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Items: 1 to 20 of 303667

1.

Sperm transcriptional state associated with paternal transmission of stress phenotypes

(Submitter supplied) Paternal stress can induce long-lasting changes in germ cells potentially propagating heritable changes across generations. To date, no studies have investigated differences in transmission patterns between stress-resilient and -susceptible mice. We tested the hypothesis that transcriptional alterations in sperm during chronic social defeat stress (CSDS) transmit increased susceptibility to stress phenotypes to the next generation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
58 Samples
Download data: TXT
Series
Accession:
GSE174780
ID:
200174780
2.

The role of CD4 T cells in tumor-specific CD8 T cell reprogramming [ATAC-Seq]

(Submitter supplied) ATAC-seq analysis of tumor-specific CD8 T cells from tumors with and without tumor-specific CD4 T cells
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: BW, CSV, NARROWPEAK
Series
Accession:
GSE265847
ID:
200265847
3.

The role of CD4 T cells in tumor-specific CD8 T cell reprogramming [RNA-Seq]

(Submitter supplied) RNA-seq analysis of tumor-specific CD8 T cells from tumors with and without tumor-specific CD4 T cells
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
7 Samples
Download data: COUNTS
Series
Accession:
GSE265846
ID:
200265846
4.

Transcriptomic Landscape of Hras12V Oncogene-Induced Hepatocarcinogenesis with Gender Disparity

(Submitter supplied) The genesis of hepatocellular carcinoma (HCC) is closely related to hyper-activated Ras signals and male factors. This study aimed to characterize the underlying mechanisms by examining the transcriptome of Hras12V transgenic mice (Ras-Tg, HCC model). A transcriptomic database was established via RNA-Seq of HCC (T) and the adjacent precancerous liver tissue (P) of Ras-Tg and the normal liver tissue of wild-type mice (W) of both sexes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE232694
ID:
200232694
5.

Transcriptome changes after overexpression, knockdown and condItional knockout of UXT in mice

(Submitter supplied) Ubiquitously expressed transcript (UXT) has been shown to play a role in regulating the process of autophagy. Here, we investigated roles of UXT in the innnate immune responses after overexpression, knockdown and condItional knockout of UXT in mice
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: TXT
Series
Accession:
GSE175928
ID:
200175928
6.

Lack of TREM2 during anti-PD-1 therapy reprograms intestinal macrophages and microbiota to enhance tumor rejection

(Submitter supplied) The gut microbiota and tumor-associated macrophages (TAM) impact anti-PD-1 checkpoint blockade. Reprogramming TAM by either blocking or deleting the macrophage receptor TREM2 attenuates tumor growth, and lack of functional TREM2 enhances tumor elimination by anti-PD-1. Here, we found that anti-PD-1 combined with TREM2 deficiency induces proinflammatory programs in intestinal macrophages and a concomitant expansion of Ruminococcus gnavus (R. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
32 Samples
Download data: MTX, TSV
Series
Accession:
GSE262811
ID:
200262811
7.

PTEN-L induce PTEN-null tumor cells dormancy but lung outgrowth.

(Submitter supplied) PTEN is one of the most frequently mutated tumor suppressor genes, its loss has been reported in multiple tumor types and is associated with a poor outcome. PTEN-L, as a secreted isoform of PTEN, with the ability to enter cells and inhibit tumor cell growth via inhibiting AKT mediated cell proliferation. However, the distinct effect of PTEN-L on PTEN-expression or PTEN-loss tumor cells is not known yet. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: XLS
Series
Accession:
GSE246600
ID:
200246600
8.

Liver gene expression analysis of male ApoE-/- mice treated with Isoginkgetin

(Submitter supplied) Isoginkgetin (ISOGK) is a biflavone derived from Ginkgo Biloba that inhibits RNA splicing. ISOGK has been reported to have various protective effects, including anti-inflammatory, antioxidant, and anti-tumorigenic properties. The study aimed to investigate the impact of ISOGK treatment on atherosclerosis induced by a Western diet in ApoE-/- mice. After seven weeks of a high-fat diet, ISOGK was administered intraperitoneally for eight weeks. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: TXT
Series
Accession:
GSE261858
ID:
200261858
9.

FOXA1 and FOXA2 binding profile in mouse colon [ChIP]

(Submitter supplied) FOXA1 and FOXA2 are essentail transcription factors for proper gut development. In adults, they play a role in the differentiation of intestinal secretory cells and were also reporeted to directly activate Muc2 transcription. Here we show that FOXA1 and FOXA2 bind near goblet cell genes, and are specifically enriched near glycosylation genes. Deletion of these transcription factors in mouse intestine leads to a downregulation of glycosylation genes in the colon and to a massive change of the colonic surface glycans. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: BW, TXT
Series
Accession:
GSE263629
ID:
200263629
10.

Study of the tRNA-derived fragment expression profile in mouse pancreatic islets of pre-diabetic obese db/db mice

(Submitter supplied) In this study, we discovered cytosolic and mitochondrial fragments resulting from tRNA and mt-tRNA cleavage, which may act as new regulators of cellular and metabolic functions. We analyzed hundreds of these fragments in the pancreatic islets of db/db mice and compared them to heterozygous control db/+ mice. At 16 weeks of age, db/db mice exhibit obesity, insulin resistance, and glucose intolerance. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: XLSX
Series
Accession:
GSE239786
ID:
200239786
11.

