1G74,2ANS,2QM9,1TOU,1G7N,5BVQ,5HZ8,5HZ6


Conserved Protein Domain Family
FABP4

?
cd19467: FABP4 
fatty acid binding protein 4
FABP4 (also known as A-FABP, adipocyte fatty acid binding protein, aP2) is highly expressed in macrophages and in adipocytes where it regulates fatty acid storage and lipolysis and is an important mediator of inflammation. It binds long chain fatty acids, retinoic acid and eicosanoids. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.
Statistics
?
PSSM-Id: 381242
Aligned: 9 rows
Threshold Bit Score: 244.149
Created: 13-May-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding cavity [chemical binding site]
Evidence:
  • Comment:ligand is bound within the beta-barrel in a central internal water-filled cavity lined with polar and hydrophobic amino acids
  • Comment:based on FABP3 and other cytosolic fatty-acid binding protein family members with structure
  • Structure:1G74; Mus musculus adipocyte lipid-binding protein with bound oleic acid, contacts 4A
  • Citation:PMID 7683727

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1        #           #  ##  # #   ##  #  # # # #      # # ### ## # # #       ##### #  
1G74_A      1 CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEETVDGRKV 80  house mouse
2ANS_B      1 CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKV 80  house mouse
2QM9_A     25 CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKV 104 house mouse
1TOU_A      1 CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKV 80  human
NP_989621   2 CDQFVGTWKLLSSENFEDYMKELGVGFATRKMAGVAKPNLTISINGDVITIRSESTFKNTEISFKLGEEFDETTADDRKT 81  chicken
1G7N_A      1 CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEETVDGRKV 80  house mouse
5BVQ_A      2 CDQFVGTWKFLSSENFEDYMKELGVGFATRKMAGVAKPNVTISINGDVITIKTESTFKNTEVSFRLGEEFDETTADDRKT 81  Pygoscelis papua
5HZ8_A      5 CDAFVGTWKLVSSENFDDYMKELGVGFATRKVAGMAKPNTIISVNGDVITLKTESTFKNTEISFILGQEFDEVTADDRKV 84  human
5HZ6_A      1 AGAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKV 80  human
Feature 1               # #          # #      # # #        # #  
1G74_A     81 KSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYER 130 house mouse
2ANS_B     81 KSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYER 130 house mouse
2QM9_A    105 KSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYER 154 house mouse
1TOU_A     81 KSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYER 130 human
NP_989621  82 KNVITLDSGTLKQVQKWDGKETVIKRKVVDGNLLVECTMNNVTSKRVYER 131 chicken
1G7N_A     81 KSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYER 130 house mouse
5BVQ_A     82 KNVITLDNGILNQVQKWDGKETVIKRKVMDGNLVVECTMNTVTSKRVYER 131 Pygoscelis papua
5HZ8_A     85 KSTITLDGGVLVHVQKWDGKSTTLKRKREDDKLVLELVMKGVTCTRVYER 134 human
5HZ6_A     81 KSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYER 130 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap