GPL16284[Accession] - GEO DataSets

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Select item 2001571111.

Genome-wide DNA methylation profiles of Arsenic exposed subjects through drinking water in Pakistan

(Submitter supplied) Ground water Arsenic (As) toxicity is a global problem and millions of people are exposed to elevated levels (more than WHO advised maximum limit of 10µg/L) through drinking water. The exposure is associated with various cancerous and non-cancerous diseases. It may alter DNA methylation profiles of inviduals and suppress the activity of various genes giving rise to different diseases. Pakistan, a developing country in South Asian region, also has reported elevated ground water As levels in various investigations since 2005. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
57 Samples

Download data: PAIR, TXT

Series

Accession:: GSE157111

ID:: 200157111

PubMed Similar studies

Select item 2000842502.

Induction of changes in primary human hepatocytes by valproic acid

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array; Non-coding RNA profiling by array

Platforms:: GPL16770 GPL16356 GPL16284
35 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE84250

ID:: 200084250

Select item 2000841893.

Induction of DNA methylation changes in primary human hepatocytes by valproic acid

(Submitter supplied) Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug. However, exposure to VPA may cause accumulation of lipids in the liver which could result in the development of steatosis. As VPA is a fatty acid analogue, most of the performed studies focus on inhibition of the mitochondrial b-oxidation pathway as the possible mode of action. However, investigations exploring the contribution of other processes in particular by using whole genome studies in a relevant human liver model are limited. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
12 Samples

Download data: PAIR, TXT

Series

Accession:: GSE84189

ID:: 200084189

PubMed Similar studies

Select item 2000711234.

MeDIP assay using human myometrium of women with preterm labor of different phenotypes vs. normal term labor

(Submitter supplied) Preterm birth is multifactorial in origin with several distinct clinical phenotypes of differing etiologies, including idiopathic preterm birth. Preterm birth involves the interaction of genetic, societal and environmental factors such as nutrition, lifestyle and stress that may modulate the length of gestation via the epigenome. DNA methylation is a well-studied epigenetic modification whereby promoter methylation commonly represses gene expression and vice versa. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
6 Samples

Download data: GFF, PAIR

Series

Accession:: GSE71123

ID:: 200071123

PubMed Similar studies

Select item 2000697695.

MeDIP and hMeDIP assays using human placentas of obese and lean (healthy weight) pregnancies

(Submitter supplied) Maternal obesity has both a direct effect on the outcome of pregnancy but also programs the fetus for obesity and metabolic syndrome in later life. Due to its roles at the interface between mother and fetus, the placenta transduces and mediates the effects of the obese intrauterine environment on the fetus. Here we have generated genome-scale high-resolution maps of 5mC and 5hmC in human placentas of obese and healthy weight pregnancies. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
4 Samples

Download data: GFF, PAIR

Series

Accession:: GSE69769

ID:: 200069769

PubMed Full text in PMC Similar studies

Select item 2000842816.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL18402 GPL17996 GPL16284
53 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE84281

ID:: 200084281

Select item 2000842767.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis (MeDIP)

(Submitter supplied) Cyclosporine A (CsA), is an endecapeptide with strong immunosuppressant activities and has contributed significantly towards clinical progress in organ transplantation. Furthermore, it has various toxic effects in the kidney and especially in the liver where it may induce cholestasis. The CsA drug-induced cholestasis (DIC) pathway includes important genes involved in the uptake, synthesis, conjugation and secretion of bile acids, which can be verified also in hepatic models in vitro. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
18 Samples

Download data: PAIR, TXT

Series

Accession:: GSE84276

ID:: 200084276

PubMed Similar studies

Select item 2000715498.

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL18402 GPL16284 GPL17996
18 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE71549

ID:: 200071549

Select item 2000715489.

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma [DNA methylation]

(Submitter supplied) Chronic exposure to aflatoxin B1 (AFB1) has, in certain regions in the world, been strongly associated with the development of hepatocellular carcinoma (HCC). AFB1 is a very potent hepatotoxic and carcinogenic mycotoxin which is frequently reported as a food contaminant. Epigenetic modifications provoked by environmental exposures, such as AFB1, may create a so called persistent "epigenetic memory" or "footprint". more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
6 Samples

Download data: PAIR, TXT

Series

Accession:: GSE71548

ID:: 200071548

PubMed Similar studies

Select item 20006707810.

Aflatoxin B1 exposure induces epigenetic mechanisms in primary human hepatocytes revealing novel biological processes associated with hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL16284 GPL18402 GPL17996
31 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE67078

ID:: 200067078

Select item 20006700511.

Aflatoxin B1 exposure induces epigenetic mechanisms in primary human hepatocytes revealing novel biological processes associated with hepatocellular carcinoma (MeDIP)

(Submitter supplied) The study investigated differential gene expression, microRNA expression and DNA methylation changes in a pool of primary human hepatocyte RNA and DNA following 5 days of repetitive exposure to a low or moderate dose of aflatoxin B1 or DMSO. Three biological replicates per compound/solvent. In total 9 arrays.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL16284
9 Samples

Download data: PAIR, TXT

Series

Accession:: GSE67005

ID:: 200067005

PubMed Similar studies

Select item 20006398912.

Dynamic interplay between the transcriptome and methylome in response to oxidative and alkylating stress

(Submitter supplied) Methyl radicals are not able to form 5'methylcytosine directly. However, tert-butylhydroperoxide-induced responses in the transcriptome are partly regulated by the methylome to restore normal cellular function

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
18 Samples

Download data: PAIR, TXT

Series

Accession:: GSE63989

ID:: 200063989

Select item 20006802813.

The alteration of DNA methylation driven by HIV infection based on a pair of monozygotic twins (MeDIP-chip)

(Submitter supplied) In this study, we have investigated the relationship between genome-wide DNA methylation pattern and HIV infection using the methylated DNA immunoprecipitation - microarray method. A pair of monozygotic twins was recruited: one of the twins was infected with HIV while the other was not. The immunoprecipitated CpG-methylated DNA from HIV positive subject (test) and from HIV negative subject (input control) were labelled with Cy5 and Cy3 respectively

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
1 Sample

Download data: PAIR

Series

Accession:: GSE68028

ID:: 200068028

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004417414.

Sodium arsenite induced changes in A549 human epithelial lung carcinoma cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL16356 GPL16284
48 Samples

Download data: CEL, PAIR

Series

Accession:: GSE44174

ID:: 200044174

Select item 20004417315.

Sodium arsenite induced DNA methylation changes in A549 human epithelial lung carcinoma cells

(Submitter supplied) Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16284
24 Samples

Download data: PAIR

Series

Accession:: GSE44173

ID:: 200044173

Select item 20004343516.

Thymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation

(Submitter supplied) A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA methylation promote cardiac dysfunction in human dilated cardiomyopathy.