3G1U,1V8B


Conserved Protein Domain Family
AdoHcyase

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pfam05221: AdoHcyase 
S-adenosyl-L-homocysteine hydrolase
Statistics
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PSSM-Id: 461594
Aligned: 144 rows
Threshold Bit Score: 758.517
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3G1U_C               3 DYKVKDISLAEWGRKAIELAENEMPGLM--ELRREYGPSQPLKGAKIAGCLHMTVQTAVLIETLKALGAELRWSSCNIFS 80  Leishmani...
jgi:Rmag_0739       19 DYKVADMALADYGRKEIELAEAEMPALM--TLRKKYQSTQPLKDAKILGCIHMTIQTAVLMETLINLGAQVRWSSCNIFS 96 
zhongguo:B5T_00252  10 DYKVADISLAQWGRSEIEIAETEMPALM--AIRAKYRAEQPLKGARIIGCIHMTIQTAVLIETLKELGAEVRWSSCNIFS 87 
Q5R045               8 DYKVADISLAEWGRKEIAIAESEMPALM--TIRRKYADSKPLAGARIIGCIHMTIQTAVLIETLLELGAEVRWSSCNIFS 85  Idiomarin...
XP_002111388        31 DFCVKNIKSAEFGRREIEIAEQEMPGIM--ILRVKYAENKPLQSARIIGCTHITAQTAVLIETLITAGASVRWAACNIYS 108
P50245              67 DFCVKSISKSAFGRREIEIAESEMPGIM--TLRKRAKDEKPLKGANIVGCTHVNAQSAVLIETLVQLGATVRWAACNIYS 144 fruit fly
XP_001625738        53 DFCVKNIKLADFGRREIEIAEQEMPGLM--LLRKRNCTDKPLEGAKIVACTHVTAQAAVLIETLMALGAQIRWCACNIYS 130
NP_001074118        71 DFCIKNIKLADFGRRQIELAEDEMTALM--ALRKAAQGEKPLAGAKIVGCTHVTAQTAVLFETLSGLGAQCRWAACNIYS 148
XP_029698134       100 DFCIKSIKQAHFGRREIEIAEQEMAALM--FLRKRVGGEKPLAGAKVMGCTHITAQTAVLIETLSVLGAQCRWAACNIFS 177 torafugu
XP_019217049       142 DFCIKNISQADFGRKEIEMAGREMPALMnlR--KRAGGEKPLAGAKVVGCTHITAQTAVLIETLVALGAQCRWAACNIFS 219 Nile tilapia
3G1U_C              81 TQDNAAAAIAKTGVPVFAWKGETDEEYEWCIAQTVK------GfsgDGl-PNMILDDGGDLTNLVIDRYPELVPKIFGIS 153 Leishmani...
jgi:Rmag_0739       97 TQDHAASAMVAANIPTFAWKGETEEEFLWCIEQTILeng-kpWa------ANMVLDDGGDLTQTLHEKYPEMLDNIHGIS 169
zhongguo:B5T_00252  88 TQDHAAAAIAASGVPVFAWKGETEEEYMWCIEQTCRdgdgnlWd------ANMILDDGGDLTAYIHDTYPEMLDNIHGIT 161
Q5R045              86 TQDHAAAAMAAAGVPVFAWKGETEEEYDWCLKQTCHkdg-elWd------ANMILDDGGDLTLMIHDEFPQMLEKVHGIT 158 Idiomarin...
XP_002111388       109 TQNEVAAALAEEGIPVFGWKGMSEDDFWWCIEKASNhq---nWq------ANLILDNGGDATHYMKRKYIDKFRCLKGIV 179
P50245             145 TQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYsd---gWq------PNLILDDGGDATHLMLKKYPDYFKAIRGIV 215 fruit fly
XP_001625738       131 TQNEVAAAMAESGLSIFAWKGESEEDFWWCIEKCITsn---gWq------PNMVLDDGGDATHLMYKKFNGTFNTLKGIV 201
NP_001074118       149 TQNEVAAALAERDFPVFAWKGESEDDFWWCIDRCVNve---gWe------PNMILDDGGDMTHWIYKKYPHIFKKVKGIV 219
XP_029698134       178 TQNAVAAALAEQGTAVFAWRGESEDDFWWCIEKCVGae---sWq------PNMILDDGGDLTHWIYKKHPGLFRNLKGIV 248 torafugu
XP_019217049       220 TQNAVAAALVKAgisVFAWRGESEDEFWWCIDHCVG------T---ETwqPNMILDDGGDLTDWIYKKYPELFKNLKGVV 290 Nile tilapia
3G1U_C             154 EETTTGVKNLYKRLSKGNLPISAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKTCCVCGYGDVGKGCAAALRA 233 Leishmani...
