2C1W


Conserved Protein Domain Family
XendoU

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pfam09412: XendoU 
Endoribonuclease XendoU
This is a family of endoribonucleases involved in RNA biosynthesis which has been named XendoU in Xenopus laevis. XendoU is a U-specific metal dependent enzyme that produces products with a 2'-3' cyclic phosphate termini.
Statistics
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PSSM-Id: 462792
Aligned: 82 rows
Threshold Bit Score: 214.733
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2C1W_A         11 ELSKLFNELWDADQNRm------------KSGKDY-RISLQGKAGyvpagSNQARd---------------------sAS 56  
Q9GYM9        309 ALQTLVDKMWGDDQDR-------------PSATQV-TMNWGEHIS-----GKTGT-----------------------KG 346  Caenorhabditi...
PDM80296      509 ELQDLVNNMRAQDDDK-------------PMSSQY-LLTWGDKLG-----KNPKP-----------------------SG 546 
KAF8359470    737 EFQTLVDNMRAQDADK-------------PTSSQY-KLNWGTKLG-----SNPKP-----------------------SG 774 
EFC44713        8 FSATLMDEIWQADENRl------------TP---V-KIKPQGPIG-----GEYICvvcgmdrkrsnpnftlfklyqydAT 66  
XP_002070081   55 DVLSLSKSLYA-EESA--------------SSPYIyKLNLQGRTT-----SGAHDd---------------------kAP 93  
XP_002053222   58 DVLTLSQALFT-EETA--------------SSPYLyNVNLQVKTR-----AGAHDd---------------------rAP 96  
EDW41986       56 DVLTLSKNLYA-EETE--------------VSPYLyKVNIQGKTT-----SGAHDd---------------------rAP 94  
XP_003109335   29 ELLAMAKKLRQVDTNR-------------ARPDQI-KLNYQKHTV-----TRDDSd---------------------aAP 68  
Q7NF33         36 QTMTIYQKLWDSDENRftvtqrneagewaDPQAEV-FLDAQVRAS-----GKRSLd---------------------lAA 88   Gloeobacter v...
2C1W_A         57 FPLFQFVDEEKLks-----rkTFATFISLLDN--YEMDTGVAE--VVTPE------EIAENNNFLDAILETKVMKMAHDY 121 
Q9GYM9        347 ANLFTTVDESIF---------TKKQYADLITT--YTQDLFTAD--VCKAEpamggfRKQYLQGVFNTFTATPMFASAFAY 413  Caenorhabditi...
PDM80296      547 KDLVSNVDESLFdt------pVYAALKKVYDNgiLVPDVCTTEtdYNSGF------KRSILQSLLDTWSTTKPFQLMHDF 614 
KAF8359470    775 KDLMSNVAESLFsk------pVYAALKKAYDNniFNADVCVSE--SDYQSg----fKQSIIQSLLDTWSSTKPFTLMHDY 842 
EFC44713       67 KHVYVQVKNSEFlqsnskqakNYKLISRLFDN--YSLDQHSRE--VNTEE------ERKEVEQFLESIVQTKCMRILGQK 136 
XP_002070081   94 KSLFE-LHQDLLsrd---ansTTALLLRLFNN--YELDVAVAE--HVTPE------HKEEQHEFLRAIMQTRIMKLAMRY 159 
XP_002053222   97 HPLFE-LHYDLLtrd---ansTTALLMRLFNN--YELDVAVPD--QITAE------HEQEQLDFLRAVMNTRVMKISMRF 162 
EDW41986       95 RNLFE-LHQDLLard---ansTTALLMRLFDN--YELDVAVQE--HPTPE------HIQEQHDFLRAVMGTRVMKLTMRY 160 
XP_003109335   69 AKLFSKVDTSLFrk------pSYELYLNLMDN--FNRQTGIIEprVTQSE------EKNEVGKFLDYVLETNPMKELYNW 134 
Q7NF33         89 GPLFAKVEEAKLrk------pTYAAFIALLDN--YATTARVAE--SYDSG------EEEEIQDYLEVIRETVPVRLAREY 152  Gloeobacter v...
2C1W_A        122 LV-RKNQa-KPTR-NDFK-VQLYNIWFQLYSRAPGSr--PDSCGFEHVFVGEsKR----------GQEMMGLHNWVQFYL 185 
Q9GYM9        414 LQ-SINYkeTSNL-TNFKtKVLWPLWFGTYTRCKGP---LGSSGWEHVFSGE-IK----------SNEVDGQHDWVRYYT 477  Caenorhabditi...
