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Items: 1 to 20 of 2308

1.

Effect of group III phospholipase A2 deletion on gene expression in bronchial epithelial cells in an antigen-induced asthma model.

(Submitter supplied) Asthma is a chronic inflammatory disease of the airways characterized by recurrent episodes of airway obstruction, hyperresponsiveness, remodeling, and eosinophilia. Phospholipase A2s (PLA2s), which release fatty acids and lysophospholipids from membrane phospholipids, have been implicated in exacerbating asthma by generating pro-asthmatic lipid mediators, but an understanding of the association between individual PLA2 subtypes and asthma is still incomplete. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE249135
ID:
200249135
2.

Effect of group III phospholipase A2 deletion in antigen-induced asthma modeled lung

(Submitter supplied) Asthma is a chronic inflammatory disease of the airways characterized by recurrent episodes of airway obstruction, hyperresponsiveness, remodeling, and eosinophilia. Phospholipase A2s (PLA2s), which release fatty acids and lysophospholipids from membrane phospholipids, have been implicated in exacerbating asthma by generating pro-asthmatic lipid mediators, but an understanding of the association between individual PLA2 subtypes and asthma is still incomplete. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE249134
ID:
200249134
3.

Differential gene expression in brain tissues of Pla2g2e-deficient and wild-type mice

(Submitter supplied) To investigate the gene expression in brain tissues of Pla2g2e-deficient and wild-type mice, we performed gene expression profiling analysis using data obtained from Microarray of brain tissues collected from neuron-specific Pla2g2e-deficient and wild-type mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
6 Samples
Download data: TXT, XLSX
Series
Accession:
GSE232174
ID:
200232174
4.

Differential gene expression in brain tissues of Pla2g2e-deficient and wild-type mice on day 3 after ischemic stroke onset

(Submitter supplied) To investigate the gene expression in brain tissues of Pla2g2e-deficient and wild-type mice on day 3 after ischemic stroke onset, we performed gene expression profiling analysis using data obtained from Microarray of brain tissues from Pla2g2e-deficient and wild-type mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
7 Samples
Download data: TXT
Series
Accession:
GSE230996
ID:
200230996
5.

Expression profile of primary murine astrocyte-enriched cultures (AEC) exposed to oxygen-glucose deprivation

(Submitter supplied) Microarray analysis was used to identify genes that fluctuated by oxygen-glucose deprivation of mouse astrocytes. Astrocyte-enriched cultures were generated from mixed glial cultures of mice and compared to control samples with 15 hours of oxygen-glucose deprivation. The results showed that 173 genes were upregulated with Fold change >10, P < 0.05. Both Nr4a1 and Nr4a3, which is an orphan nuclear receptor subfamily and known as an immediate early gene, were upregulated.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE224577
ID:
200224577
6.

Molecular and Physiological Functions of PACAP in Sweat Secretion

(Submitter supplied) Sweat has a critical role in human body, including thermoregulation and maintenance of skin environment and health. Hyperhidrosis and anhidrosis are caused by abnormalities in sweat secretion resulting in severe skin conditions (pruritus and erythema). Bioactive peptide, pituitary adenylate cyclase-activating polypeptide (PACAP) was isolated and identified to activate adenylate cyclase in pituitary cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
8 Samples
Download data: TXT
Series
Accession:
GSE223124
ID:
200223124
7.

Gene expressional changes in control or adult reprogramming cardiomyocytes

(Submitter supplied) To investigate gene expressional changes in adult control or early reprogramming cardiomyocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT, XLS
Series
Accession:
GSE169035
ID:
200169035
8.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
10 Samples
Download data: TXT
Series
Accession:
GSE217139
ID:
200217139
9.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups III

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE217137
ID:
200217137
10.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups II

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE217136
ID:
200217136
11.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups I

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE217135
ID:
200217135
12.

Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

(Submitter supplied) A greater understanding of the glucose homeostasis mediated by glucagon-like peptide-1 (GLP-1) will facilitate the development of novel glucose-lowering treatments. Here we show that improved glucose metabolism in hypothyroid mice after treatment of T3, the active form of thyroid hormone (TH), is accompanied with increased GLP-1 production and insulin secretion. Treatment of a GLP-1 receptor antagonist is able to attenuate the observed T3 effect on insulin and glucose levels, suggesting that GLP-1 is critically involved in the regulation of glucose homeostasis by T3. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE184055
ID:
200184055
13.

Transcriptome profiling of murine overexpression of p65/RelA mutants III

(Submitter supplied) Effect of overexpression of murine p65/RelA and D361 mutant and resulting fragments in DA1-3B Bcr-Abl+ murine cell lines
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
17 Samples
Download data: TXT
Series
Accession:
GSE135137
ID:
200135137
14.

Transcriptome profiling of murine overexpression of p65/RelA mutants II

(Submitter supplied) Effect of overexpression of murine p65/RelA and D361 mutant and resulting fragments in B16 Bcr-Abl+ murine cell lines
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
20 Samples
Download data: TXT
Series
Accession:
GSE135136
ID:
200135136
15.

Trancriptome profiling of murine overexpression of p65/RelA mutants

(Submitter supplied) Effect of overexpression of murine p65/RelA and D361 mutant and resulting fragments in DA1-3B Bcr-Abl+ murine cell lines
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
24 Samples
Download data: TXT
Series
Accession:
GSE98437
ID:
200098437
16.

Metformin in the ileum

(Submitter supplied) C57BL/6J male mice were treated with or without metformin
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE201039
ID:
200201039
17.

Group IVE Cytosolic Phospholipase A2 Limits Psoriatic Inflammation by Mobilizing the Anti-inflammatory Lipid N-Acylethanolamine

(Submitter supplied) Psoriasis is an inflammatory disorder characterized by keratinocyte hyper-proliferation and Th17-type immune responses. However, the roles of bioactive lipids and the regulation of their biosynthesis in this chronic skin disease are not fully understood. Herein, we show that group IVE cytosolic phospholipase A2 (cPLA2epsilon/PLA2G4E) plays a counterregulatory role against psoriatic inflammation by producing the non-canonical anti-inflammatory lipid N-acylethanolamine (NAE). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE196431
ID:
200196431
18.

Gene expression profiles of ears infected with Staphylococcus aureus at ZT4

(Submitter supplied) We analysed the gene expression profiles after infection of Staphylococcus aureus at ZT4 in CXCL14-KO mice. The group of genes categolized as GO defense response (GO: 006952) were upregulated upon a response to Staphylococcus aureus infection. The expression of IL1b, Cxcl2, and Ccl3 were significantly suppressed in infected ear of Cxcl14-KO compared to that of WT.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE164899
ID:
200164899
19.

Chicory: cutting the effects and the effectors for a functional food

(Submitter supplied) Whole chicory flour (Chic) and three compounds of chicory roots: fructose (Fru), chlorogenic acids (CGA) and sesquiterpene lactones (STL) were separately analyzed for their health effects in mice. A whole transcriptomic analysis was conducted using Agilent DNA microarrays to investigate their nutrigenomic effects.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
48 Samples
Download data: GPR, XLSX
Series
Accession:
GSE190056
ID:
200190056
20.

Effect of group IIA phospholipase A2 deletion on gene expression in the small intestine

(Submitter supplied) Besides promoting inflammation by mobilizing lipid mediators, secreted phospholipase A2 group IIA (sPLA2-IIA) prevents bacterial infection by degrading bacterial membranes. Here we show that despite the restricted intestinal expression of sPLA2-IIA in BALB/c mice, its genetic deletion leads to amelioration of cancer and exacerbation of psoriasis in distal skin. Intestinal expression of sPLA2-IIA is reduced after antibiotics treatment or under germ-free conditions, suggesting its upregulation by gut microbiota. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE182283
ID:
200182283
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