data: BW, MTX
Series
Accession:
GSE181951
ID:
200181951
6.

H3K4 Methylation in β-cells prevents transcriptional downregulation and variance associated with type 2 diabetes [RNA-seq]

(Submitter supplied) Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes (T2D) and coincides with impaired expression of genes essential to β-cell function, but drivers of gene expression dysregulation are not well resolved. We find that H3K4me3 peak breadth correlates with gene expression dysregulation in T2D. Using an adult β-cell Dpy30-KO mouse model, we show that global reduction of H3K4 methylation causes downregulation of genes also downregulated in T2D. more...
Organism:
Mus musculus; Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL25537
14 Samples
Download data: CSV, FA, MTX, TXT
Series
Accession:
GSE181950
ID:
200181950
7.

H3K4 Methylation in β-cells prevents transcriptional downregulation and variance associated with type 2 diabetes [ChIP-seq]

(Submitter supplied) Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes (T2D) and coincides with impaired expression of genes essential to β-cell function, but drivers of gene expression dysregulation are not well resolved. We find that H3K4me3 peak breadth correlates with gene expression dysregulation in T2D. Using an adult β-cell Dpy30-KO mouse model, we show that global reduction of H3K4 methylation causes downregulation of genes also downregulated in T2D. more...
Organism:
Mus musculus; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25537
16 Samples
Download data: BW
Series
Accession:
GSE181949
ID:
200181949
8.

Distinct roles of CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Drosophila melanogaster; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL19415 GPL25537 GPL19057
148 Samples
Download data: TXT
Series
Accession:
GSE185930
ID:
200185930
9.

Distinct roles for CDK-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction (RNA-Seq)

(Submitter supplied) Precise control of gene expression is essential for normal development. This is thought to rely on mechanisms that enable communication between gene promoters and other regulatory elements. In embryonic stem cells (ESCs) the CDK-Mediator (CDK-MED) complex has been reported to topologically link gene regulatory elements to enable gene expression and also prime genes for induction during differentiation. more...
Organism:
Drosophila melanogaster; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25537
32 Samples
Download data: BW, CSV
Series
Accession:
GSE185929
ID:
200185929
10.

Distinct roles for CDK-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction (ChIP-Seq)

(Submitter supplied) Precise control of gene expression is essential for normal development. This is thought to rely on mechanisms that enable communication between gene promoters and other regulatory elements. In embryonic stem cells (ESCs) the CDK-Mediator (CDK-MED) complex has been reported to topologically link gene regulatory elements to enable gene expression and also prime genes for induction during differentiation. more...
Organism:
Homo sapiens; Mus musculus; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19415 GPL25537 GPL19057
81 Samples
Download data: BW
Series
Accession:
GSE185927
ID:
200185927
11.

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency [RNA-seq]

(Submitter supplied) The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) bind target genes and use histone modification-dependent feedback mechanisms to form Polycomb chromatin domains and repress transcription. The interrelatedness of PRC1 and PRC2 activity at these sites has made it difficult to discover the specific components of Polycomb chromatin domains that drive gene repression and to understand mechanistically how this is achieved. more...
Organism:
Drosophila melanogaster; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25537
21 Samples
Download data: BW, TXT
Series
Accession:
GSE159399
ID:
200159399
12.

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency [ChIP-seq]

(Submitter supplied) The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) bind target genes and use histone modification-dependent feedback mechanisms to form Polycomb chromatin domains and repress transcription. The interrelatedness of PRC1 and PRC2 activity at these sites has made it difficult to discover the specific components of Polycomb chromatin domains that drive gene repression and to understand mechanistically how this is achieved. more...
Organism:
Drosophila melanogaster; Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL25537 GPL19415
154 Samples
Download data: BED, BW
Series
Accession:
GSE159398
ID:
200159398
13.

PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Drosophila melanogaster; Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL25537 GPL19415
175 Samples
Download data: BW
Series
Accession:
GSE159400
ID:
200159400
14.

