Conserved Protein Domain Family
ZnMc_ADAMTS_like
?
cd04273: ZnMc_ADAMTS_like 
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.
Links
?
Statistics
?
PSSM-Id: 239801
Aligned: 43 rows
Threshold Bit Score: 231.359
Created: 30-Jun-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Comment:Based on similarity to sequences with known structures.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
Q9P2N4     293 RFVEVLVVADnrmvs--------yhgeNLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQdgps----isfnA 360  human
BAD69559   184 LWLELAIVADntmlk-------fhgreRVKHYILALMNIVSAIFNDPSLGSNITLVINKLFLYEDKDiilk-----ygnI 251  domestic silkworm
XP_426316  572 YNIEVLLGVDdsvvr-------fhgkeHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKsisli---ergnP 641  chicken
XP_394544 1542 LTLELALFFDetgynlfs-pffdrndeKILDMLLAYINGIQAVYHHPSLGIAIDISLVRLEIMQKQPedlph---hdgeR 1617 honey bee
NP_611718  286 LFIETAIFVDsdlyahmqknfptntesKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDppglv---rsrdV 362  fruit fly
AAA83600   133 LTVELAVFADdamwdhfkkmygkaaeeNMHTFIMAVVNNIDVLYTQRLLQPRINIKIVRYEILKNIPhlmnarkhsngdV 212  nematode
CAA90302   233 ITLEIGLFLDsklfehfereyiqdaeqHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPsalstgvhkngqA 312  nematode
O95450     266 YNIEVLLGVDdsvvq-------fhgkeHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKsmsli---eignP 335  human
XP_700384  284 FNIEVLLGVDcsvvm-------fhgreHIQKYLLTLMNIVNEIYQDSTLGAHINVVLVRIMMLCSSKsmgli---elgnA 353  zebrafish
XP_967794  254 RWLEIALAVDhtliq-------fhgkdKVEQYVLALMNIVNAIYQDPSLEANMRLVVTRLLLYEHRKqsiv----rpgdA 322  red flour beetle

Feature 1                                                                                      
Q9P2N4     361 QTTLKNFCQWQHSKNspgg----ihhDTAVLLTRQDIcra---hdkCDTLGLAELGTICdpYRSCSISEDs--------- 424  human
BAD69559   252 KKSLEAINKWNYRHLmklpe-gstgwDATIWLTRSQL---------GGPSGFAPVGGVCtkTRSAAIDRDe--------- 312  domestic silkworm
XP_426316  642 SRSLENVCRWAYQQQksdpn-hsehhDHAIFLTRQDFg-------pAGMQGYAPVTGMChpVRSCTLNHEd--------- 704  chicken
XP_394544 1618 GKLLDSFCNYAKKNNpanef-npnhwDMGLYVSGLDFyvmeggqknSATMGLAIVNGLCieQYSCVIAELgvtnqfgkpf 1696 honey bee
NP_611718  363 ENYLNSFCKWQEKLNpfsda-dplhyDHALVLTGLDLvtydkgkanSQVVGMATVKGMCtsIYSCTINEAk--------- 432  fruit fly
AAA83600   213 DRLLDAFCQYQNEINppnda-dprhwDHALLFSGYDLhrn----gvKTVAGYAPVKGMCsgVRSCTINEGl--------- 278  nematode
CAA90302   313 QSLLDAFCRYQAHMNpgtdltdmnhyDHGVLLTGYDIyh-----ttTSVAGVAPVARMCdpLFACSLVEGl--------- 378  nematode
O95450     336 SQSLENVCRWAYLQQkpdtg-hdeyhDHAIFLTRQDFg-------pSGMQGYAPVTGMChpVRSCTLNHEd--------- 398  human
XP_700384  354 SQSLENVCRWAFLQQkedkn-daeyhDHAIFLTRQEFg-------pTGMQGYAPVTGMChpVRSCTLNHEd--------- 416  zebrafish
XP_967794  323 KKSLENANSWNSRLHaslap-deshhDIAVWLTRSDI---------GGPSGYAPVAGACdpKRSCALNRDe--------- 383  red flour beetle

Feature 1                  ##  #     #                                                         
Q9P2N4     425 ---gLSTAFTIAHELGHVFNMPHDDn----NKCKEegvkspQHVMAPTLnfytnpWMWSKCSRKYITEFLDtgy-----g 492  human
BAD69559   313 ---gLTSAFVIAHELAHLLGLTHDGe----GNCQSea--lrGSVMAPTVlatlhnFAWSSCSKEQFHAKSKkw------- 376  domestic silkworm
XP_426316  705 ---gFSSAFVVAHETGHVLGMEHDGq---gNRCGDet--amGSVMAPLVqaafhrYHWSRCSGQELKRYIHsy------- 769  chicken
XP_394544 1697 psagFTSIYVAAHEMGHNLGMHHDSt---gNTCPKd-----GYIMSPSRgiy-geTIWSECSREVAQKLPYtk------- 1760 honey bee
NP_611718  433 ---hFESVFVVAHEIGHNLGMRHDAk---eISCDPt-----MHIMSPKLgs--gkVTWSKCSRTYLEDFLMdpq-----a 494  fruit fly
AAA83600   279 ---dFGSVFVVTHEMGHSLGMYHDGd----NECDLr-----CCIMSPSVgs--gkTHWSQCSVNEMATFVGhlgddfrpp 344  nematode
CAA90302   379 ---hLGRSFVLAHEMGHNMGMVHDGv---qNQCNKg-----CCLMSAVNga--gkTTWSDCSVREFNAFLLqldes-grg 444  nematode
O95450     399 ---gFSSAFVVAHETGHVLGMEHDGq---gNRCGDev--rlGSIMAPLVqaafhrFHWSRCSQQELSRYLHsy------- 463  human
XP_700384  417 ---gFSSAFVVAHETGHVLGMEHDGq---aNECGDev--pmGSIMAPLVqaafhrFHWSRCSQQELRRYLNty------- 481  zebrafish
XP_967794  384 ---gLTSAFIIAHEMAHVLGLSHDGdkkhsNHCGDes--akGSVMAPLVaatfhqFFWSQCSRKEFKKIVKkw------- 451  red flour beetle

Feature 1          
Q9P2N4     493 eCLL 496  human
BAD69559   377 wCLH 380  domestic silkworm
XP_426316  770 dCLL 773  chicken
XP_394544 1761 sCLR 1764 honey bee
NP_611718  495 eCLF 498  fruit fly
AAA83600   345 nCLQ 348  nematode
CAA90302   445 nCLR 448  nematode
O95450     464 dCLL 467  human
XP_700384  482 dCLR 485  zebrafish
XP_967794  452 tCLS 455  red flour beetle

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap