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Items: 1 to 20 of 150

1.

Concurrent DNA copy number alterations and mutations in genes related to maintenance of genome stability in uninvolved glandular tissue from breast cancer patients

(Submitter supplied) Somatic mosaicism for DNA copy number alterations (SMC-CNA) is defined as gain or loss of chromosomal segments in mitotic cells within a single organism. As cells harboring SMC-CNA have the potential to undergo clonal expansion, SMC-CNA may be present in a substantial portion of cells in differentiated human tissues and may contribute to the predisposition of these cells to genetic disease including cancer. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL15436 GPL19457 GPL16707
180 Samples
Download data: PAIR
Series
Accession:
GSE63623
ID:
200063623
2.

DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions

(Submitter supplied) Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains;), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
25 related Platforms
993 Samples
Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, PAIR, TSV, TXT
Series
Accession:
GSE51334
ID:
200051334
3.

Esophageal Cancer Project

(Submitter supplied) Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC). Currently, there are limited clinical approaches for early diagnosis and treatment for ESCC, resulting in a 10% 5-year survival rate for the patients. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL15436 GPL8736
123 Samples
Download data: PAIR, TXT
Series
Accession:
GSE54995
ID:
200054995
4.

a-CGH of Esophageal Cancer (53 cases)

(Submitter supplied) Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC). Currently, there are limited clinical approaches for early diagnosis and treatment for ESCC, resulting in a 10% 5-year survival rate for the patients. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL15436
53 Samples
Download data: PAIR, TXT
Series
Accession:
GSE54994
ID:
200054994
5.

Lack of genetic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases

(Submitter supplied) Lymph-node (LN) metastases predict for high recurrence rates in breast cancer patients. Eradication of micro-metastatic tumor cells is the primary goal of adjuvant systemic treatment. Decisions regarding systemic treatment depend largely on primary tumor characteristics rather than on characteristics of their LN metastases. However, it remains unclear to what extent LN metastases, having already metastasized locally, resemble their primary breast tumors and as such will be eradicated by the systemic therapy chosen. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platforms:
GPL14965 GPL15436
42 Samples
Download data: PAIR
Series
Accession:
GSE38888
ID:
200038888
6.

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

(Submitter supplied) Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be defined by gene expression profiling. However, even within these defined subtypes, heterogeneity prevails. To further elucidate the pathogenesis of these entities, we determined the expression of the tumor suppressor phosphatase and tensin homolog (PTEN) in 248 primary DLBCL patient samples. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
Platforms:
GPL16869 GPL15436 GPL10558
55 Samples
Download data: CEL, PAIR, TXT
Series
Accession:
GSE45495
ID:
200045495
7.

MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma

(Submitter supplied) MCL1 is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL) is unclear. We analyzed gene expression profiling data from 350 DLBCL patient samples and detected that activated B-cell-like (ABC) DLBCLs express MCL1 at significantly higher levels compared to germinal center B-cell-like (GCB) DLBCL patient samples (p=2.7 x 10(-10)) [PMID 23257783]. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL15436
13 Samples
Download data: PAIR, TXT
Series
Accession:
GSE43272
ID:
200043272
8.

Abnormal Developmental Control of Replication Timing Domains in Pediatric Acute Lymphoblastic Leukemia

(Submitter supplied) Abnormal replication timing has been observed in cancer but no study has comprehensively evaluated this misregulation. We generated genome-wide replication timing profiles for pediatric leukemias from 17 patients and 3 cell lines, as well as normal B and T cells. Non-leukemic EBV-transformed lymphoblastoid cell lines displayed highly stable replication timing profiles that were more similar to normal T cells than to leukemias. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL15436
40 Samples
Download data: PAIR
Series
Accession:
GSE37987
ID:
200037987
9.

NimbleGen Human CGH 3x720K Whole-Genome Tiling v3.0 Array [090527_HG18_WG_CGH_v3.1_HX3]

(Submitter supplied) Build: Hg18, NCBI 36 Design name : 090527_HG18_WG_CGH_v3.1_HX3 Design ID: 10033 Protocol: see manufacturer's web site www.nimblegen.com
Organism:
Homo sapiens
8 Series
141 Samples
Download data: GFF, NCD, NDF, POS
Platform
Accession:
GPL15436
ID:
100015436
10.

947H

Organism:
Homo sapiens
Source name:
uninvolved glandular tissue (channel 1) peripheral blood leukocytes (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554009
ID:
301554009
11.

943T

Organism:
Homo sapiens
Source name:
primary tumor (channel 1) peripheral blood leukocytes (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554008
ID:
301554008
12.

903T

Organism:
Homo sapiens
Source name:
primary tumor (channel 1) peripheral blood leukocytes (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554007
ID:
301554007
13.

943M

Organism:
Homo sapiens
Source name:
lymph node metastasis (channel 1) peripheral blood leukocytes (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554006
ID:
301554006
14.

652T

Organism:
Homo sapiens
Source name:
primary tumor (channel 1) uninvolved glandular tissue (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554005
ID:
301554005
15.

903M

Organism:
Homo sapiens
Source name:
lymph node metastasis (channel 1) peripheral blood leukocytes (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554004
ID:
301554004
16.

901H

Organism:
Homo sapiens
Source name:
uninvolved glandular tissue (channel 1) peripheral blood leukocytes (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554003
ID:
301554003
17.

912M

Organism:
Homo sapiens
Source name:
lymph node metastasis (channel 1) uninvolved glandular tissue (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554002
ID:
301554002
18.

640M

Organism:
Homo sapiens
Source name:
lymph node metastasis (channel 1) uninvolved glandular tissue (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554001
ID:
301554001
19.

912T

Organism:
Homo sapiens
Source name:
primary tumor (channel 1) uninvolved glandular tissue (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1554000
ID:
301554000
20.

640T

Organism:
Homo sapiens
Source name:
primary tumor (channel 1) uninvolved glandular tissue (channel 2)
Platform:
GPL15436
Series:
GSE63623
Download data: PAIR
Sample
Accession:
GSM1553999
ID:
301553999
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