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Items: 1 to 20 of 4400

1.

Modeling myelodysplastic syndromes in mice by altered Hoxa1 spliceform expression (CMP)

(Submitter supplied) The homeobox gene, Hoxa1, has two different isoforms generated by alternative splicing: a full-length homeodomain-containing Hoxa1 (Hoxa1-FL), and a truncated Hoxa1 (Hoxa1-T), that lacks the homeodomain. Oncoretroviral overexpression of wildtype Hoxa1 cDNA (WT-Hoxa1), which generates both Hoxa1 isoforms, in murine hematopoietic stem and progenitor cells (HSPCs) perturbed hematopoiesis, resulting in myelodysplastic syndromes (MDS) in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
11 Samples
Download data: CEL
Series
Accession:
GSE227775
ID:
200227775
2.

Modeling myelodysplastic syndromes in mice by altered Hoxa1 spliceform expression

(Submitter supplied) The homeobox gene, Hoxa1, has two different isoforms generated by alternative splicing: a full-length homeodomain-containing Hoxa1 (Hoxa1-FL), and a truncated Hoxa1 (Hoxa1-T), that lacks the homeodomain. Oncoretroviral overexpression of wildtype Hoxa1 cDNA (WT-Hoxa1), which generates both Hoxa1 isoforms, in murine hematopoietic stem and progenitor cells (HSPCs) perturbed hematopoiesis, resulting in myelodysplastic syndromes (MDS) in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
11 Samples
Download data: CEL
Series
Accession:
GSE62853
ID:
200062853
3.

Short-chain fatty acid-induced changes in colonic gene expression depend on dietary fat content in mice

(Submitter supplied) Background: Acetate, propionate, and butyrate are the main short-chain fatty acids (SCFA) produced in the colon as a result of microbial fermentation of dietary fibers. An increasing amount of evidence suggests that these SCFA have major health benefits. The composition of the microbiota is altered by dietary fat, and this is believed to impact SCFA production. Currently it is unknown whether host gene expression responses to SCFA are modulated by fat content of the diet. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
31 Samples
Download data: CEL
Series
Accession:
GSE48856
ID:
200048856
4.

An integrative map of transcriptional responses to exercise in non-muscle organs

(Submitter supplied) Global gene expression was measured with Affymetrix in seven organs after 3 weeks swimming and control (non swimming) C57BL6 male mice, 14wks old ( by the end of the study). We used microarrays to detail the global programme of gene expression indicative of adaptatie changes occuring in seven tissues, skeletal muscle (quadricepts), liver, kidney, subcutaneous and visceral white adipose tissues, spleen, brain, after 3 weeks of swimming
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
54 Samples
Download data: CEL
Series
Accession:
GSE70655
ID:
200070655
5.

NRF2/KEAP1 in hepatocytes controls fibro- and carcinogenesis in chronic liver disease

(Submitter supplied) Background & Aims: Inflammation in chronic liver diseases induces oxidative stress and thus may contribute to progression of liver injury, fibrosis, and carcinogenesis. The KEAP1/NRF2 axis is a major regulator of cellular redox balance. In the present study, we investigated whether the KEAP1/NRF2 system is involved in liver disease progression in human and mice. Methods: The clinical relevance of oxidative stress was investigated in a well-characterized cohort of NAFLD patients (n=63) by liver RNA sequencing and correlated with histological and clinical parameters. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
24 Samples
Download data: CEL
Series
Accession:
GSE156838
ID:
200156838
6.

Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance and hepatice steatosis in mice.

(Submitter supplied) Cyclic AMP-responsive element-binding protein H (CREBH, encoded by Creb3l3) is a transcription factor that regulates the expression of genes that control lipid and glucose metabolism, as well as inflammation. CREBH is upregulated in the liver under conditions of overnutrition, and mice globally lacking the gene (CREBH-/-) are highly susceptible to diet-induced obesity, insulin resistance (IR) and hepatic steatosis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
6 Samples
Download data: CEL
Series
Accession:
GSE173548
ID:
200173548
7.

