2C6Y,1JXS


Conserved Protein Domain Family
FH_FOXK2
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cd20055: FH_FOXK2 
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Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins
FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410829
Aligned: 7 rows
Threshold Bit Score: 194.65
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2C6Y; Homo sapiens FOXK2 binds DNA through its Forkhead domain, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  ###                 ##  #              #   ## ##  ##     #       # ### #   
2C6Y_A        14 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 93  human
1JXS_A         1 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 80  human
Q7ZX03       217 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 296 African clawed ...
Q01167       256 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335 human
XP_006009909 217 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 296 coelacanth
NP_001184186 202 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVARSQEEPGKGSFWRID 281 zebrafish
RMB92191      33 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 112 Hirundo rustica...

Feature 1                      #  #
2C6Y_A        94 PasESKLIEQAFRKRRPR 111 human
1JXS_A        81 PasESKLIEQAFRKRRPR 98  human
Q7ZX03       297 PasESKLVEQAFRKRRPR 314 African clawed frog
Q01167       336 PasESKLIEQAFRKRRPR 353 human
XP_006009909 297 PasESKLIEQAFRKRRPR 314 coelacanth
NP_001184186 282 PssEGKLMDQAFRKRRPR 299 zebrafish
RMB92191     113 PasESKLIEQAFRKRRPR 130 Hirundo rustica rustica

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