Conserved Protein Domain Family
LasB

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COG3227: LasB 
Zn-dependent metalloprotease (Neutral protease B) [Posttranslational modification, protein turnover, chaperones]
Statistics
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PSSM-Id: 442460
Aligned: 208 rows
Threshold Bit Score: 235.359
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_714341       1 MENfkwlridlrlkil-----icifsilfsckdNKQefgesw-islfnNVKmdekaisdrhyss---------------- 58  
WP_063610305    1 --------------------------------maatlttalslvtggpAQAadpppaqvetrt----------------- 31  
WP_013766274    1 MRIifticscmlfvqlyaqfkpvppqrstqgnkTTTahhaikplsrfsAAGqtpsvqatadyanlpklnlaqrkaipgpv 80  
WP_015100225    1 MRKslagaa----------------------------------------------------------------------- 9   
WP_082083047  123 TKSlryrgdgedatvr---------------------------------------------------------------- 138 
WP_013995234   67 MPSvfqitsgdavyehevi------------------------------------------------------------- 85  
WP_062151957   68 LRSsnpiniqwnkngtpr----------------eikggilqtantisANSlqt-------------------------- 105 
WP_110168929    1 MATksakksakkta--------drkagatlrsnGLSrfn-------mhALDkkserlfsalrser--------------- 50  
WP_080040295    1 MSWrpiilital---------------------------ctalsvpgvAAAedpppevearag----------------- 36  
WP_111372300    1 MKRilhfvfivlitsg----afaqsgfdaktkkNKAapqlehvfqeisGQQsgntnlrkkaiqsgvelrssid-----yk 71  
NP_714341      59 ------dgtltfatfnsdlVp----yNRKQAPEVLKTYL----------------------QLTLNSEpvflRSNHiGDY 106 
WP_063610305   32 -------gtdapalvsglaEa----pRNGDPVAVARGHLrdgryg----------iknvdtDLAPLDV----VRD---GA 83  
WP_013766274   81 iirdeksalpiyiegeasgLpe---lRDAPNSKRANLYLehfkrel--------ridapaqEFLLVAQ----HTDD-QQQ 144 
WP_015100225   10 -------------vlaalaAt----vLPGGPAAHA-DDLtlara------------atggvELAPLST-----TDS--GD 52  
WP_082083047  139 ------llaapalilpkdpAn----pKAESPEAMTKRFLsenrell--------liknpsaEFTVTSV----ETQP-KGD 195 
WP_013995234   86 ---grsedgiplfikskagKevasltAKQSSEQVIKDYLagvkhli--------qvkdpdaEFVEISK----HTDA-LGQ 149 
WP_062151957  106 -----------------------rsgKTTQNETTARDFLrinrfll--------kiqnpdqEFALHQV----QYDTlNSN 150 
WP_110168929   51 -------------rdfagfagaatnvSEMDPESAARLYLkqalesdsvpglvapvadgavsEYRTLGT----ESIPlTGT 113 
WP_080040295   37 --------tqapaevrglsEp----aKAGDPVAAAKAHLadpry------------hlnpaDLAPLRT----VKD---GQ 85  
WP_111372300   72 tyrdsesgsvifiennktgLsv--rqQRKTATAQAYDFLeevkgql--------kvtnpknEFSAISN----NTDE-QGL 136 
