Literature
PubMed
PubMed® comprises more than 37 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
Featured Bookshelf titles
Drug Therapy for Early Rheumatoid Arthritis
A Systematic Review Update
Literature databases
Books and reports
Ontology used for PubMed indexing
Books, journals and more in the NLM Collections
Scientific and medical abstracts/citations
Full-text journal articles
Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Collected information about gene loci
Functional genomics studies
Gene expression and molecular abundance profiles
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved protein domains
Protein sequences grouped by identity
Protein sequences
Models representing homologous proteins with a common function
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
Search nucleotide sequence databases
Search protein sequence databases
Search protein databases using a translated nucleotide query
Search translated nucleotide databases using a protein query
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Genome assembly information
Museum, herbaria, and other biorepository collections
Biological projects providing data to NCBI
Descriptions of biological source materials
Genome sequencing projects by organism
DNA and RNA sequences
High-throughput sequence reads
Taxonomic classification and nomenclature
Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
Privately and publicly funded clinical studies conducted around the world
Human variations of clinical significance
Genotype/phenotype interaction studies
Short genetic variations
Genome structural variation studies
Genetic testing registry
Medical genetics literature and links
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
Bioactivity screening studies
Chemical information with structures, information and links
Molecular pathways with links to genes, proteins and chemicals
Deposited substance and chemical information
News
Research news
Study Reveals a Cell-Eat-Cell World
From normal vertebrate development to tumor cell cannibalism, cell-in-cell events occur in many different contexts across the tree of life
Researchers Bioengin-Ear Tissue Scaffolds to Human Scale
A new approach to sculpting human-like ears merges 3D printing, xenografts, and tissue engineering.
Do cats experience grief? New research suggests they might
Researchers from Oakland University surveyed hundreds of cat caregivers and found that cats exhibited behaviors associated with grief after a fellow cat or dog in the household died.
Recent blog posts
New API Key System Coming Soon to NCBI Datasets
Increased flexibility, efficiency, and reliability Do you use the NCBI Datasets command-line tools or API? As of January 2025, you will have the option to use an API key to increase your rate of access. This update will provide you more flexibility and efficiency, while still maintaining robust access for everyone. Note that these changes … Continue reading New API Key System Coming Soon to NCBI Datasets
NIH’s CARE for Health Primary Care Research Network: Connecting the Lab, the Clinic, and the Community
Since I became NIH Director last year, one key principle has guided my vision and approach: Our work is not finished when we deliver scientific discoveries; our work is finished when all people are living long and healthy lives. But unfortunately, we’re seeing some alarming trends in the health of the U.S. population. It’s a bit of a puzzle. On one hand, significant advances in biomedical research over the last several decades have led to lifesaving interventions for a range of diseases and conditions. At the same time, the overall health of the people in this country appears to be stalled and even getting worse.
AI Model Takes New Approach to Performing Diagnostic Tasks in Multiple Cancer Types
In recent years, medical researchers have been looking for ways to use artificial intelligence (AI) technology for diagnosing cancer. So far, most AI models have been developed to perform specific tasks in cancer diagnosis, such as detecting cancer presence or predicting a tumor’s genetic profile in certain cancer types. But what if an AI system could be more flexible, like a large language model such as ChatGPT, performing a variety of diagnostic tasks across multiple cancer types? As reported in the journal Nature, researchers have developed an AI system that can perform a wide range of cancer evaluation tasks and outperforms current AI methods in tasks like cancer cell detection and tumor origin identification. It was tested on 19 cancer types, leading the researchers to refer to it as “ChatGPT-like” in its flexibility. According to the research team, whose work is supported in part by NIH, this is also the first AI model based on analyzing slide images to not only accurately predict if a cancer is likely to respond to treatment, but also to validate these predictions across multiple patient groups around the world.