Whole-body-vibration training positively affects muscle transcriptome in tumour bearing cachectic mice

(Submitter supplied) Background The prevailing view is that a combination of nutritional, pharmacological and exercise therapy is most optimal to reduce the development and progression of cancer cachexia. However, in many cancer patients, physical activity is hampered by frailty and fatigue. The present study aimed to investigate whole-body vibration training (WBV) as potential alternative to attenuate loss of weight, muscle mass and function in tumour bearing mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
58 Samples
Download data: CEL
Series
Accession:
GSE121972
ID:
200121972
8.

Hepatocytic c-Jun N-terminal kinases (JNK)-1/2 function determines cell fate during carcinogenesis

(Submitter supplied) Aberrant biliary hyperproliferation resulting from lack of differentiating signals favoring the maintenance of an immature and proliferative phenotype by biliary epithelial cells are ultimately responsible for ducto/cystogenesis and intrahepatic cholangiocarcinoma (CCA) formation. Mitogen-activated protein kinase (MAPK) signaling is pivotal for CCA-related tumorigenesis. In particular, targeted inhibition of JNK signaling has shown therapeutic potential. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
24 Samples
Download data: CEL
Series
Accession:
GSE140498
ID:
200140498
9.

Industrial trans fatty acids stimulate SREBP2-mediated cholesterogenesis and promote non-alcoholic fatty liver disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL17400 GPL11533
32 Samples
Download data: CEL
Series
Accession:
GSE136354
ID:
200136354
10.

Industrial trans fatty acids stimulate SREBP2-mediated cholesterogenesis and promote non-alcoholic fatty liver disease [liver]

(Submitter supplied) Scope: Consumption of industrial trans fatty acids unfavourably alters plasma cholesterol and has been linked to NAFLD. However, the mechanisms underlying these deleterious effects of trans fatty acids are unclear. Here, we aim to investigate the molecular mechanisms of action of industrial trans fatty acids. Methods & Results: Hepa1-6 hepatoma cells were incubated with elaidate, oleate, or palmitate. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
24 Samples
Download data: CEL
Series
Accession:
GSE136271
ID:
200136271
11.

Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model

(Submitter supplied) Pulmonary arterial hypertension (PAH) is characterized by remodelling of the pulmonary arteries and right ventricle (RV), which leads to functional decline of cardiac and skeletal muscle. This study investigated the effects of a multi-targeted nutritional intervention with extra protein, leucine, fish oil and oligosaccharides on cardiac and skeletal muscle in PAH. PAH was induced in female C57BL/6 mice by weekly injections of monocrotaline (MCT) for 8 weeks. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
9 Samples
Download data: CEL
Series
Accession:
GSE125537
ID:
200125537
12.

Malignant transformation of normal mature mouse B cells into myeloma-like cells in vitro using defined genetic elements

(Submitter supplied) Expression of MYC+BMI1+BCLXL in normal mature mouse B cells results inmalignant transformation into lymphoma-like cells Expression of MYC+BMI1+BCLX+IRF4 in normal mature mouse B cells results in malignant transformation into myeloma-like cells
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
7 Samples
Download data: CEL
Series
Accession:
GSE122883
ID:
200122883
13.

Expression data from adipose stromal cells

(Submitter supplied) Adipose stromal cells are adipocytes progenitors lying in the stroma vascular fraction of adipose tissue. They can also be released into the circulation upon dietary challenges. We used microarrays to compare the global programme of gene expression between adipose stromal cells originating from murine subcutaneous and perigonadal adipose depots
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
6 Samples
Download data: CEL, XLSX
Series
Accession:
GSE127928
ID:
200127928
14.