NP_714341     107 -DHDRFQQRYKGIKVENGTYTVVSKRNT----IESMMGEFyQVPe-nFNSSPKLSESEAFSKALKHFGAKKyiwespere 180 
WP_063610305   84 dETVRFEQRHQGVRVFGAHYLVQMSKEGdahkVTGAGGRFlTRLn--VSTTPRFPQRLALNVARSRVAAESggd------ 155 
WP_013766274  145 -THLRFRQQYQGIEVYGAEILLH-EKNGk---IDLFNGRYfPTPq-lKSVQAKLNEPAAIQLALQDLGQKEkvkaldp-- 216 
WP_015100225   53 rSTVRFGQRHRGVPVFGAQTLVHLAGPAaertVRATTDRTaRGLt--VDTTPTVSEDRAVGGALAALDPQTr-------- 122 
WP_082083047  196 -TVLRLSQKLGDLDVWPGQITANVSEAGy---LTVITGAYaPTPe-gIKTTPAITTEQAQAAALQHANEDNs-------- 262 
WP_013995234  150 -KHIKMQQVFKGIKVYGGELILHLDQGNk---VDAMNGRNkPTPs-iERTQPKLSVQDALQRVEKDLGVSFptktgk--- 221 
WP_062151957  151 -TRLRFTQQYAGLEVWPAEIGVRLDAQGn---VVMMNGIYaATPrhpLNVTPQISAEQARNQVMSSYp------------ 214 
WP_110168929  114 -TMVKFRQQLNKIPVYGSLVSVELDEKNs---LLSVTSACgKPSn--VSAVAKISPAEAMDTVKRAPGLKK--------- 178 
WP_080040295   86 dETVRFAQRYRGLPVFGAHYLVHFRTEGgqreVVGAGGRFlTELs--VDPAPAVKKESAAKIARSLMARPYga------- 156 
WP_111372300  137 -SHLKFQQEYNGVKIYGAEIVTHADDKK----VKTLNGKVfPTPn-nLSLKPKIDKKEAIILGLKELAKISiiqkdg--- 207 
NP_714341     181 eafkkkqddpsATNFPKGE-LLVYQhslgklnsQKE-FRLVYKFG---IVSi-------ePSSSRYVYVDSHSGEILANM 248 
WP_063610305  156 ---------kaGLTAEPGG-LTVVP--------VGK-GLLAWQVT---VRGtda---rkrMPLLADVYVDARTGAPLFAS 210 
WP_013766274  217 -----leiemvGPQIAKKQ-LVIYHtg-----eEKNiPKLCWYLE---IAPt--------VLSRWAYFIDAENGAVLKKY 274 
WP_015100225  123 ----------sRAKTERHG-LVVLP--------NGP-GVLTWHLT---VRGedv---pkgQPMRREVYVDAHTGAVALEY 176 
WP_082083047  263 -----------SLSVNQPPiLKIFAd-------KGRvPELSYEVQ---VEG---------ANRHERVFISALTGDVLLSV 312 
WP_013995234  222 ------tnsvfLNSDYEEE-LLIYPf-------EGK-NVLARHLT---VHPn--------IKDRWEYFIDAQNGRILNKI 275 
WP_062151957  215 ----------vDTQATQPV-LIIYAt------vDQE-PRLAWRFQ---VLAr--------LDQRIMVVVDALSAKVLAEF 265 
WP_110168929  179 -----------ALDGITPQ-LNYYYda-----dDSKw-RLVYIAQdvpVGPahkgktavrVPLRMDFVVDAHTGKLVKEL 240 
WP_080040295  157 ---------peGLAARTGE-LVVVP--------RGA-GVLAWHVV---LSGkdr---tarRPVLLDAYVDAHSGRPLFAV 211 
WP_111372300  208 -----fengffEIAQDQAD-LVIYHk-------EEI-PVLAYEMT---LKPn--------LLERWVVFMDAQTGEIIDKY 262 
NP_714341     249 DANRYeAGggdttpttpqtppdth----ygicfpdktpcikqgtAATRFsgiqsiitwtteadh-------------fel 311 
WP_063610305  211 SRIRTvAEgpv------------------------------vtsGTTVRgrnvplnahqradgkyel-------rdrara 253 
WP_013766274  275 SLLCK-LHhnigkstsapahfhshisieeekvtpslldgkttanATDLNgvtqkintyqvgatyflidaskdmfdlatsq 353 
