2K7F,2EBU


Conserved Protein Domain Family
BRCT_RFC1
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cd17752: BRCT_RFC1 
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BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins
RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Links
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Statistics
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PSSM-Id: 349383
Aligned: 30 rows
Threshold Bit Score: 129.641
Created: 9-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2K7F: Homo sapiens RFC1 in complex with dsDNA through its BRCT domain, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ###      #            #####           #######  #                   
2K7F_A         28 GAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIR 106  human
CAB91757      339 GEIDCLAGKTFVFTGLLKTIAREEAQALVKRYGGKVTGAPSSKTDFVVLGDDAGPSKLRKIKEHGIKTIDEEGLFYLIR 417  Neurospora crassa
XP_001696917  385 GHPDCLTGKTFVISGVLDSLGREEATDYIKRHGGRVTGAVSGKTSFLVVGHHTGRSKYRKAREHGTKVIDEDGLFSLIR 463  Chlamydomonas ...
XP_001777721  147 GADDALANLTFVISGTLDSLEREEAEHLIKSHGGRVTGSVSKKTDYLLADEDIGGRKSQKAKELGVKFITEDGLFEMIR 225  Physcomitrella...
Q9C587        202 GTPDCLAGLTFVISGTLDSLEREEAEDLIKRHGGRITGSVSKKTTYLLCDEDIGGRKSEKAKELGTKFLTEDGLFDIIR 280  thale cress
ORX34720       93 GEPDCLAGLTFVFTGELDSLGRDEASELVKRYGGKVTGAPSSKTSYVVLGENAGPKKLETIKKNNIKTLNEDQFLDLIR 171  Kockovaella im...
XP_005840961  310 GAPNCLSGKTFVITGVLDCLERDEASDLIKGYGGRVTGSVSKKTDFLLCGEEPGDSKVKKAEELKVPKIDEAGLFQLIK 388  Guillardia the...
XP_002502824  202 GPNDCLEGVTVVVSGVLDSLEREEAEDYVKRHGGKVTSTVSGKTTYLLVGMDCGKSKYNKAKQHGTTLIDEDGLFAMVA 280  Micromonas sp....
XP_001744581    1 GALNCLGGLKFVITGVLESLEREDVQELVKDHGGVIQKSVSKRVDYVVAGDEPGPSKMSKARDLKLKVLDEDGLFELIR 79   Monosiga brevi...
XP_011401457  125 GHPDCLTGKTFVISGVLDSLKREEAEDLIRRHGGKVTGNVSGRTSFLVIGQYAGRSKHAAAQAKGTPVIDEGGLLSLVE 203  Auxenochlorell...

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