nucleotide-binding domain (NBD) of ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and similar proteins
NTPDase1 (EC 3.6.1.5), also called Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Ecto-apyrase, or lymphoid cell activation antigen CD39, is a known E-type apyrase that could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission in the nervous system. It could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. NTPDase1 hydrolyzes ATP and ADP equally well. In addition, NTPDase1 can also hydrolyze ATP to AMP without the release of ADP.
Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:E
Evidence:
Comment:The carboxylate group of Glu serves as a catalytic base and activates a water molecule, which is well positioned for nucleophilic attack on the terminal phosphate.
Jiyao W et al.(2023). "The conserved domain database in 2023.",