Toll-like receptors 2 and 4 control adaptive β-cell expansion in diet-induced obesity

(Submitter supplied) Adult pancreatic β cells are refractory to proliferation, a roadblock for the treatment of insulin-deficient diabetes. Consumption of energy-dense Western or high-fat diet (HFD) triggers mild adaptive β cell mass expansion to compensate for peripheral insulin resistance; however, the underlying molecular mechanism remains unclear. Here we show that Toll-like receptors (TLR) 2/TLR4 act as molecular “brakes” for diet-induced β cell replication in both mice and humans. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
14 Samples
Download data: CEL
Series
Accession:
GSE101392
ID:
200101392
15.

Expression data from FIRE deficient mice

(Submitter supplied) We used microarrays to examine changes in gene expression in the absence of the FIRE enhancer of Csf1r in mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
12 Samples
Download data: CEL
Series
Accession:
GSE108207
ID:
200108207
16.

Liver X Receptor α Activation Enhances Cholesterol Secretion in Lactating Mammary Epithelium

(Submitter supplied) We profiled differential gene expression in vivo between pregnant day 14 (secretory differentiation) and lactation day 4 (established secretory activation) using isolated mouse mammary epithelial cells depleted of the mammary adipocytes. Liver-X-Receptors are ligand-dependent transcription factors activated by cholesterol metabolites. These receptors induce a suite of target genes required for de novo synthesis of triglycerides and cholesterol transport in many tissues. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
8 Samples
Download data: CEL, XLSX
Series
Accession:
GSE121819
ID:
200121819
17.

Expression data from Inferior Vena Cava ligation in WT and Cd39-/- mice

(Submitter supplied) Leukocyte flux contributes to thrombus formation in deep veins under pathologic conditions, but mechanisms which inhibit venous thrombosis are incompletely understood. Ectonucleotide di(tri)phosphohydrolase 1 (ENTPD1 or Cd39), an ectoenzyme which catabolizes extracellular adenine nucleotides, is embedded on the surface of endothelial cells and leukocytes. We hypothesized that under venous stasis conditions CD39 regulates inflammation at the vein:blood interface in a murine model of deep vein thrombosis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
4 Samples
Download data: CEL
Series
Accession:
GSE125965
ID:
200125965
18.

Transcriptional profiling of PPARα-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

(Submitter supplied) Peroxisome Proliferator-Activated receptor α (PPARα) and cAMP-Responsive Element Binding Protein 3-Like 3 (CREB3L3) are transcription factors involved in the regulation of lipid metabolism in the liver. The aim of the present study was to characterize the interrelationship between PPARα and CREB3L3 in regulating hepatic gene expression. Male wildtype, PPARα-/-, CREB3L3-/- and combined PPARα/CREB3L3-/- mice were subjected to a 16-hour fast or 4 days of ketogenic diet. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
30 Samples
Download data: CEL
Series
Accession:
GSE121096
ID:
200121096
19.

The role of Gch1 and Nos2 in the macrophage response to BCG infection

(Submitter supplied) Inducible nitric oxide synthase (iNOS) plays a crucial role in controlling growth of mycobacteria, presumed to be via nitric oxide (NO) mediated killing. However, NOS enzymes can also signal through NO-independent pathways, and production of NO by NOS requires the cofactor tetrahydrobiopterin (BH4). We compared Nos2-/- mice to mice with macrophage BH4 deficiency (Gch1fl/flTie2cre), due to a leukocyte-specific deletion of Gch1, to uncover the specific contribution of NO-independent NOS functions to anti-mycobacterial immunity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
31 Samples
Download data: CEL
Series
Accession:
GSE107543
ID:
200107543
20.

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

(Submitter supplied) Maresin 1 administered to mice prior to orthopedic surgery exerts distinct anti-inflammatory and pro-resolving effects through regulation of MΦ infiltration, NF-κB signaling, and cytokine release. We used microarrays to detail the global programme of gene expression underlying Maresin 1 effect on mouse hippocampus and identified distinct classes of dysregulated genes during this process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
9 Samples
Download data: CEL
Series
Accession:
GSE115440
ID:
200115440
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