GPL16791[Accession] - GEO DataSets

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Select item 2002493771.

Exploring the Effects of Experimental Parameters and Data Modeling Approaches on In Vitro Transcriptomic Point-of-Departure Estimates

(Submitter supplied) Multiple new approach methods (NAMs) are being developed to rapidly screen large numbers of chemicals to aid in hazard evaluation and risk assessments. High-throughput transcriptomics (HTTr) in human cell lines has been proposed as a first-tier screening approach for determining the types of bioactivity a chemical can cause (activation of specific targets vs. generalized cell stress) and for calculating transcriptional points of departure (tPODs) based on changes in gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
5670 Samples

Download data: CSV

Series

Accession:: GSE249377

ID:: 200249377

Select item 2002455832.

Pivotal role of mitochondria in development and treatment of severe phenotypes of desmin-mutated cardiomyocytes from a patient with myofibrillar myopathy

(Submitter supplied) Desmin-related myofibrillar myopathy, a severe muscle disease, is caused by mutations in the desmin-encoding gene, leading to skeletal myopathies and/or cardiomyopathy. Although previous studies suggested that desmin mutations alter the cellular structure and mitochondria function in myocyte, the pathophysiological mechanism by which mutated desmin impairs cardiac function has been poorly explored in physiologically relevant human disease models. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE245583

ID:: 200245583

Select item 2002165303.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
41 Samples

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Series

Accession:: GSE216530

ID:: 200216530

Select item 2002165284.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer [RNA-Seq 3]

(Submitter supplied) To investigate the function of VGLL1 in breast cancer and its role in the resistance to endocrine therapies we generated stable MCF7 cells overexpressing VGLL1 using CRISPR/Cas9 Synergistic Activation Mediator (SAM) method (MCF7 ActCas9-VGLL1 cells). MCF7 ActCas9-VGLL1 cells were also cultured in the presence of fulvestrant 100nmM or 1µM to develop fulvestrant resistant cells (MCF7 ActCas9-VGLL1-FULVR) and RNA-seq was performed in the different cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE216528

ID:: 200216528

Select item 2002165275.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer [RNA-Seq 2]

(Submitter supplied) To identify VGLL1 target genes we performed RNA-seq following siRNA-mediated VGLL1 downregulation in FULVR cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE216527

ID:: 200216527

Select item 2002165266.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer [RNA-Seq 1]

(Submitter supplied) To investigate if the drug verteporfin can inhibit VGLL1 co-transcriptional activity in Fulvestrant resistant breast cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
8 Samples

Download data: TXT

Series

Accession:: GSE216526

ID:: 200216526

Select item 2002165257.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer [ChIP-Seq]

(Submitter supplied) The transcriptional activity of the TEAD4 trascription factor requires co-activators. In this study we found that the expression of the TEAD coactivator VGLL1 is repressed in estrogen receptor positive breast cancer but upon resistance to endocrine threapies VGLL1 is expressed to high levels. To elucidate the importance of the coactivator VGLL1 in breast cancer cells resistant to endocrine therapies and to identify the VGLL1 target genes, we performed ChIP-seq for VGLL1 in MCF7 breast cancer cells resistant to fulvestrant (FULVR) and ChiP-seq for TEAD4 in FULVR cells and the isogenic MCF7 cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
9 Samples

Download data: BED

Series

Accession:: GSE216525

ID:: 200216525

Select item 2002492258.

RNA-seq profiling of epidermal tissues of visually younger and older women in the Youngster-Oldie (Y-O) study

(Submitter supplied) Skin, with its distinctive features and visible signs of aging, provides a remarkable model for studying the aging process. The variable rate of skin aging among individuals provides a valuable opportunity to capture a wide range of age-related changes. In this study, we used bulk RNA sequencing (RNA-seq) to explore the diverse skin characteristics of individuals with both older and younger appearances.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
25 Samples

Download data: TSV

Series

Accession:: GSE249225

ID:: 200249225

Select item 2002489919.

MicroRNAs in Nasal Lavage Extracellular Vesicles as Potential Therapeutic Targets for Mucus Hypersecretion

(Submitter supplied) Small RNA sequencing was conducted to identify the miRNAs responsible for AR using exosomes isolated from the nasal lavage (NAL) fluid of the control (n=9) and AR patient groups (n=8).

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
18 Samples

Download data: XLSX

Series

Accession:: GSE248991

ID:: 200248991

Select item 20023955810.

