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| To identify common variants underlying alcohol-dependence, probands were ascertained through alcohol treatment programs and evaluated at 7 centers in the United States: as part of the Collaborative Study on the Genetics of Alcoholism ( Edenberg, 2002 ; Foroud et al., 2000 ; Reich et al., 1998 ). Probands and their relatives were administered a validated poly-diagnostic instrument, the Semi- Structured Assessment for the Genetics of Alcoholism (SSAGA)( Bucholz et al., 1994 ; Hesselbrock et al., 1999 ), which allows assessment of alcohol dependence under several diagnostic systems. Genotyping was performed by the Center for Inherited Disease Research ( CIDR ). DNA sources included blood (n = 1453) and lymphoblastoid cell lines (LCL, n = 492). |
| To identify common variants underlying alcohol-dependence, probands were ascertained through alcohol treatment programs and evaluated at 7 centers in the United States: as part of the Collaborative Study on the Genetics of Alcoholism ( Edenberg, 2002 ; Foroud et al., 2000 ; Reich et al., 1998 ). Probands and their relatives were administered a validated poly-diagnostic instrument, the Semi- Structured Assessment for the Genetics of Alcoholism (SSAGA)( Bucholz et al., 1994 ; Hesselbrock et al., 1999 ), which allows assessment of alcohol dependence under several diagnostic systems. Genotyping was performed by the Center for Inherited Disease Research ( CIDR ). DNA sources included blood (n = 1453) and lymphoblastoid cell lines (LCL, n = 492). |
| To identify common variants underlying alcohol-dependence, probands were ascertained through alcohol treatment programs and evaluated at 7 centers in the United States: as part of the Collaborative Study on the Genetics of Alcoholism ( Edenberg, 2002 ; Foroud et al., 2000 ; Reich et al., 1998 ). Probands and their relatives were administered a validated poly-diagnostic instrument, the Semi- Structured Assessment for the Genetics of Alcoholism (SSAGA)( Bucholz et al., 1994 ; Hesselbrock et al., 1999 ), which allows assessment of alcohol dependence under several diagnostic systems. Genotyping was performed by the Center for Inherited Disease Research ( CIDR ). DNA sources included blood (n = 1453) and lymphoblastoid cell lines (LCL, n = 492). |