GPL13112[Accession] - GEO DataSets

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Select item 2002247981.

Genome wide assessment alpha and beta cells from lean and obese mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
30 Samples

Download data: TXT

Series

Accession:: GSE224798

ID:: 200224798

Select item 2002247972.

Genome wide assessment of gene expression in alpha and beta cells from lean and obese mice

(Submitter supplied) We report the assessment of transcriptome by RNA-Seq of FACS purified Ins1-H2bmCherry purified primary mouse beta cells and Gcg-CreERT2 x YFP positive alpha cells of obese (ob/ob) mice compared to lean littermate controls

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
30 Samples

Download data: TXT

Series

Accession:: GSE224797

ID:: 200224797

Select item 2002239213.

Alloantigen Infusion Selectively Activates the Transcriptome of Type 2 Conventional Dendritic Cells"

(Submitter supplied) Recent studies have revealed novel molecular mechanisms by which innate monocytic cells acutely recognize and respond to alloantigen, and the significance of this to allograft rejection and immunologic tolerance. What remains unclear is the single cell heterogeneity of the innate allo-response, and particularly the contribution of dendritic cell (DC) subsets. To investigate the acute response of innate immune cells and DC subsets to exposure of alloantigen, experimental rodents were administered an intravenous injection of live allogenic cells versus isogenic cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
5 Samples

Download data: MTX, TSV

Series

Accession:: GSE223921

ID:: 200223921

Select item 2002400424.

A novel viral tool designed with enhancer-driven gene expression (EDGE) technology allows specific labelling of cell types in wild type rodents

(Submitter supplied) The mammalian brain contains an unimaginable number of neurons, who are all intricately connected to form complex neuronal circuits. Neurons that exhibit similar properties are often defined as belonging to the same cell-type, which can be determined for example by analysing the genetic profile of the cells. A key aspect of studying brain function on a circuit level is the ability to target specific cell types, but this necessitates sophisticated molecular and genetic tools. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL19057
79 Samples

Download data: RDATA

Series

Accession:: GSE240042

ID:: 200240042

Select item 2002220925.

Pregnancy Outcomes in Mouse Dams Exposed to Arsenic: The Role of CYR61 m6A Modification

(Submitter supplied) This study aimed to investigate the effects of gestational As exposure on placental and fetal development, and its underlying mechanisms. We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different placental tissue

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: XLSX

Series

Accession:: GSE222092

ID:: 200222092

PubMed Full text in PMC Similar studies

Select item 2002073286.

Gene expression profile (RNAseq) of peritoneal mouse macrophages in Endotoxic shock and Tolerance

(Submitter supplied) Purpose: Characterize the gene expression profile of of peritoneal mouse macrophages in Endotoxic shock and Tolerance through RNA sequencing Methods: RNA sequencing of RNA from peritoneal macrophages in Endotoxic shock and Tolerance isolated by peritoneal lavage and FACS sorting (F4/80+ CD11b+) Results: Endotoxic shock and Tolerance peritoneal mouse macrophages display differential gene expression. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
18 Samples

Download data: TXT, XLS

Series

Accession:: GSE207328

ID:: 200207328

Select item 2002231367.

The endometrial trasccriptome transition accompanying acquisition of receptivity to embryo implantation in mice

(Submitter supplied) Receptivity of the uterus is essential for embryo implantation and progression of pregnancy. Acquisition of receptivity involves major molecular and cellular changes in the endometrial lining of the uterus from its non-receptive state at ovulation, to its receptive state four days later. The precise molecular mechanisms underlying this transition remain to be fully characterized. Here, we aimed to generate a comprehensive profile of the uterine transcriptome in the peri-ovulatory and peri-implantation states, and to define the differences between them, in the mouse. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
19 Samples

Download data: TSV

Series

Accession:: GSE223136

ID:: 200223136

Select item 2001867508.

Transcriptome profiling from Wild Type and PLSCR1 transgenic mouse(PLSCR1-TG)retina with acute ocular hypertension (AOH) treatment reveals the potential mechanism involved in glaucoma

(Submitter supplied) Glaucoma is a leading cause of irreversible blindness worldwide. In pathogenesis of glaucoma, the molecular mechanisms remain largely unknown. Phospholipid scramblase 1 (PLSCR1) is a key regulator promoting RGCs apoptosis and their clearance by microglia. As evidenced in RGCs of PLSCR1 transgenic mice model treated with acute ocular hypertension, transcriptome profiling from Wild Type and PLSCR1 transgenic mouse(PLSCR1-TG)retina with AOH treatment would reveal the potential mechanism involved in glaucoma.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE186750

ID:: 200186750

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002227769.

Comparative RNA-Seq transcriptome analyses of diabetic nerve and kidney disease II

(Submitter supplied) Diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN) are common complications of type 1 (T1D) and type 2 (T2D) diabetes. However, the mechanisms underlying the development and progression of these complications are unclear. Thus, the goal of the current study was to use system biology approaches to examine DKD and DPN pathogenesis in T1D and T2D mouse models on the same genetic background. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
48 Samples

Download data: TXT

Series

Accession:: GSE222776

ID:: 200222776

Select item 20015563910.