A conserved transcriptional program for MAIT cells across mammalian evolution

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus; Monodelphis domestica; Homo sapiens; Bos taurus; Mus musculus; Ovis aries

Type:: Expression profiling by high throughput sequencing

6 related Platforms
10 Samples

Download data: MTX, TSV

Series

Accession:: GSE239558

ID:: 200239558

Select item 20023955611.

A conserved transcriptional program for MAIT cells across mammalian evolution [Hsapiens_thymus_NKT]

(Submitter supplied) Mucosal-Associated Invariant T (MAIT) cells recognize the riboflavin pathway-derived metabolite 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU) presented by the MHC-Ib molecule MR1. Both MR1 and the T cell receptor genes used by MAIT cells are under strong evolutionary pressure in mammals, suggesting an important role of 5-OP-RU-specific T cells across species. In humans and mice, MAIT cells acquire distinctive effector functions linked to the expression of the master transcription factor ZBTB16 (PLZF) during thymic development. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE239556

ID:: 200239556

Select item 20023954812.

A conserved transcriptional program for MAIT cells across mammalian evolution [Hsapiens_thymus_Tconv]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE239548

ID:: 200239548

Select item 20023954413.

A conserved transcriptional program for MAIT cells across mammalian evolution [Hsapiens_thymus_MAIT]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE239544

ID:: 200239544

Select item 20022090614.

Transcriptome analysis of SAP30BP knockdown cells

(Submitter supplied) Examination of transcriptome of SAP30BP knockdown cells by Ribosomal RNA depleted RNA-Seq

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: BEDGRAPH

Series

Accession:: GSE220906

ID:: 200220906

Select item 20018464715.

Androgen receptor signalling driving cancer stem cells (CSCs) state in triple-negative breast cancer

(Submitter supplied) Therapeutic strategies that improve survival outcomes for advanced-stage breast cancers have proven a major clinical challenge. Here, we define an androgen receptor signalling network that governs the maintenance and de novo formation of cancer stem cells in triple-negative breast cancer. In response to chemotherapy, androgen receptor activation switches cells into a cancer stem cell state, while androgen receptor antagonism suppresses cancer stem cell formation and function. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
23 Samples

Download data: CSV

Series

Accession:: GSE184647

ID:: 200184647

SRA Run Selector

Select item 20024751316.

TLR2 promotes tumour proliferation in KRAS-dependant PDAC in the absence of ARF6

(Submitter supplied) Metastasis is responsible for nearly 90% of all cancer-related deaths. Despite global efforts to prevent aggressive tumours, cancers such as pancreatic ductal adenocarcinoma (PDAC) are poorly diagnosed in the primary stage, resulting in lethal metastatic disease. RAS mutations are known to promote tumour spread, with mutant KRAS present in almost 90% of cases. Until recently, mutant KRAS remained untargeted and, despite the recent development of inhibitors, results show that tumour cells develop resistance. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
72 Samples

Download data: CSV

Series

Accession:: GSE247513

ID:: 200247513

Select item 20023018917.

Nuclear release of eIF1 globally increases translation initiation stringency during mitosis

(Submitter supplied) Regulated translation initiation has the potential to reshape the proteome, but conditions under which start codon selection is altered remain poorly defined. Here, using global translation initiation site profiling, we reveal widespread changes in start codon selection during the mammalian cell cycle. Low-efficiency initiation sites are preferentially repressed in mitosis, resulting in changes in the relative translation of thousands of annotated proteins, alternative translational isoforms, and uORFs. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
24 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE230189

ID:: 200230189

Select item 20024849018.

Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1–HIF-2α axis

(Submitter supplied) Chondrosarcomas represent the second most common primary bone malignancy. Despite the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD+) depletion, targeting the NAD+ synthesis pathway remains challenging due to broad implications in biological processes. Here, we establish SIRT1 as a central mediator reinforcing the dependency of chondrosarcoma cells on NAD+ metabolism via HIF-2α-mediated transcriptional reprogramming. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE248490

ID:: 200248490

Analyze with GEO2R

Select item 20023221119.

Transcriptional response to gut pathobiont Streptococcus gallolyticus subsp. gallolyticus infection of huham colon cells

(Submitter supplied) Streptococcus gallolyticus sp. gallolyticus (SGG) is a gut pathobiont involved in the development of colorectal cancer (CRC). To decipher SGG contribution in tumor initiation and/or acceleration respectively, a global transcriptome was performed in normal colonic cells (FHC) and in tumoral colonic cells (HT29). To identify SGG-specific alterations, we chose the phylogenetically closest relative, Streptococcus gallolyticus subsp. more...