jgi:Rmag_0739      170 EETTTGIHRLLKMMEKGSLKVPAINVNNSVTKSKNDNKYGCRHSLNDAIKRGTDMLMSGKKALIIGYGDVGKGSAQSLRQ 249
zhongguo:B5T_00252 162 EETTTGVHRLYDMLKKGTLKVPAVNVNDSVTKSKNDNKYGCRHSLNDAIKRGTDHLLSGKKALVVGYGDVGKGSAQSLRQ 241
Q5R045             159 EETTTGVHRLLDMLEKGTLKVPAINVNDAVTKSKNDNKYGCRHSLNDAIKRSTDHLLSGKKALVVGYGDVGKGSAASLRQ 238 Idiomarin...
XP_002111388       180 EESVTGVHRLYQMTKNNCLPIPAMNINDSVVKGKFDNLYCCREAVIDSLKKTTDIMFGGKQVLICGYGEVGKGCCSALRG 259
P50245             216 EESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFDTFYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKG 295 fruit fly
XP_001625738       202 EESVTGVHRLYQLSKQGKLTVPAMNVNDSVTKTKFDNLYCCRESILDSLKRTTDVMFGGKQVLVCGYGEVGKGCCAALKG 281
NP_001074118       220 EESITGIHRLHHLSKAGKLCVPAINVNDSVTKQKFDNLYCCRESILDSLKKTADIMFGGKQVVVCGYGEVGKGCSAALKA 299
XP_029698134       249 EESVTGIHRLYQLSKAGKLCVPAINMNDSVTKQKFDNLYCCKESVLDGLKRSTDVMFGGKQVLVCGYGEVGKGCCAALKA 328 torafugu
XP_019217049       291 EESITGVYRLYQLSKAGRLSVPAMNVNDSVTKQKFDNLYFCKESVLEGLKRTTDIMFGGKQVVVCGYGEVGKGCCAALKA 370 Nile tilapia
3G1U_C             234 FGARVVVTEVDPINALQASMEGYQVALVEDVMADAHI---------------FVTTTGNDDIITSDHFPHMRDDAIVCNI 298 Leishmani...
jgi:Rmag_0739      250 EGMIVKISEIDPICAMQACMDGFEIISPYINGINKGSidginkdllnttdliVTATGNINVCDNAMLQTLKPGSVVCNIG 329
zhongguo:B5T_00252 242 EGMIVKVTEVDPICAMQACMDGFEVVSAFKNGVNDGTaasvntdllgntdllVTTTGNFNVCDANMLKALKKGAVVCNIG 321
Q5R045             239 EGMIVKISEIDPICAMQACMDGFEVVSPYLEGKNNGTgdninkdllsntdliVTTTGNMDVCDRYMLAALKPTALVCNIG 318 Idiomarin...
XP_002111388       260 MGAIAYVTEIDPICALQACMDGFKVIRVDDAIRIVD----------------IVITATGNKNVIRREHMNKMKNGCIICN 323
P50245             296 QGCIVYVTEVDPICALQAAMDGFRVVRLNEVIRTVD----------------VVVTATGNKNVITRDHMNRMKNGCILCN 359 fruit fly
XP_001625738       282 LGAIVYITEIDPICGLQACMDGFRVVKIEEVCKHID----------------ILITCTGNKNVVTREHLDRLKNGCIVCN 345
NP_001074118       300 MGSIVYVTEIDPICALQACMDGFRLTKLSDVVRQVD----------------MVITCTGNKNVVVREHMDVMKNGCVVCN 363
XP_029698134       329 VGAVVYVTEVDPICALQACMDGFRVVKMKEVVRRVD----------------MVITCTGNKNVVVRKHLDRMKNGCIVCN 392 torafugu
XP_019217049       371 LGAIVYVTEVDPICALQACMDGFRVIKLSEIVRHID----------------MVITCTGNKNVVMREHLDKMKNGCIVCN 434 Nile tilapia
3G1U_C             299 GHFDTEIQVGWLEANAKEHVEIKPQVDRYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSFTNQVLAQIELWSnRd-n 377 Leishmani...