WP_015100225  177 DNLHF-AEgpa------------------------------tgeGVAANgktkplavyeradgrfel-------rdrsra 218 
WP_082083047  313 SEICT-GAtt--------------------------------gtGTDTRgysrslnvysdgapvkyyll----dtskpmf 355 
WP_013995234  276 YHTCT-LYheygkegherg---------------rlapppsntsGTDLNgvtrqldtysidgknymintsksmfnsgqsk 339 
WP_062151957  266 NQIHG-AAvt--------------------------------gsGQDLTgqvrtinvfekegryvlndtskpmfaqyglt 312 
WP_110168929  241 PRTAMmAAvt--------------------------------eaAVDGFgtsrtfeaaktgak----------------k 272 
WP_080040295  212 DRLR--FEgpv------------------------------qgsGQTAHgqtvplnayqradgayel-------rdrtrp 252 
WP_111372300  263 NHTCTldgv-------------------------------fqtsAKDLNgftrsfniiqsgssyfmldpskpmfdngqsk 311 
NP_714341     312 kdysrgkgivsySWEf---vRvapsAl---E-TvkiPl----IDTDnnwtkaeyhdDyNHDAVlDAHWGIEHTYDYFKSV 380 
WP_063610305  254 mwngttgeiltyDGQerdvyEf--lGe-----L---PadtpvVDSDtpaf---tgkA-SEIGAvDAHWGAGQVYEYYRR- 318 
WP_013766274  354 mprspqgaiitlDVR-----N----Kin-aDgsfq---sfffTNNNns---------wGDPAAvSAHFNAGMVYDYFRSK 411 
WP_015100225  219 mfpatggeiltyDAEkrdyyDf--lGe-----F---PpetklFAADttrf---dgaA-AETGGvDAHWSAGQVYEFYRQR 284 
WP_082083047  356 nastfngyigifNAA-----N----Al---N-Is-------fSTQLn--------sG-YDPEGvGASFNMGKVYDFYKNV 406 
WP_013995234  340 ipdnpvgaimtwDLK-----N----KapeeDatf-----yyvTSTTst---------wNDPVAvSAQYNAEVSYDYFEKN 396 
WP_062151957  313 epdvnlgtiliyDAQ-----H----Ad--aEiVq--Psi-lsSTTNn----------nFLADGvSAAYNISEVYDYFLQK 368 
WP_110168929  273 tmvdaslniqtfDFRfkdldNp---An---A-L---Pgg-lvANPP----------T-WDPGAvSAHANAAVVAKFMRDT 330 
WP_080040295  253 mwngttgeiltyDAKggevfDy--lEp----gI---PpgtelARSAtpvf---gpeH-TQTGAvDAHWGAGQVYEYYRG- 318 
WP_111372300  312 lpdapvgavwtiDAL-----D----Sr--iSgeme---fahvTSNDg--------tT-WSPTAvSAHNNASICYDFYRTK 368 
NP_714341     381 HNRSSFDGEDAKIVNNVHYt--------KvlNFNNAHWNPitEELEYTycphdsslcHGiNDeillDpRFEDFT-SLDIA 451 
WP_063610305  319 LGRNGLDGEGGSMSSVVNVtd-----sgR--PFINAFWDG--AKMVYG---------GG--G----D-AAYSLAsALDVV 373 
WP_013766274  412 FTRKSINGDGGSIRSYVNVpde----dgT--SLENAFWNG--DAMFYG---------NG--G----K-ELRSLArALDVA 467 
WP_015100225  285 LGREGIDGKGGSSVSVAGVtn-----rgR--PFLNAFWDG--RKMVYG---------WA-TG------ERLPLSaDLDVV 339 
WP_082083047  407 FGRNSYDNNGASIMSVIRQanp----dgS--PMENAYWDG--SKMAFG---------TA-D----------RYTaATDVV 458 
WP_013995234  397 FDRSSINGQGGTIISIVNVaad----dgG--GYDNAFWNG--KAIFYG---------NG-KA------AFSPLAgALDVG 452 
