| This analysis of transmission distortion in the Framingham Heart Study (FHS) was performed by Wynn K. Meyer. A detailed description of the methods and results may be found in: Meyer W.K., Arbeithuber B., Ober C., Ebner T., et al., 2012 Evaluating the Evidence for Transmission Distortion in Human Pedigrees. Genetics 191: 215-232. This analysis contained 4,395 individuals in 2,362 trios and was based on all maternal transmissions. Genotyping was conducted by FHS using the GeneChip Human Mapping 500K Array Set (Affymetrix). |
| The study of low frequency and potentially functional variants may refine and expand our understanding of the genetic determinants of circulating metabolite levels. To that end, we analyzed the association between 217 plasma metabolites and exome variants captured on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study (FHS). The Framingham Heart Study (FHS) Offspring cohort is a prospective, observational, community-based cohort. The participants are primarily Caucasian. These children of the initial FHS participants and their spouses were recruited in 1971 and have been followed with serial examinations. A total of 2,076 Offspring participants who attended the fifth examination (1991-1995) and underwent metabolite profiling and exome array genotyping were included in this analysis. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Offspring 6 SHQ data excluding 5 AM to 6 PM bedtimes and wd-we bedtime diff >2h\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"None\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Hip geometry (NN BucklingRatio, MV adj, Women)\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"Cohort specific Ranked residuals. Linear regression, adj for age, age2, HGT & BMI\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Log (TG-HDL Ratio) Offspring Exam 3, TG value imputed if subject on Chol-lowering Rx\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \" age, age2, separately by gender\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Residual Log HOMA-IR exam 7 offspring\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"age,age^2, separately by sex\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Systolic - diastolic BP avg(MD1,MD2), imputed for Rx cycle 1 \". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"Age, sex, BMI\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"NMR HDL Large Offspring Exam 4, observation excluded if subject on Chol-lowering Rx or TG greater than 400\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \" age, age2, bmi, alc, smk, meno, HRT separately by gender\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for linkage between genotypes and phenotypic trait as \"percent predicted, most recent exam with acceptable data\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"residuals after 2-stage modeling: 1) predicted trait based on age, age2, height2; 2) adjust percent predicted for former smoking, current smoking, packyears, BMI\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Ranked residual BMI Exam 24 cohort exam 6 offspring in males\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"cohcov:age24,agesq24,smoke24,meno24; offcov:age6,agesq6,smoke6,meno6\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Log transformed IsoCr. Age & sex\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates ITBiomarkers. Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Age, sex, smoking, SBP, DBP, HTN Rx, BMI, waist, TC/HDL, TG, lipid med, glucose, DM, ASA, HRT, CVD\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates ITBiomarkers. Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for linkage between genotypes and phenotypic trait as \"Age cubic (a1 a2 a3), sex, BMI, CVD, Smoker, HRx, SBP, DBP, conj_est, ETOH, TG, DM T.Chol HDLC\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates ITBiomarkers. Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for linkage between genotypes and phenotypic trait as \"Ranked Residual Log Fasting Insulin exam 5 offspring\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"age,age^2, separately by sex\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Sex-specific adjusted for generation Logistic regression\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"MMSE score at age 65\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Residual BMI Exam 24 cohort exam 6 offspring in males\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"cohcov:age24,agesq24,smoke24,meno24; offcov:age6,agesq6,smoke6,meno6\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Hip geometry (Neck CSMI, MV adj, Men)\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"Cohort specific residuals. Linear regression, adj for age, age2, HGT & BMI\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Residual Fasting Log Insulin exam 7 offspring\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"age,age^2, separately by sex\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for linkage between genotypes and phenotypic trait as \"Residual mean HGT across 7 exams in males\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates \"coh and off cov:meanage,meanagsq,meansmok,meanmeno where mean=mean(of all available, max=7)\". Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |
| This analysis scans human genome for association between genotypes and phenotypic trait as \"Age, sex, SBP, DBP, BMI, waist, total/HDL, current smoke, glucose, TG, DM, HTN Rx, lipid lowering Rx, HRT, asthma Rx, alcohol use (ounces/month), prevalent CVD. (some participants measured 6 some 7) Covariates from exam Vit. Ascertained\". It is a part of the National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study project and conducted by researchers from NHLBI and Boston University School of Medicine. This genetic epidemiological research applies population-based longitudinal cohort design and the trait is adjusted for confounding covariates ITBiomarkers. Genotyping was performed by Dr. Norman Gerry in the Genetics and Genomics Department at Boston University using GeneChip Human Mapping 100K microarrays from Affymetrix. |