GEO DataSets

(Submitter supplied) Induced pluripotent stem cells (iPSCs) are regarded as a central tool to understand human biology in health and disease. Similarly, iPSCs from closely related species should be a central tool to understand human evolution and to identify conserved and variable patterns of iPSC disease models. Here, we have generated human, gorilla, bonobo and cynomolgus monkey iPSCs. We show that these cells are well comparable in their differentiation potential and generally similar to human, cynomolgus and rhesus monkey embryonic stem cells (ESCs). more...

Organism:

Pan paniscus; Macaca mulatta; Gorilla gorilla; Homo sapiens; Macaca fascicularis

Type:

Expression profiling by high throughput sequencing

5 related Platforms

23 Samples

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(Submitter supplied) Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. more...

Organism:

Gorilla gorilla; Homo sapiens; Mus musculus; Gallus gallus; Ornithorhynchus anatinus; Macaca mulatta; Pan paniscus; Pan troglodytes; Pongo pygmaeus; Monodelphis domestica

Type:

Expression profiling by high throughput sequencing

10 related Platforms

131 Samples

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