WP_062151957  369 QERNSINGQGGSIIGIVRVg--------E--NYDNAFWNG--SAMYFG---------DA-----------RPYAaSSDVV 416 
WP_110168929  331 LSRNGLDNRGGTLISSINCiassepagpR--EWFNAAWVG--TQMVYGqr------rNG-------T-SMLSLSaNVDVV 392 
WP_080040295  319 LGRDGLDGQGGTMYSVVNVtl-----dgQ--PFANAFWDG--TKMVYG---------GG--G----P-EYHSFAaSLDVV 373 
WP_111372300  369 FDRNSLNGKGGNIISVINItde----dgK--GMDNAYWNG--EFMGYG---------NG-A-----Q-GFKPLAgALDVA 424 
NP_714341     452 SHEFGHAINAYAAGFDYNAESAALDEGFGDIWNVGVNHYvnkilgmHKNVWRFGDETVLN----G-GMRSLQYPNSATpv 526 
WP_063610305  374 GHEMTHGVVEHTAGLVYFGQPGAMNEGLADYFGNAVQAEvegidlaDPDAGLLGESYCRTlpprecAFRDLNDGRT---- 449 
WP_013766274  468 GHEITHGIIQNTANLEYEDEPGALNESFADVFGAMID----------RDDWKMGEDVVVLsafpSgALRDLSNPNNGGrs 537 
WP_015100225  340 GHEMTHGITEHTAGLVYLGQSGAINEAVSDYLGNAIDVTvtgtpmtDPNAGLLGEDLCRTtapeecAIRDLNDGRT---- 415 
WP_082083047  459 GHEFTHAVVTATSDLIYKNESGALNESFADVFGEAIERVvy-----gSNDWLMGSFLSV-----GgPIRSMQNPQIYG-- 526 
WP_013995234  453 GHEMSHGVIEATANLEYSYQSGAINESFADIFGTMID----------RDDWLLGEDIVNReyfnSgAMRNLQDPNN-Gas 521 
WP_062151957  417 GHELTHGVVEYSAGLVYEGQSGALNEAFADIFGEMTQTRtq-----gQPDWIIGGQEL------GvTIRSFTNPEAYD-- 483 
WP_110168929  393 GHEMFHGVTDHTSRLEYQGQAGAMNESYSDIFGILISNLgk---alGAFDWELGERLFAN----GrPLRDLSDPTRFS-- 463 
WP_080040295  374 GHEMTHGVIEHSADLVYLGQSGAMNEGLADYFGNAIQVDtfgipmsDPDASLLGEGLCKTlppaecAGRDLDDARV---- 449 
WP_111372300  425 GHEMTHGVIENTARLEYRNQSGALNESFADIFGALID----------RDDWTLGEDVVKSnvfpSgALRSLENPNQGGqn 494 
NP_714341     527 t---lgGADTYygdlW---------DFTNKKTHENGLVLGHWFYILSNGKSGindhscE-YnTTGI-SIEKAEKIAYSTI 592 
WP_063610305  450 ------GPADYvga---------tgRIDNAGVHLNSTIFSGALWDIREKL------------------GSRTDKIAYKAL 496 
WP_013766274  538 lndpgwQPAHY----Sery----tgTQDNGGVHINSGITNRAFFLFAT----------------QV-GKDMAEQVYYTAL 592 
WP_015100225  416 ------TVHDYlgv---------tnNTDNGGVHLNSTIFGGALWDIRERL-----------------DPALADKVVYTAL 463 
WP_082083047  527 ------DPSKM----Sefl----rtEADDGGVHSNSGIPNKAFYLLAEGL--------G---TGGI-GFDSARNIFYRAL 580 
WP_013995234  522 qgqrgwQPKDM----Teyy----sgEEDNGGVHMNSGIVNRAYYLIAT----------------DI-GKDKAEQIYYRAL 576 
WP_062151957  484 ------QPSTM----SsyqtlpnteDGDNGGVHINSGIINHAFYLLSVGLND------------AI-GTEAAAKIFYRAL 540 
WP_110168929  464 ------QPKHM----Rdfv----vtTRDHGGVHTNSGIHNFAAFKVMTAKDSs-----GdF----VfTPKECAAIFYLTL 520 
WP_080040295  450 ------AARDYlga---------tvSIDNGGVHLNSTIFSGALWDVREQL-----------------GGKKADKLAYKAL 497 
WP_111372300  495 d--pgyQPKNM----SqyvylrdtpSEDNGGVHINSGIPNHAFYLFATAN--------------GM-NKDKAEKVYYHTL 553 
NP_714341     593 H-YLSPTSGYVATRSAAILAAKNLY-----GKFSSEVKSTIDAWDAVGVP---AETTSRGGDGMRKVGNYITSVKLSGME 663 
WP_063610305  497 SeYMTPLDDFTDGRRAVLAAAARM------RLGAKDLLTIARAFDAHGIK---AGWERRIPTDHDVLLRGITDLYAQPDA 567 
WP_013766274  593 SnYLTRSSRFVDARLAVVRAAREKG-----GESv--AKAAESAFETVGIR---VSAPTAPPPNLGINPGTQFVLGVKSDK 662 
WP_015100225  464 TeYLTPLDTFVDGRTAVLGAAAAL------KLTARQQATIARAFDDHGI----VPGWEQRLGTDSTTLVPGVTSVSPFPS 533 
WP_082083047  581 VtKLNPNSDFIALREACILSAEEIH-----GVGTTQVTKVRAAFDAVEIF---DATIVGMPSDLTPASGQDSYLFSYLAV 652 
WP_013995234  577 StYLTASSQFIDLRIAVVQSALDLH-----GENSAEVAAIETAFDTVGIT---AGTSTDTDNDIPLAEGDEFILSLDIRD 648 
WP_062151957  541 TqYLTRNSQFTDARLAAINAAHDLY-----GQNAIEAQKVAEAFDAVGLL---ADNPTTPSPTSFNPVSEAPDALLSACL 612 
WP_110168929  521 TqRLSRTSQFIDSRVGAVASAQSLFrndpaATRAKKIQTVEQGFSAAGIV------------------------------ 570 
WP_080040295  498 TeYMTPLDDFVDGRRAVESAARAL------GWSARDRQTVARAFDQHGIK---AGWERLLRTDSRTLIDGITDIQARPDV 568 
WP_111372300  554 SnYITRTSKFVDLRLAVIQGTKDLY-----GEG-LESAAAASAFDQVGIAapgSGQQVPTTEEEIIEVNPGEQFLIVYEP 627 
NP_714341     664 NNSGNDCGYKDNTYLHPWVLKGGTYQLVLSSEGSQLPLKSHKWSVWIDLNRNGIFDSSEIILQTSNQLWGEGTLQRSIVI 743 
WP_063610305  568 AGDRYVITNSSADLSAPPAVYTGRVRGGRAELLSAPGEQYNFAPATDGRTGAWATYVDTGTAWKIQVWSRPLDRSRPPAL 647 
WP_013766274  663 SGIGIFDVNKNTILELNISNGVLKKPSISDDGSFVIYINGRKQLKYLELDWAQASFDTGTLSNNRIWENVALSKDGLRLA 742 
WP_015100225  534 AANGRYVVLLSDPRGEQAAEVFAGRTDRATPPVRLSAKDGTSNAQTNTDGTTAVWSNRSRAGSRILARTLDGGPLRTVVD 613 
WP_082083047  653 DGNYYLGRREGALGDGSGVVGIAGTPMNPDTRPSVSGDGSLAVFVSSTFDLVVAPTNGSGATSLGYPGQVYATTLSADSK 732 
WP_013995234  649 TDPNTIYASDTEATIYYPLTTTGVHRKPSVSDDGSFAIFVTEENKVNAISLDVNAPEESVISEDPVWAAVSLSKDGTKLA 728 
WP_062151957  613 TSTGDTKLCRYDTNLGDTEPVILSTSSIKPLKRVSIQGDGSMAVFINANDDLCFIEINNGQEACAGFDDVHSVTMSPDGN 692 
WP_110168929      --------------------------------------------------------------------------------     
WP_080040295  569 AGDRYVVSDASPAGEPPTRILAGRLRGGTPVTLEDNDRYNYLPVTDGRQVAWASYNAAFDSFQVHARPIDGSAPARLVHQ 648 
WP_111372300  628 EGKSIYRGAAGGENYDVVAEGLGCQRKPSISDDGTAMYFVAADGNIYYVDLTASAATAQPLSSNGAWSNVAISKNGTLLA 707 
NP_714341     744 PT 745 
WP_063610305  648 VH 649 
WP_013766274  743 AL 744 
WP_015100225  614 GG 615 
WP_082083047  733 HM 734 
WP_013995234  729 SV 730 
WP_062151957  693 RY 694 
WP_110168929      --     
WP_080040295  649 SP 650 
WP_111372300  708 AL 709 
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