PDM80296      615 LV-GRGKv-PADL-TQFK-QFLTTFWFGTYTRCSDKk-tIGSSGFEHVFSGE-WK----------GTTIDGHHNWMKYYI 678 
KAF8359470    843 LV-KKGKv-DSDM-TKFK-KFLTTYWFGTYSRCSNNkktIGSSGFEHVFSGE-WK----------DGTIDGHHNWMKYYL 907 
EFC44713      137 YM-------KLSTpTELK-VKLREIWFKQYNLHNYK----DLSGFEHLVVGE-KN----------GDKVSGYHYWFKYLL 193 
XP_002070081  160 LM-HKGIv-SSDY-DEQF-KLLQDLWFTPYSRGGGI---VGSSSFEHVFMAE-IR----------NQNVLGLHNWLYFAE 221 
XP_002053222  163 LA-KRGIv-SSDY-DEQL-KLLQELWFTPYSRGKGI---VGSSSFEHVFMAE-LR----------DQKVLGMHNWLYFAE 224 
EDW41986      161 LV-HKDIv-SVEY-DDQL-RLLQELWFTPYSRGRGI---VGSSSFEHVFMAE-IR----------DQKVLGLHNWLYFAD 222 
XP_003109335  135 FK-AKGHsiAANP-TAFR-FWIGQLWFSHYSRALGR---PDTSGFEHVFIGE-AK----------NGEISGMHNWVRFYA 197 
Q7NF33        153 INgDLGR--NLSE-VQFM-AALRRIWFELFTNYFQGksqEYCSGFEHVFVGE-AKydtrfggaenLGEISGYHNWIKFFL 227  Gloeobacter v...
2C1W_A        186 QEK--RK-NIDYKGYVarqnksrpDEDDQV-LNLQFNWK-----------EMvKPVGSSFIGVSPEFEFALYTIVFLASQ 250 
Q9GYM9        478 EQK--AD-KMVYDGYY--------THDENLiGTFQYKWN-----------GAlKPKGGFFTGTSPAFDFSILSVCALAHG 535  Caenorhabditi...
PDM80296      679 NQK--AG-EIKYYGYY--------SEQGQLtGTYEYDWA-----------GLnKKTGGMLFGTSPVFDFSLFTACSLTHT 736 
KAF8359470    908 DQK--AK-KIAYYGYY--------STDGQLtGTFEYDWS-----------DHhKDKGGMLFGTSPVFDFSLYTACSMVHS 965 
EFC44713      194 DDStdNHtGQDVISFAgrl--dneSTPDYV--CVRFKQDedvdgdgqsdnQLfKSCGSFFVGISPECLLALSTLAYLESL 269 
XP_002070081  222 QEQ--QG-RIDYKGWLkhl--emgKPNQMV-LNERHTFY-----------GItKPSNSFLVGTSPELGMSLYTVCFLTTE 284 
XP_002053222  225 QEQ--QG-HVNYKGWLnrf--dtgRHNQFA-LAFRMSFF-----------GIeKSFNGFLVGTSPELEMSLYTVCFLATA 287 
EDW41986      223 QEQ--RG-NVDYKGWLnhk--emgKHNQMV-LSVRYTFH-----------NInKPVNGFFVGTSPELDLALYTACFLATA 285 
XP_003109335  198 LENnrTE-NFDYKGFT--------VKRFNImAALKFTWD-----------GLlKRAGSILIGTSPEFDMALYTMCFLSRR 257 
Q7NF33        228 DEK--FG-RVNFLGYKydlrgeetPDNPNV-VTLQMEWElknmggetlarLF-KKKGGFFVGTSPECEIAMGTVAFYESE 302  Gloeobacter v...
2C1W_A        251 EK-----MSRevVRLEEYELQIVVNRH-------GRYIGTAYP 281 
Q9GYM9        536 NGg----NCH--FKVTNYPITVTSYLQdcg-dgsGTCLATAYP 571  Caenorhabditis elegans
PDM80296      737 GEa----GCK--FSIDDVPLAVTSYTQdca--ggGLCLSTSYP 771 
KAF8359470    966 GSd----GCR--FSIDGYQLAVTSYTQdca--ggGLCLSTAYP 1000
EFC44713      270 QPsgkknLSD--VKINGNRYVINVFNE-------GGYPRSIYP 303 
XP_002070081  285 KQe----PCP--IQLGHARLSIVSHVWew---kgKRLIASAYP 318 
XP_002053222  288 EKe----PCE--IQLGTAKLSIVSHVWdw---kgKRLIASTYV 321 
EDW41986      286 EEe----PCH--IQLGHASATIVSHGWkw---ngMRLIGTAYP 319 
XP_003109335  258 GRe----TCD--VELDGCPLQITSFEImq---qnKVYIGSIYP 291 
Q7NF33        303 QGllrqeKRQ--TTINGARYNLVLYRSttpqgsrGDFIRSFYP 343  Gloeobacter violaceus
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