1JFZ,1O0W,1I4S,1RC7


Conserved Protein Domain Family
RIBOc
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cd00593: RIBOc 
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RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing.
Links
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Statistics
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PSSM-Id: 238333
Aligned: 197 rows
Threshold Bit Score: 51.0743
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1JFZ_A     20 SLLEKALTHVSyskk----------------------------------------------------------------- 34  Aquifex aeolicus
CAB80416  400 LGLQLCFLHPSkhkfeh--------------------------------------------------------------- 416 thale cress
NP_915922 396 LGLQLCFLHPSkhkfeh--------------------------------------------------------------- 412 Japanese rice
NP_783135   4 YFLGEEFTKQDlkq------------------------------------------------------------------ 17  Clostridium tetani...
NP_349753   4 NILNDKFTKTRavq------------------------------------------------------------------ 17  Clostridium acetob...
2632362     5 DTIKDSKQLNG--------------------------------------------------------------------- 15  Bacillus subtilis ...
AAV44116    7 TTMVAAVHHPRpcfrvraawdmnpsaspkpkakpppppppplptapapthadlfarhsnsegqvpkkttsmgferwwlpp 86  Japanese rice
AAL66948   54 SVADLLKRPSSkeitvdvddtymgyetw-------------------------------------------------sps 84  thale cress
1653508     8 PLWQSSLNPADapavq---------------------------------------------------------------- 23  Synechocystis sp. ...
NP_681218   4 FGELLPLQPPTipah----------------------------------------------------------------- 18  Thermosynechococcu...

Feature 1                  #  #   #                                                           
1JFZ_A     35 ----------ehyETLEFLGDALVNFFIVDLLVQYspnkrEGFLSPLKAYLIs---EEFFNLLAQKLELh------kFIR 95  Aquifex aeolicus
CAB80416  417 --------prfcfERLEYVGQKIQDIAMAERLLMKhl-daPGKWLQEKHRRLl--mNKFCGRYLREKRLh------nFII 479 thale cress
NP_915922 413 --------prfclERLEYVGQKIQDLVMAERLLMKhl-daPGRWLAEKHRRLl--mNKYCGRYLRDKHLh------hYII 475 Japanese rice
NP_783135  18 ----------mnpLVLAYIGDAVYEIFIRTYIISKnkdtcVNKLHKKTIQFVk---ADAQSYFIREIQK--------YLN 76  Clostridium tetani...
NP_349753  18 ----------lnpLVLAFVGDAVYENFVRIYIVDKy---dEMTVHRLHIKAIefvkAHAQSTFMKEIYD--------ELN 76  Clostridium acetob...
2632362    16 -------------LALAYIGDAIFEVYVRHHLLKQgf-tkPNDLHKKSSRIVs---AKSQAEILFFLQNq------sFFT 72  Bacillus subtilis ...
AAV44116   87 ppevkkprslynaASLAYLGDCIYELYARRHFFFPpl--sINDYNKRVMDVVk---CESQDLLLNKLLGe------dFLT 155 Japanese rice
AAL66948   85 ppklekprsvfnpASLAFIGDSIYELYARRHFLFPpl-siEDYNDRVRAVVR----CEAQYALLNKLVDd------dFLT 153 thale cress
1653508    24 ---------slspVALAYLGDAVFELYVRCCYLFPpr--rIGDFHRRVVAQVr---AEQQAQILTTLLPqltdpekeWVR 89  Synechocystis sp. ...
NP_681218  19 ---------qlppAALAYFGDAVYELFIRLLFLTPpq-riNAYHRQVVAHVR----AESQARYMDFLWEy------cTET 78  Thermosynechococcu...

Feature 1                                     #  #                                         
1JFZ_A     96 IKRGk--------------------iNETIIGDVFEALWAAVYIDsgrdanfTRELFYkl-------fKEDILSAIK 145 Aquifex aeolicus
CAB80416  480 YSEEvhdrye-----------hnrrlRNPATTAVQQAIHGLAYTIygk--pdVRRLMFe---------VFDFEQIQP 534 thale cress
NP_915922 476 YGESvqdrfe-----------hnrrlRNPSTTAVQQAIHGLAYCVygk--pdVRRLMFe---------VFDFEQVQP 530 Japanese rice
NP_783135  77 EEEIkvfkrgrntk--sntsaknasiQDYRMATGFETVIGYLYLLned--erLEEIMKl--------vINLYEESSQ 141 Clostridium tetani E88
NP_349753  77 EEEVriykrgrnak--satspknadiCEYRASTGFEALIGYLYLTnq---idRLNFILe--------kVVEIKENSK 140 Clostridium acetobuty...
2632362    73 EEEEavlkrgrnak--sgttpkntdvQTYRYSTAFEALLGYLFLEkke--erLSQLVAeaiq--fgtsGRKTNESAT 143 Bacillus subtilis sub...
AAV44116  156 QEERdilrwgrnivssktrtrkragiAVYNRASSLETLIGYLYLTnf---krLEQLMFqlgft-sgasSHHIADELV 228 Japanese rice
AAL66948  154 KEERdilrwgknlgsartrtrrragnAVYNKASSLETLIGYLYLTng---krLEKIMEklgfssdsstEIVIEETNP 227 thale cress
1653508    90 RGRNaatsts-----------rranpELYQAASGLETLLGYLYLRda----rRLDELLa---------LIELPDAAP 142 Synechocystis sp. PCC...
NP_681218  79 ERSIfrqgrnaaa-----dgpkrvaaKIYRQATGFEALLGYLYLTnp---qrLQEIFQl--------lAGHIRSEVE 139 Thermosynechococcus e...

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