jgi:Rmag_0739      330 HFDNEIDTQYMLDNWLWDEVKPQVHRIFRTDNKSDYLILLSEGRLVNLGNATGHPSRIMDGSFANQVLAQIHLFN-A--- 405
zhongguo:B5T_00252 322 HFDNEVDTAFMRKTWEWEEVKPQVHKVWRDKAEGDFLLLLSEGRLVNLGNATGHPSRIMDGSFANQVLAQMYLFD-Qgya 400
Q5R045             319 HFDNEIDTAFMRKNWRWEEIKPQVHKIYRSDDDNDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIHLFE-Qkfa 397 Idiomarin...
XP_002111388       324 MGHTNSEIDVDSLRTPDLTWERVRSHVDHIVWPDGRRIVLIAEGRLANLTCSNVPSFVVSITACTQMLALIELFK----- 398
P50245             360 MGHSCSEIDVNGLHTPELTWERVRSQVDHIRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFS----- 434 fruit fly
XP_001625738       346 MGHSNTEIDVASLRTSDLAWEKVRSQVDHIIWPDKKRIVLLAEGRLVNLSCSSVPSFVVSITATTQAIALIELYK----- 420
NP_001074118       364 MGRSNTEINVSALKTPDLTWQHVRAQVDHIIWPDGKRMILLAEGRVLNLSSSTVPIYVLSITATTQALALIELFN----- 438
XP_029698134       393 MGHSNTEIDLASLRTAELRWERVRSHVDHVIWPDGKRILLLAEGRLLNLTCSTVPSLVLSITTTTQALALIELYS----- 467 torafugu
XP_019217049       435 MGHSSSEIDLAGLRSSDLKWVHVRPRVDHVIWPDGKRIVLLAEGRLLNLSCSTVPSFVLSITAATQAMALIELYN-Ap-- 511 Nile tilapia
3G1U_C             378 GK-YPRGdk-agVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEYINCPVNGPFKPDHYR 436 Leishmania major
jgi:Rmag_0739      406 KFaD--KggdiyVKVLPKKLDEEVASGMVSGFGGVLTVMTTTQANYINVPKNGPFKPESYK 464
zhongguo:B5T_00252 401 NHsDAVKekmlkVEVLPKHLDEEVAMYMVQGFGGVVTRLTAEQADYIGVSVDGPYKPDHYK 461
Q5R045             398 DMeIKQQeeylrVEVLPKQLDEEVARYMVQGFGGVITKLTADQANYIHVDVEGPFKTDEYR 458 Idiomarina loihiensis
XP_002111388       399 ---AQPNkykgdVYLLPKKMDEYVASLHLAGFEAQVTELSDDQCQYLGVARNGPFKPNYYR 456
P50245             435 ---AP-GryksdVYLLPKKMDEYVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYR 491 fruit fly
XP_001625738       421 ---APPGrykhdVYLLPKKMDEYVAMLHLPTFDAHLTDLSDDQAKYLGVNKNGPYKPNYYR 478
NP_001074118       439 ---APEGrykqdVYLLPKKLDEYVASLHLQTFDAHLTELTDDQAKYMGLSKNGPFKPNYYR 496
XP_029698134       468 ---APEGrykqdVYLLPKKMDEFVASLHLPTFDAHLTELSEEQAKYLGISRSGPFKPHYYK 525 torafugu
XP_019217049       512 EGrYNKD-----VYLLPKKMDEYVASLHLPIFDAHLTELSDDQAKYMGISKHGPFKPNYYR 567 Nile tilapia
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