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Items: 1 to 20 of 722

1.

Transcriptomic Profiling of Trophoblast Fusion Using BeWo and JEG-3 Cell Lines

(Submitter supplied) Introduction: In human placenta, alteration in trophoblast differentiation has a major impact on placental maintenance and integrity. Moreover, abnormal syncytial fusion seems to be implicated in the development of many complications including pre-eclampsia and intra-uterine growth restriction (IUGR). However, little is known about the mechanisms that control cytotrophoblast fusion into syncytiotrophoblast. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
12 Samples
Download data: CEL
Series
Accession:
GSE127170
ID:
200127170
2.

Gene expression profile of endothelial cell cultures exposed to uremic serum from Chronic Kidney Disease patients: role of MAPK signaling pathway

(Submitter supplied) Transcriptome analysis of human coronary arterial endothelial cells (HCAEC) primary cultures exposed to uremic serum from patients with stage 4-5 cardiovascular diseases (CKD) without myocardial infarction (USI) and stage 4-5 CKD with myocardial infarction (UCI). Gene expression profile of human coronary arterial endothelial cells (HCAEC) primary cultures exposed to uremic serum from of patients with chronic kidney disease (CKD) that explore which pathways are involved in in the development of cardiovascular disease. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE125898
ID:
200125898
3.

BAL cell gene expression is predictive of Mortality in Idiopathic Pulmonary Fibrosis and enriched for Genes of Airway Basal Cells (III)

(Submitter supplied) Background: We got interested whether genes of airway basal cells are enriched in sarcoidosis. Methods: Bronchoscopy with bronchoalveolar lavage (BAL) was performed in 26 patients with sarcoidosis, chest-x-ray type III and IV, and 20 healthy donors and isolated BAL cells.Transcriptome of BAL cells were studied by using Affymetrix Human Affymetrix Whole-Transcript Human Gene 1.0 ST array on an Affymetrix platform. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
46 Samples
Download data: CEL
Series
Accession:
GSE73394
ID:
200073394
4.

BAL cell gene expression is predictive of Mortality in Idiopathic Pulmonary Fibrosis and enriched for Genes of Airway Basal Cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
4 related Platforms
321 Samples
Download data: CEL, TXT
Series
Accession:
GSE70867
ID:
200070867
5.

Molecular heterogeneity of NK/T-cell lymphoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; synthetic construct
Type:
Expression profiling by array; Non-coding RNA profiling by array; Genome variation profiling by SNP array
4 related Platforms
142 Samples
Download data: CEL, OSCHP
Series
Accession:
GSE90784
ID:
200090784
6.

Molecular heterogeneity of NK/T-cell lymphoma (expression)

(Submitter supplied) To investigate if biologically distinct subsets exists in extranodal NK/T-cell lymphoma (NKTL), we performed unsupervised integrative analyses of gene expression profiling (GEP), miRNA profiling, and copy number aberration (CNA) on 66 cases of NKTL from diverse anatomical sites. This series is the GEP data.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
66 Samples
Download data: CEL
Series
Accession:
GSE90597
ID:
200090597
7.

Upregulation of Interferon-inducible and damage response pathways in chronic graft-versus-host disease

(Submitter supplied) To identify systemic cytokine patterns in Chronic Graft-versus-Host-Disease (CGVHD), we profiled the gene expression of circulating monocytes. Pathway analysis identified two gene sets that were significantly upregulated across a broad range of patients with inflammatory and sclerotic presentations: (1) genes induced by Type I and Type II IFN, and (2) receptor genes for innate immune responses to cellular damage. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
36 Samples
Download data: CEL
Series
Accession:
GSE60674
ID:
200060674
8.

mRNA profiling in gastric cancer cell line AGS upon miR-25-3p silencing

(Submitter supplied) Genome-wide mRNA expression profiling was performed in AGS, gastric cancer cell line, upon miR-25 silencing. At 48 hours upon anti-miR-25-3p (miRNA inhibitor) and non-targeting control RNA transfection, the whole transcriptome profiling was performed in triplicates. The miR-25 silencing elevates the diffuse gastric cancer features like expression of COL1A2, expression of COL1A2 co-expressed genes, Epithelial to Mesenchymal Transition (EMT) and angiogenesis associated genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
6 Samples
Download data: CEL
Series
Accession:
GSE84196
ID:
200084196
9.

Tyrosine Kinase Inhibitor Cardiotoxicity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL10739 GPL20301
20 Samples
Download data: CEL
Series
Accession:
GSE89411
ID:
200089411
10.