Genomic binding of wild-type and mutant Trp53 in mouse breast cancer cell lines

(Submitter supplied) TP53 is one of the most frequently mutated gene in breast cancer. While p53 mutations often lead to loss of wild-type p53 activity, they can have a wide variety of gain-of-function (GOF) consequences. The impact of these GOF mutations in p53 on the anti-tumor immune response in breast cancer remains elusive. To address this, we have generated mouse mammary tumor models based on orthotopic injection of isogenic cell lines harboring the p53 mutations that most frequently occur in human breast cancer. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
18 Samples

Download data: NARROWPEAK

Series

Accession:: GSE155639

ID:: 200155639

SRA Run Selector

Select item 20008646111.

Genome-wide analysis of HMGA2 and H3K27me3 deposition in neocortical neural stem cells and transcriptome of Wild Type and Ring1 KO neocortical neural stem cells

(Submitter supplied) We examined the dynamic changes of H3K27me3 and gene expression in neocortical neural stem cells directly isolated from various stages of embryonic brains. ChIP-seq of HMGA2 protein in the early stage of neural stem cell, and transcriptome analysis of Ring1A-/-;Ring1Bf/f and Ring1A-/-;Ring1B-/- were also performed.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL13112 GPL11002
35 Samples

Download data: BIGWIG

Series

Accession:: GSE86461

ID:: 200086461

SRA Run Selector

Select item 20024196512.

Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection

(Submitter supplied) Older adults have diminished immune responses that increase susceptibility to infectious diseases, such as influenza (flu). In older adults, flu infection can lead to hospitalization, catastrophic disability, and mortality. We previously demonstrated severe and prolonged muscle degradation and atrophy in aged mice during flu infection. Here, we utilized an unbiased transcriptomic analysis to elucidate mechanisms of flu-induced muscular declines in a mouse model. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
154 Samples

Download data: CSV

Series

Accession:: GSE241965

ID:: 200241965

Select item 20022052013.

Resolvin D1 attenuated liver injury caused by chronic ethanol and acute LPS challenge in mice

(Submitter supplied) Alcohol-associated liver disease (ALD) is a major health problem with limited effective treatment options. Alcohol-associated hepatitis (AH) is a subset of severe ALD with a high rate of mortality due to infection, severe inflammation, and ultimately multi-organ failure. There is an urgent need for novel therapeutic approaches to alleviate the human suffering associated with this condition. Resolvin D1 (RvD1) promotes the resolution of inflammation and regulates immune responses. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
36 Samples

Download data: TXT

Series

Accession:: GSE220520

ID:: 200220520

PubMed Similar studies

Select item 20021688114.

Ablation of dual specificity phosphatase 6 protects against non-alcoholic fatty liver disease via CYP4A and MAPK

(Submitter supplied) Dual specificity phosphatase 6 (DUSP6) is a specific phosphatase for mitogen-activated protein kinase (MAPK). In this study, we used a high-fat diet (HFD)-induced murine non-alcoholic fatty liver disease (NAFLD) model to investigate the role of DUSP6 in this disease. Wild-type (WT) and Dusp6-haploinsufficient (HI) mice developed severe obesity and liver pathology consistent with NAFLD when exposed to HFD. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: XLSX

Series

Accession:: GSE216881

ID:: 200216881

Select item 20013780915.

Endocan-PDGFRα mediated signaling drives glioblastoma spatial heterogeneity and influences tumor vasculature/radioresistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21103 GPL13112
10 Samples

Download data: NARROWPEAK

Series

Accession:: GSE137809

ID:: 200137809

Select item 20013780816.

Endocan-PDGFRα mediated signaling drives glioblastoma spatial heterogeneity and influences tumor vasculature/radioresistance [RNA-seq]

(Submitter supplied) The goal of this project was to study the difference in GBM tumors formed in ESM1 Knockout vs. WT mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: CSV

Series

Accession:: GSE137808

ID:: 200137808

SRA Run Selector

Select item 20023769817.

Ezh2, Utx and Jmjd3 deletion on the H3k27me3 level in mouse chondrocytes

(Submitter supplied) The level of H3K27me3 were examined by conditional knockout Ezh2, Utx or Jmjd3 in mouse chondrocyte

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE237698

ID:: 200237698

Select item 20021807118.

Correlation between electrophysiological impact and the transcriptomic profile of brain metastases

(Submitter supplied) we obtained the individual transcriptomic profiles of the three tested models (482N1, B16F10BrM and E0771BrM) and evaluated whether their different impact on brain functional readouts (i.e., LFP, calcium activity) might have a specific correlate on gene expression.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
9 Samples

Download data: TXT

Series

Accession:: GSE218071

ID:: 200218071

Select item 20019318919.

Amphiregulin couples IL1RL1+ regulatory T cells and cancer-associated fibroblasts to inhibit antitumor immunity

(Submitter supplied) We demonstrated that IL-33 induced strong CD8+ T cell antitumor immune responses characterized by robust clonal expansion and vigorous functional diversification. Nonetheless, IL-33 also produced intense regulatory T cell (Treg) accumulation in the TME, dominated by the IL1RL1+ Treg subset. We further showed that IL1RL1 signaling in Treg cells greatly dampened the antitumor activity of IL-33.