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL19415 GPL25537
162 Samples
Download data
Series
Accession:
GSE161996
ID:
200161996
15.

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome [RNA-seq]

(Submitter supplied) Histone-modifying systems play fundamental roles in gene regulation and the development of multicellular organisms. Histone modifications that are enriched at gene regulatory elements have been heavily studied, but the function of modifications found more broadly throughout the genome remains poorly understood. This is exemplified by histone H2A monoubiquitylation (H2AK119ub1), which is enriched at Polycomb-repressed gene promoters but also covers the genome at lower levels. more...
Organism:
Mus musculus; Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25537
36 Samples
Download data: BW, TXT
Series
Accession:
GSE161995
ID:
200161995
16.

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome [ATAC-seq]

(Submitter supplied) Histone-modifying systems play fundamental roles in gene regulation and the development of multicellular organisms. Histone modifications that are enriched at gene regulatory elements have been heavily studied, but the function of modifications found more broadly throughout the genome remains poorly understood. This is exemplified by histone H2A monoubiquitylation (H2AK119ub1), which is enriched at Polycomb-repressed gene promoters but also covers the genome at lower levels. more...
Organism:
Mus musculus; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25537
16 Samples
Download data: BW
Series
Accession:
GSE161994
ID:
200161994
17.

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome [ChIP-seq]

(Submitter supplied) Histone-modifying systems play fundamental roles in gene regulation and the development of multicellular organisms. Histone modifications that are enriched at gene regulatory elements have been heavily studied, but the function of modifications found more broadly throughout the genome remains poorly understood. This is exemplified by histone H2A monoubiquitylation (H2AK119ub1), which is enriched at Polycomb-repressed gene promoters but also covers the genome at lower levels. more...
Organism:
Mus musculus; Homo sapiens; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL25537 GPL19415
110 Samples
Download data: BED, BW
Series
Accession:
GSE161993
ID:
200161993
18.

CDK-Mediator and FBXL19 cooperate in the induction of developmental genes by promoting regulatory interactions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL25537 GPL19057
76 Samples
Download data: BW
Series
Accession:
GSE136424
ID:
200136424
19.

CDK-Mediator and FBXL19 cooperate in the induction of developmental genes by promoting regulatory interactions [ChIP-seq]

(Submitter supplied) Appropriate developmental gene regulation relies on the capacity of gene promoters to integrate inputs from distal regulatory elements, yet how this is achieved remains poorly understood. In embryonic stem cells (ESCs), a subset of silent developmental gene promoters are primed for activation by FBXL19, a CpG island binding protein, through its capacity to recruit CDK-Mediator. How mechanistically these proteins function together to prime genes for activation during differentiation is unknown. more...
Organism:
Drosophila melanogaster; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25537
16 Samples
Download data: BW
Series
Accession:
GSE136422
ID:
200136422
20.

PRC2.1 and PRC2.2 synergize to co-ordinate H3K27 tri-methylation. 

(Submitter supplied) Polycomb Repressive Complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di- and tri-methylation of Histone H3 at Lysine 27. While at least two subcomplexes exist, defined by their specific accessory proteins, termed PRC2.1 (Polycomb-like proteins 1-3, EPOP and PALI1/2) and PRC2.2 (AEBP2 and JARID2), little is known about their differential functions. Here, we show that PRC2.1 and PRC2.2 share the majority of target genes in mouse embryonic stem cells (ESCs). The loss of all three Polycomb-like proteins is sufficient to destabilise and evict PRC2.1 from chromatin, but also leads to reduced PRC2.2 and H3K27me3 at most Polycomb domains. However, the combined loss of PRC2.1 and PRC2.2 is necessary to completely remove H3K27me3 at broad Polycomb domains such as the Hox loci. Our data support a model in which the specific accessory proteins within PRC2.1 and PRC2.2 co-operate to direct and maintain H3K27me3, via both synergistic and independent mechanisms.
Organism:
Drosophila melanogaster; Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19415 GPL25537
37 Samples
Download data: BW
Series
Accession:
GSE133412
ID:
200133412
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