High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity using Human Induced Pluripotent Stem Cells

(Submitter supplied) Tyrosine kinase inhibitors (TKIs), despite efficacy as anti-cancer therapies, are associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We have utilized patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healthy individuals and 2 patients receiving cancer treatment, to screen FDA-approved TKIs for cardiotoxicities by measuring alterations in cardiomyocyte viability, contractility, electrophysiology, calcium handling, and signaling. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
10 Samples
Download data: CEL
Series
Accession:
GSE89410
ID:
200089410
11.

Recipient and donor expression differences in children treated with HSCT

(Submitter supplied) Reconstitution of cell lines and occurrence of complications following hematopoietic stem cell transplantation (HSCT) are regulated by genome expression. Microarray technique allows for simultaneous assessment of expression of nearly all human genes. The objective of the study was to compare whole genome expression in children before and after HSCT. A total of 44 children treated with HSCT were enrolled in the study. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
71 Samples
Download data: CEL
Series
Accession:
GSE88852
ID:
200088852
12.

Feasibility of unbiased RNA profiling of colorectal tumors: a proof of principle.

(Submitter supplied) Liquid biopsy profile which can screen for early CRC. We aimed to depict the profile of early stage CRC as well as for advanced adenomas by combination of current molecular knowledge with microarray technology, using efficient circulating free RNA purification from blood and RNA amplification technologies. Circulating free RNA profile of plasma from colorectal cancer patients, advanced adenomas and healthy colonoscopia subjects.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
10 Samples
Download data: CEL, TXT, XLSX
Series
Accession:
GSE83353
ID:
200083353
13.

Primary human nasal cells extracted from current smokers treated with kaempferol

(Submitter supplied) We are investigating the mRNA expression profiles of human nasal cells from smokers treated with kaempferol We used microarrays to compare the global mRNA expression profiles upon response to kaempferol treatment
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
4 Samples
Download data: CEL
Series
Accession:
GSE30982
ID:
200030982
14.

The role of mRNA decay in p53-induced gene expression

(Submitter supplied) The p53 tumor suppressor is a DNA damage responsive sequence-specific transcriptional activator. The sustained activation of the p53 response is incompatible with cell growth and viability. To circumvent this issue, a variety of negative feedback loops exist to limit the duration of p53 activation. Despite our understanding of p53-regulation, very little is known about the effect of transient p53 activation on the long term expression of p53 target genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
6 Samples
Download data: CEL
Series
Accession:
GSE76575
ID:
200076575
15.

Potential biomarkers tah could help to determine the prognosis of azoospermia treatment

(Submitter supplied) We analyzed gene expression profiles of human testicular biopsies in men with idiopathic nonobstructive azoospermia who underwent therapy with hCG/rFSH. Using new generation oligonucleotide microarray platform GeneChip® Human Gene 1.0 ST, we identified genes which could be potential prognostic biomarkers of azoospermia treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6244 GPL10739
12 Samples
Download data: CEL
Series
Accession:
GSE51111
ID:
200051111
16.

Comparasion between MCF7-NIK overexpressing cells, MCF7-control cells and MCF7-NIK depleted cells

(Submitter supplied) Analysis of differentially expressed genes in MCF7 cancer cells transfected with an expression vector containing the ORF of NIK, a shRNA of NIK and a control shRNA. Transient transfections were performed in triplicates . We use micorarrays to elucidate the machanisms by which NIK regulates stem cells biology
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
9 Samples
Download data: CEL
Series
Accession:
GSE63382
ID:
200063382
17.

Multi-platform assessment of transcriptional profiling technologies utilizing a precise probe mapping methodology

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
7 related Platforms
70 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE66649
ID:
200066649
18.

Multi-platform assessment of transcriptional profiling technologies utilizing a precise probe mapping methodology (Affymetrix_Gene1.0) (exon analysis)

(Submitter supplied) We present a more extensive and yet precise assessment to elucidate differences and similarities in performance at numerous aspects including signal range, sensitivity to fold-change, and fidelity with TaqMan qRT-PCR. There were three levels of data examined: entire data sets, data derived from gene name annotation oriented subset of 15442 RefSeq genes, and data derived from transcript pattern defined subset of 7034 RefSeq genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6244 GPL10739
20 Samples
Download data: CEL, CHP
Series
Accession:
GSE66628
ID:
200066628
19.

Microarray study of human adrenal zona glomerulosa (ZG), zona fasciculata (ZF) and aldosterone-producing adenomas (APA)

(Submitter supplied) Learn about the transcriptome profiling of zona glomerulosa (ZG), zona fasciculata (ZF) and aldosterone-producing adenomas (APA) in human adrenals
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
55 Samples
Download data: CEL
Series
Accession:
GSE64957
ID:
200064957
20.

Gene and miRNA expression profiling of Human ES cell line (hESC) derived embryoid body (EB) treated with H3R17methylation inhibitor TBBD

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL19546 GPL10739
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE64274
ID:
200064274
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