Conserved Protein Domain Family
ZnMc_hatching_enzyme
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cd04283: ZnMc_hatching_enzyme 
Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related metalloproteases, high choriolytic enzyme and low choriolytic enzyme (HCE and LCE), which may have different substrate specificities and cooperatively digest the chorion.
Links
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Statistics
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PSSM-Id: 239810
Aligned: 20 rows
Threshold Bit Score: 318.052
Created: 22-Jun-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
BAD95447   83 NGNVEIPFVLSDeydHNEKNQILKAMKGFEGrTCIRFVRHRGERAYLSIESKFGCFSLMGRSGERQLVSLQRpGCLNNGI 162 killifish
2661464    59 EGFVVIPYVVTDqydKENIDIAIDAMAEFDEiTCVRFVPRRTETDFLLIDSRSGCKSIIGKLGELQKISLEKmGCMNTGI 138 broad-fingered cra...
P42664    104 DGIVPVPYNLSYsynADQLALFKKAIQEFEAlTCVRFVPWTTEVNFLNIMSNGGCGSLIGKNGGAQRLELDAnGCMNMGI 183 African clawed frog
AAO15690   82 NGTVYVPYTLDEqynNDEINMITTTMQVYATlTCVQFVPYTNEDDYITIKSANGCWSFMGRQGGAQIVSVQKgYCTSEGT 161 African clawed frog
XP_421101 115 DGIVRIPYVLDPtyeENHVKGIREAMAEFETlTCINFVKRKTERDYLIIRSADGCWSNYGKVGGGQTISVMKgGCMWKGI 194 chicken
XP_426424 101 DGLVKVPVNISSdfsLAERSWIADALQEVSTlTCVKFVNRTTETDYVYVERGQSCWSYFGKIGGRQAVGLVKnGCMDKGA 180 chicken
AAH82956   83 DGIVYVPYTVSSqysDDEVSVITKAMEEYNGlTCLQFTPRTNEDNYVSIQSLDGCWSFIGLYGGSQAVSLMKgFCVYNGA 162 African clawed frog
CAG09305  105 DGFVYVAYRLSPnytELETRMIKRGMETIERgTCVRFVPRTHQEDFIDIKPKSGCWSYLGARGGRQTVSIQNpDCLRLGV 184 Tetraodon nigrovir...
XP_692624  66 DGFVYVPYIMSTlydDMDRMTIETGMLDISSsTCVKFVPLTHQANFLNIQPRYGCWSYLGMTGGSQTVSLQSpGCMWSGV 145 zebrafish
BAE97369   77 NGKVFVPYIISDeysTQEKDVIFQGFRSLEKsTCVRFRPRTTQRDYINIEPNSGCYSFVGRRTGGQTVSLDHdGCIKLNI 156 zebrafish

Feature 1       ##  #     #                                                                   
BAD95447  163 IQHELLHAMGFYHEHTRSDRDKYVKINWDNIQe----------------------------------------------- 195 killifish
2661464   139 IQHELEHALGFYHEHSRSDRDTYVKIMWENISp----------------------------------------------- 171 broad-fingered cra...
P42664    184 IQHELNHALGFYHEQNRSDRDDYVIIHTENIIp----------------------------------------------- 216 African clawed frog
AAO15690  162 TMHELNHALGFVHEQSRSDRDDYVDIMYQYISp----------------------------------------------- 194 African clawed frog
XP_421101 195 IQHELDHALGFLHEHSRSDRDKYVRIMWEYISpvsy-------------------------------------------- 230 chicken
XP_426424 181 IQHEMNHALGFIHEQARSDRDKFVKIMWEHITaaltgtntdgyygkrlalianlpaklselksqivqwekapmdlpehpk 260 chicken
AAH82956  163 VQHELTHALGFYHEQCRSDRDDYVTIMYQYISp----------------------------------------------- 195 African clawed frog
CAG09305  185 ITHEFMHALGFVHEQSRYDRDKYVTIMWPNIWr----------------------------------------------- 217 Tetraodon nigrovir...
XP_692624 146 ASHELMHALGFVHEQSRSDRDRYVSILWENIIe----------------------------------------------- 178 zebrafish
BAE97369  157 VQHELLHTLGFHHEHNRSDRDSHVQIVYKNIIp----------------------------------------------- 189 zebrafish

Feature 1                                                                                  
BAD95447  196 ------yYYKNFKKMDTDNL--TPYDYSSVMQYGKTAFGk-nRAESITPIPDpnvPIGQREGMSDTDILRVNKLYKC 263 killifish
2661464   172 ------dNVRMFDKEMNMQLg-LPYEYTSIMHYARYVYSi-eGDESIDPAPNgnvPIGQRDGISQYDIAKINKLYNC 240 broad-fingered crayfish
P42664    217 ------dFLKMFEKYNTNNLg-IEYDYASVMHYSRYHYSi-nGDITIEPKPDpnvPIGQRDGLSILDISKINKLYEC 285 African clawed frog
AAO15690  195 ------dDKVNFDKMDTNNVr-TRYDYQSIMHYPAWAYSnttEKNTIVAKPDpsvTLGAGSTMTSLDFTKINRLYQC 264 African clawed frog
XP_421101 231 ----itaDRPDFKKFENSNNlgLPYDYSSVMHYGPHTFTnttGKATIVPVPDgsvHIGQRLGLSNLDVAKINRLYNC 303 chicken
XP_426424 261 lsdvqvrEQGNFGKVNSKNLg-LPYDYSSVMHYGAYDFSstpGKPTIVPVPNplvPIGQREGLSNLDVAKINKLYKC 336 chicken
AAH82956  196 ------eDKVNFDKADTNNLg-VVYDYSSIMHYGSNAFSntsGENTIVPHPNpnvTLGQSYGLSNLDVLKINRLYGC 265 African clawed frog
CAG09305  218 ------dRLRNFEKFRTDTLd-LPYDYSSVMHFGMYTYSq-sGEPTIIPKNSnniKLGQVASLSKIDKLKINKLYDC 286 Tetraodon nigroviridis
XP_692624 179 ------nQRHNFRKYETNNLn-TAYDYSSVMHYGRYAFSe-dGGPTIIPKPDpyiPIGQRDGPSILDIHKINILYNC 247 zebrafish
BAE97369  190 ------gQERNFDKIKTNNLe-TAYDYSSVMHYGRFAFSk-nKEATIVPIPDsgvTIGRAKRMSSNDILRINRLYCS 258 zebrafish

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