ILC2 development requires GATA3-related super-enhancers after lineage commitment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Group 2 innate lymphoid cells (ILC2) are a subset of innate lymphocytes that produce type 2 cytokines, including IL-4, IL-5, and IL-13. GATA3 being a critical transcription factor for ILC2 development at multiple stages. However, when and how GATA3 is induced to the levels required for ILC2 development remains elusive. Herein, we identified ILC2-specific tandem GATA3-related super-enhancers (G3SE) that induce high GATA3 in ILC2-committed precursors. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL19057 GPL17021
17 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE218155
ID:
200218155
12.

H3K27ac ChIP-seq for lung ILC2 and CD4 T cells in HDM induced asthma

(Submitter supplied) Lung ILC2 and Th2 cells exhibited similar chromatin activation. However, small fraction of super-enhancers showed ILC2-specific, or T cell specific activation.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: BEDGRAPH
Series
Accession:
GSE218144
ID:
200218144
13.

Endothelial Pd1 orchestrates cerebrovasculature homeostasis and oligodendrogenesis during brain development

(Submitter supplied) Purpose: To explore further into the mechanisms by which endothelial PD1 controls cerebrovascular development and oligodendrogenesis, we employed RNA-seq to examine genome-wide alterations in endothelial cells from P0 conditional PD1 knockout mice, comparing them with their wild-type littermates. Methods: mRNA was extracted from P0 isolated endothelial cells of Pd1fl/fl and Pd1cKO-Tie2 mice, and the quality and quantity were assessed using the Agilent 2100 Bioanalyzer. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: XLS
Series
Accession:
GSE267172
ID:
200267172
14.

Relaxin Attenuates the Genomic Actions and Biological Effects of Estrogens in the Myometrium by Reducing Estrogen Receptor Alpha Phosphorylation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL19057
40 Samples
Download data
Series
Accession:
GSE244843
ID:
200244843
15.

Relaxin Attenuates the Genomic Actions and Biological Effects of Estrogens in the Myometrium by Reducing Estrogen Receptor Alpha Phosphorylation [ChIP-seq]

(Submitter supplied) In this study we examine the extent and nature of functional interactions between the E2 and Rln signaling pathways in the myometrium. In addition, we delineate the mechanisms underlying functional interplay between the E2/ERα and Rln/RXFP1 signaling pathways at the molecular and physiological levels in myometrial tissue and cells during quiescence and contractility.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
32 Samples
Download data: BW
Series
Accession:
GSE244841
ID:
200244841
16.

Pericytes and perivascular fibroblasts contribute to central nervous system fibrosis in a region dependent manner

(Submitter supplied) Fibrotic scar tissue formation is conserved throughout the central nervous system in humans and mice, and impairs tissue regeneration and functional recovery. However, the origin of scar-forming stromal fibroblasts is controversial. Here, we show that stromal fibroblasts found after spinal cord injury derive from two populations of perivascular cells that are anatomically and transcriptionally defined as pericytes and perivascular fibroblasts. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
832 Samples
Download data: CSV, TXT
Series
Accession:
GSE229916
ID:
200229916
17.

UBXN9 inhibits the RNA exosome function to promote T cell control of liver tumorigenesis

(Submitter supplied) To explore the function of UBXN9 in regulating liver tumorigenesis, we generated UBXN9-overexpressing and control LPC-HRas liver tumor cells by using lentivirus. Then, the mRNAs derived from these two groups of cells, including two replicates for each group , were subjected to RNA-seq.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE232053
ID:
200232053
18.

Blinding of virus-specific CXCR6+ CD8 T cells in the liver during chronic viral hepatitis causes loss of effector function

(Submitter supplied) Chronic viral hepatitis after infection with hepatotropic viruses like hepatitis B virus (HBV) affects 300 million persons worldwide, which as the result of chronic immune-mediated hepatic inflammation cause liver cirrhosis and cancer being responsible for 800.000 deaths per year3. Chronic viral hepatitis is maintained by failure of the host´s immune response to control viral infection, but the mechanisms for this inability of virus-specific CD8 T cells to eliminate HBV-infected hepatocytes remain unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
16 Samples
Download data: CSV, TSV, TXT, YAML
Series
Accession:
GSE212925
ID:
200212925
19.

miRNA expression data from exosomes of cardiopulmonary progenitors (CPPs) isolated and cultured in vitro

(Submitter supplied) Cardiopulmonary progenitors (CPPs) derived from mouse embryos have multi-directional differentiation potential. Their exosomes are not be investigated yet.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
1 Sample
Download data: TXT
Series
Accession:
GSE231987
ID:
200231987
20.

Single-cell RNA sequencing of adult mouse fibrotic kidney induced by unilateral uretral obstruction

(Submitter supplied) We performed single-cell RNAseq for adult mouse fibrotic kidney to characheterize how epithelial to mesenchymal transition program is implemented at single tubular cells resolution during the course of renal intrestitial fibrosis
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
3 Samples
Download data: MTX, RDS, TSV
Series
Accession:
GSE175412
ID:
200175412
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