2WDP,2J30,3E4C,1M72,1I4O,3H11,3H11,1NW9


Conserved Protein Domain Family
CASc

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smart00115: CASc 
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Caspase, interleukin-1 beta converting enzyme (ICE) homologues
Cysteine aspartases that mediate programmed cell death (apoptosis). Caspases are synthesised as zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologues.
Statistics
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PSSM-Id: 214521
Aligned: 38 rows
Threshold Bit Score: 259.093
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2WDP_A     37 YKMDHRRRGIALIFNHERF----------FWhl-----------tLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEE 95  human
NP_116759 276 YRMNRNHRGLCVIVNNHSF----------TS--------------LKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVE 331 human
AAB46730  276 YRMNRNHRGLCVIVNNHSF----------TS--------------LKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVE 331 human
AAL87628  285 YQMKSKPRGYCLIINNHNFakarekvpklHS--------------IRDRNGTHLDAGALTTTFEELHFEIKPHDDCT-VE 349 human
BAF84769  153 YILSMEPCGHCLIINNVNF----------CRes-----------gLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKK 211 human
AAC15825  244 YKMKSKPLGICLIIDCIGN----------E-------------------------TELLRDTFTSLGYEVQKFLHLSMHG 288 human
AAP36630  244 YKMKSKPLGICLIIDCIGN----------E-------------------------TELLRDTFTSLGYEVQKFLHLSMHG 288 synthetic construct
AAC31214  123 LKLTRENAGIALIINQQKF----------HRnvsrdnmkflspdpLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMG 192 fruit fly
3H11_B     10 YQMKSKPRGYCLIINNHNFakarekvpklHS--------------IRDRNGTHLDAGALTTTFEELHFEIKPHDDCT-VE 74  human
3H11_A     36 YKMKSKPLGICLIIDCIGN----------E-------------------------TELLRDTFTSLGYEVQKFLHLSMHG 80  human
2WDP_A     96 LLLKIHEVSTv-ShadADCFVCVFLSHG-------EGNHIYAYD---AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAC- 163 human
NP_116759 332 MEMVLQKQKCnpAhadGDCFVFCILTHG-------RFGAVYSSDe--ALIPIREIMSHFTALQCPRLAEKPKLFFIQAC- 401 human
AAB46730  332 MEMVLQKQKCnpAhadGDCFVFCILTHG-------RFGAVYSSDe--ALIPIREIMSHFTALQCPRLAEKPKLFFIQAC- 401 human
AAL87628  350 QIYEILKIYQlmDhsnMDCFICCILSHG-------DKGIIYGTDg--QEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC- 419 human
BAF84769  212 MVLALLELAr-qDhgaLDCCVVVILSHGcqashlqFPGAVYGTDg--CPVSVEKIVNIFNGTSCPSLGGKPKLFFIQAC- 287 human
AAC15825  289 ISQILGQFACmpEhrdYDSFVCVLVSRG-------GSQSVYGVDqthSGLPLHHIRRMFMGESCPYLAGKPKMFFIQNY- 360 human
AAP36630  289 ISQILGQFACmpEhrdYDSFVCVLVSRG-------GSQSVYGVDqthSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYv 361 synthetic construct
AAC31214  193 IIERIRSACDrs--lvRDSLVVFILSHG-------FEEAVYASNs--IAMKITDIEDLL--CSYDTLYYKPKLLIIQAC- 258 fruit fly
3H11_B     75 QIYEILKIYQlmDhsnMDCFICCILSHG-------DKGIIYGTDg--QEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC- 144 human
3H11_A     81 ISQILGQFACmpEhrdYDSFVCVLVSRG-------GSQSVYGVDqthSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYv 153 human
2WDP_A    164 --RGNQHDVPVIPLD-VVD--NQtekldtnitEV------------------DAASVY-T--LPAGADFLMCYSVAEGYY 217 human
NP_116759 402 --QGEEIQPSVSIEA-DAL--NP---------EQ------------------APTSLQdS--IPAEADFLLGLATVPGYV 447 human
AAB46730  402 --QGEEIQPSVSIEA-DAL--NP---------EQ------------------APTSLQdS--IPAEADFLLGLATVPGYV 447 human
AAL87628  420 --QGDNYQKGIPVET-DSE--EQpy------lEM------------------DLSSPQ-TryIPDEADFLLGMATVNNCV 469 human
BAF84769  288 --GGEQKDHGFEVAS-TSP--EDe-------sPGsnpepdatpfqeglrtfdQLDAIS-S--LPTPSDIFVSYSTFPGFV 352 human
AAC15825  361 --VVSE-GPAGDSSL-WRV--DGpamk-nvefRA------------------QKRGLC-T--VHREADFFWSLCTADMSL 412 human
AAP36630  362 vsEGQLEDSSLLEVD-GPAmkNVe-------fKA------------------QKRGLC-T--VHREADFFWSLCTADMSL 412 synthetic construct
AAC31214  259 --QEKLVHKKKPNEL-FR----------------------------------IDVTTV-S--PDQHIDMLRAMSTVNGYA 298 fruit fly
3H11_B    145 --QGDNYQKGIPVETaSEE--QPy-------lEM------------------ALSSPQ-TryIPDEADFLLGMATVNNCV 194 human
3H11_A    154 vsEGQLENSSLLEVD-GPAmkNVe-------fKA------------------QKRGLC-T--VHREADFFWSLCTADMSL 204 human
2WDP_A    218 SHRETVNGSWYIQDLCEMLGK-Y-GSSLEFTELLTLVN-RKVSqrrvdfCKDPSAIGKKQVPCFASm-LtKKLHFF 289 human
NP_116759 448 SFRHVEEGSWYIQSLCNHLKKlV-PRHEDILSILTAVN-DDVS------RRVDKQGTKKQMPQPAFt-LrKKLVFP 514 human
AAB46730  448 SFRHVEEGSWYIQSLCNHLKKlV-PRMLKFLEKTMEIRgRKRT------VWGAKQISATSLPTAISaqTpRPPMRR 516 human
AAL87628  470 SYRNPAEGTWYIQSLCQSLRE-RcPRGDDILTILTEVN-YEVS------NKDDKKNMGKQMPQPTFt-LrKKLVFP 536 human
BAF84769  353 SWRDPKSGSWYVETLDDIFEQ-W-AHSEDLQSLLLRVA-NAVS------VKGIY----KQMPGCFNf-LrKKLFFk 414 human
AAC15825  413 LEQSHSSPSLYLQCLSQKLRQ---ERKRPLLDLHIELN-GYMY------DWNSRVSAKEKYYVWLQhtLrKKLILS 478 human
AAP36630  413 LEQSHSSPSLYLQCLSQKLRQ---ERKRPLLDLHIELN-GYMY------DWNSRVSAKEKYYVWLQhtLrKKLILS 478 synthetic construct
AAC31214  299 ALRHTQTGSWFIGSLCDAIDR-R-SASEHIADILTIVT-NEVS------KKRGS-NDESMVPNVKSt-FrQHVYFP 363 fruit fly
3H11_B    195 SYRNPAEGTWYIQSLCQSLRE-RcPRGDDILTILTEVN-YEVS------NKDDKKNMGKQMPQPTFt-LrKKLVFP 261 human
3H11_A    205 LEQSHSSPSLYLQCLSQKLRQ---ERKRPLLDLHIELN-GYMY------DWNSRVSAKEKYYVWLQhtLrKKLILS 270 human
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