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Items: 1 to 20 of 1383

1.

Peripheral Blood Biomarkers in ART-Suppressed, SIV-Infected Rhesus Macaques Predict Viral Rebound Following ART Discontinuation

(Submitter supplied) The development of biomarkers that can predict viral rebound following discontinuation of antiretroviral therapy (ART) in HIV-1-infected humans would be an important advance in HIV-1 cure research. In a prior study, we initiated ART in 20 rhesus macaques on days 0, 1, 2, and 3 following SIVmac251 infection prior to plasma viremia1. Following 6 months of suppressive ART, we discontinued ART and observed viral rebound in 9 of 20 animals. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
105 Samples
Download data: CSV
Series
Accession:
GSE203603
ID:
200203603
2.

Defining prepubertal primate spermatogonial stem cells to address fertility preservation in prepubertal boys

(Submitter supplied) Antineoplastic treatments for cancer and other non-malignant disorders can result in male long-term or permanent infertility by ablating spermatogonial stem cells (SSCs). Preserving the future fertility of prepubertal patients faced with this prospect cannot rely on sperm banking. SSC transplantation using testicular tissue harvested before sterilizing treatment is a promising approach for restoring fertility, but lack of exclusive biomarkers which can unequivocally identify prepubertal SSCs in any primate species limits the therapeutic potential. more...
Organism:
Macaca mulatta; Papio anubis
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL27943 GPL30489 GPL21120
6 Samples
Download data: MTX, TSV
Series
Accession:
GSE222105
ID:
200222105
3.

Gene expression profiling of granuloma T cells in M. tuberculosis infected rhesus macaques reveals a critical role for CD30

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21120 GPL19057
69 Samples
Download data
Series
Accession:
GSE228114
ID:
200228114
4.

Gene expression profiling of granuloma T cells in M. tuberculosis infected rhesus macaques reveals a critical role for CD30 [Macaca mulatta]

(Submitter supplied) Control of Mycobacterium tuberculosis infection requires generation of T cells that migrate to granulomas, complex immune structures surrounding sites of bacterial replication. Here we compared the gene expression profiles of T cells in pulmonary granulomas, bronchoalveolar lavage and blood of Mtb-infected rhesus macaques to identify granuloma-enriched T cell genes. TNFRSF8/CD30 was among the top genes that was upregulated in both CD4 and CD8 granuloma T cells and independent of bacterial loads. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
53 Samples
Download data: CSV
Series
Accession:
GSE227653
ID:
200227653
5.

The Testis-Specific Transcription Factor TCFL5 Responds to A-MYB to Elaborate Male Meiotic Program in Mammals

(Submitter supplied) In the mammalian testis, the pool of spermatogonia is amplified by mitosis before these progenitor germ cells undergo meiosis to generate the haploid cells that give rise to sperm. Extensive changes in the transcriptome accompany the onset of the pachytene stage of meiosis, including the transcriptional activation of meiotic genes, the pachytene piRNA pathway, as well as mRNAs required later during spermiogenesis. more...
Organism:
Macaca mulatta; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL19057 GPL21120
57 Samples
Download data: BW
Series
Accession:
GSE166104
ID:
200166104
6.

MicroRNA profiling of extracellular vesicles isolated from rhesus macaques vaccinated with DNA/ALVAC/gp120 vaccine

(Submitter supplied) We contrasted innate and adaptive immune responses elicited by the DNA/ALVAC/gp120/alum vaccine in non-human primates differing in age. We performed several analyses. MicroRNA profiling in Extracellular Vesicles (EVs) isolated from plasma collected prior and 1 week following vaccination identified 109 miRNAs that differed significantly between age groups at the end of immunization. Several miRNAs correlated with risk of virus acquisition in young and old animals, but none remained significant following correction for FDR. more...
Organism:
Macaca mulatta
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL21120
37 Samples
Download data: TXT
Series
Accession:
GSE188575
ID:
200188575
7.

Nascent transcription upon interferon-α2 stimulation on human and rhesus macaque lymphoblastoid cell lines

(Submitter supplied) Changes in gene transcription regulation are necessary for species to respond to changes in their environment. In particular, host-pathogen dynamics have been observed to entail rapid evolution of genes involved in the host innate immune system. Cytokines such as type I interferon alpha and beta trigger an antiviral cellular state controlled by members of the transcription factor families STAT and IRF. more...
Organism:
Macaca mulatta; Homo sapiens
Type:
Other
Platforms:
GPL21120 GPL18573
12 Samples
Download data: BED, BW
Series
Accession:
GSE214304
ID:
200214304
8.

RNA seq for CD4 T cells in lymph nodes from rhesus macaques

(Submitter supplied) We evaluated transcriptional profiling of CD4 T cells from mesenteric and genital lymph nodes following SIV infection by RNA-seq.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
34 Samples
Download data: CSV
Series
Accession:
GSE165519
ID:
200165519
9.

High-throughput Ig and TCR repertoire single-cell sequencing analysis in rhesus macaques

(Submitter supplied) Recent advancements in microfluidics and high-throughput sequencing technologies have enabled recovery of paired heavy- and light- chain of immunoglobulins (Ig) and VDJ- and VJ- chains of T cell receptors (TCR) from thousands of single cells simultaneously. Due to the complexity of these polyclonal receptors, for many species single-cell immune repertoire sequencing assays are not yet commercially available. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
5 Samples
Download data: H5
Series
Accession:
GSE179722
ID:
200179722
10.

IL15 in treatment of rhesus macaques

(Submitter supplied) Rhesus macaques vaccinated by rhesus cytomegalovirus vectors expressing simian immunodeficiency virus proteins (RhCMV/SIV) activate gene expression signature associated with IL15. To examine the gene expression signature activated by IL15, we performed longitudinal examinations of rhesus macaques during IL15 treament.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
60 Samples
Download data: TXT
Series
Accession:
GSE160577
ID:
200160577
11.

