1QRV,1HMA,3NM9,1WXL,1E7J,5VWE


Conserved Protein Domain Family
HMG-box_SSRP1-like

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cd21994: HMG-box_SSRP1-like 
Click on image for an interactive view with Cn3D
high mobility group (HMG)-box found in structure-specific recognition protein 1 (SSRP1) and similar proteins
SSRP1, also called FACT complex subunit SSRP1, chromatin-specific transcription elongation factor 80 kDa subunit, facilitates chromatin transcription complex 80 kDa subunit (FACT 80 kDa subunit or FACTp80), facilitates chromatin transcription complex subunit SSRP1, recombination signal sequence recognition protein 1, or T160, is a factor that facilitates transcript elongation through nucleosomes. It is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication, and DNA repair.
Statistics
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PSSM-Id: 438810
Aligned: 36 rows
Threshold Bit Score: 66.1675
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1QRV; Drosophila melanogaster HMG-D binds DNA, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         # ## ##  ##  #   #       ##  ##  #  ##                    #   #   #
1QRV_A          6 RPLSAYMLWLNSARESIKRENPgikVTEVAKRGGELWRAMK--DKSEWEAKAAKAKDDYDRAVKEFE 70   fruit fly
XP_028968499 1480 RPTTPYFLWMLRNVDRIKADNPglsVVEIAKICGEEWNELS--DQEKWVKKNKKAREEWRKKHGPYK 1544 western predatory mite
XP_028968499   19 RPTSAYFYWMLQHRQRLIEENPglsVTELAEVAGETWRQLP--NKDRWIRLNKEAKAKWDKKHGRVA 83   western predatory mite
XP_002596583  549 KAMTAFMLWLNATRSELRKENPdasIGEIGKIAGEKWREMGpsDKEEWEQKAKEDKERYKAAMEEYQ 615  Florida lancelet
CBN79433      183 RARSAWMLFLADNREGVRKEHPglaVGPMQKILSEMWKALGeaEVARYAKLAAEDKERVKNELAAAG 249  Ectocarpus siliculosus
XP_004994950  579 KAKTAYALWSSSARSKLKEQHPdlsFGELSKKLGQAWQDLAdeDKAEWNEKAKEDRQRYLKEKKKFD 645  Salpingoeca rosetta
CDW83903      128 KSKSAYIAFIEKNIAQVKSDNPgleQAQIMKKTAEIWNSMDevQKAPYKQIASDDKQRQVNQIQAQN 194  Stylonychia lemnae
XP_026280910   40 RGKTAWVLYFSEHWPLLVKENPgisKSDIFKKLSDNWHKLDksVLEKYQQISEESKKKYQEEIEVYK 106  western flower thrips
CDW74022       60 KPMSAFFCYQQARRDALKKEAPelnHKDIIKRMSEEWKVLTdaDKQQYQAQSDRGREKYDKDMKAYK 126  Stylonychia lemnae
CDW82148      261 RPITGFQMYLRELREKLKKDNPklvMSEFMKQASMNWTRMSqaEKKRYDHLVEKDRLRFDEQFLDYK 327  Stylonychia lemnae

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