Host response to RhCMV/SIV immunization through subcutaneous and oral route

(Submitter supplied) Strain 68-1–derived Rhesus Cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that stringently control and subsequently clear a mucosal challenge with highly pathogenic SIV in 50-60% of vaccinated rhesus monkeys (RMs). Here, we utilize whole blood transcriptomic profiling to identify host responses correlated to RhCMV/SIV efficacy.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
403 Samples
Download data: CSV
Series
Accession:
GSE160562
ID:
200160562
12.

A molecular census of midbrain dopaminergic neurons in Parkinsons disease

(Submitter supplied) Midbrain dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) project widely throughout the central nervous system, playing critical roles in voluntary movements, reward processing, and working memory. Many of these neurons are highly sensitive to neurodegeneration in Parkinson’s Disease (PD), and their loss correlates strongly with the pathognomonic symptoms. To characterize these populations molecularly, we developed a protocol to enrich and transcriptionally profile DA neuron nuclei from postmortem human SNpc of both PD patients and matched controls. more...
Organism:
Macaca mulatta; Homo sapiens; Tupaia belangeri; Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
4 related Platforms
101 Samples
Download data: MTX, TSV
Series
Accession:
GSE178265
ID:
200178265
13.

RNA sequencing analysis of lung samples of control and irradiated animals

(Submitter supplied) Purpose: Radiation-induced lung injury (RILI) is a progressive condition, with an early phase, radiation pneumonitis (RP), and a late phase, lung fibrosis (LF). RILI may occur after partial body ionizing radiation exposures or by internal radioisotope exposure, with wide individual variability in timing and extent of lung injury. This study aims to provide new insights into the pathogenesis and progression of RILI in the non-human primate (NHP) rhesus macaque model. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
30 Samples
Download data: CSV
Series
Accession:
GSE174196
ID:
200174196
14.

Transcriptome analysis reveals the contribution of glia -derived cues for maintenance of microglia identity in rhesus macaques

(Submitter supplied) We analyzed the transcriptomes of different primary microglia cultures from adult rhesus macaques, and compared them with those of ex vivo microglia
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL27943 GPL21120
52 Samples
Download data: CSV, TSV, TXT
Series
Accession:
GSE171476
ID:
200171476
15.

MicroRNA signatures of the developing primate fovea

(Submitter supplied) Purpose: Uncover the mRNA and microRNA signatures of non-human primate retina during development.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL21120
16 Samples
Download data: XLSX
Series
Accession:
GSE168475
ID:
200168475
16.

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination

(Submitter supplied) Vaccination against tuberculosis by intradermal Bacillus Calmette-Guérin (BCG) injection saves many lives, supposedly by inducing adaptive immune memory in lymphocytes. Epidemiologically, BCG vaccination is also associated with reduced childhood mortality unrelated to TB, which is attributed to innate immune memory, also termed trained immunity. We recently demonstrated improved protection against tuberculosis infection in highly susceptible rhesus macaques by mucosal BCG vaccination, correlating with a unique local but no peripheral immune profile. more...
Organism:
Macaca mulatta
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21120
6 Samples
Download data: BIGWIG
Series
Accession:
GSE159046
ID:
200159046
17.

Transcriptomic profiling of primed and naive primate pluripotent stem cells by RNA-sequencing

(Submitter supplied) Analysis of rhesus monkey ESC cells that have been reprogrammed to naïve pluripotency using 7 different protocols including, TL2i, 4i/L/b, E-NHSM, NHSM-v, t2iLGöY, LCDM (EPS), TL-CDK8/19i and compared to primed cells.
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21120
27 Samples
Download data: CSV
Series
Accession:
GSE146178
ID:
200146178
18.

Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes

(Submitter supplied) In the male germ cells of eutherian animals, 26–30-nt-long PIWI-interacting RNAs (piRNAs) emerge when spermatocytes enter the pachytene phase of meiosis. These pachytene piRNAs derive from ~100 discrete autosomal loci resemble canonical protein-coding genes and long non-coding RNA-producing genes—they are transcribed by RNA polymerase II, bearing 5´ caps and 3´ poly(A) tails, and their transcripts often contain introns that are removed before nuclear export and processing into piRNAs. more...
Organism:
Mus musculus; Macaca mulatta
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL21120
19 Samples
Download data: BW
Series
Accession:
GSE147724
ID:
200147724
19.

An endogenous retrovirus-derived long non-coding RNA promotes fetal cardiomyocyte migration in primates

(Submitter supplied) The protein-coding gene networks regulating heart development are well known. Less understood are the roles of long non-coding RNAs (lncRNAs), many of which are poorly conserved due to their origins from transposable elements (TEs) such as endogenous retroviruses (ERVs). Here, we report hundreds of ERV elements from the primate-specific MER41 family are expressed in pluripotent cell-derived cardiomyocytes and fetal heart, some of which are regulated by the cardiogenic transcription factor TBX5. more...
Organism:
Macaca mulatta; Pan troglodytes; Gorilla gorilla; Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
7 related Platforms
60 Samples
Download data: BW, HIC, TDF, TXT
Series
Accession:
GSE111930
ID:
200111930
20.

RNA sequence of PBMCs of macaques infected with SARS-CoV-2

(Submitter supplied) The goals of this study are to analyze immune response of host against SARS-CoV-2 using PBMCs trascriptome
Organism:
Macaca mulatta; Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL22523 GPL21120
16 Samples
Download data: TXT
Series
Accession:
GSE152439
ID:
200152439
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